Evaluation of Resveratrol and Piceatannol Anticonvulsant Potential in Adult Zebrafish (Danio rerio)

Pedroso, Jefferson; Schneider, Sabrina Ester; Lima‐Rezende, Cássia Alves; Aguiar, Gean Pablo S.; Müller, Liz Girardi; Oliveira, J. Vladimir; Piato, Ângelo; Siebel, Anna Maria

doi:10.1007/s11064-022-03656-3

Cited by 5 publications

(1 citation statement)

References 57 publications

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“…Thus, no anticonvulsant and neuroprotective potential of resveratrol and piceatannol was found in adult zebrafish at the mentioned doses. However, it was suggested that further studies could be done to determine the possible benefits of piceatannol in the treatment of epilepsy (Pedroso et al, 2022).…”

Section: Stilbenes In Neuropsychiatric and Neurological Disordersmentioning

confidence: 99%

Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: A comprehensive review of preclinical and clinical evidence

Socała,

Żmudzka,

Lustyk

et al. 2024

Phytotherapy Research

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Neuropsychiatric disorders are anticipated to be a leading health concern in the near future, emphasizing an outstanding need for the development of new effective therapeutics to treat them. Stilbenes, with resveratrol attracting the most attention, are an example of multi‐target compounds with promising therapeutic potential for a broad array of neuropsychiatric and neurological conditions. This review is a comprehensive summary of the current state of research on stilbenes in several neuropsychiatric and neurological disorders such as depression, anxiety, schizophrenia, autism spectrum disorders, epilepsy, traumatic brain injury, and neurodegenerative disorders. We describe and discuss the results of both in vitro and in vivo studies. The majority of studies concentrate on resveratrol, with limited findings exploring other stilbenes such as pterostilbene, piceatannol, polydatin, tetrahydroxystilbene glucoside, or synthetic resveratrol derivatives. Overall, although extensive preclinical studies show the potential benefits of stilbenes in various central nervous system disorders, clinical evidence on their therapeutic efficacy is largely missing.

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Section: Stilbenes In Neuropsychiatric and Neurological Disordersmentioning

confidence: 99%