Exposure to Severe Wartime Conditions in Early Life Is Associated With an Increased Risk of Irritable Bowel Syndrome: A Population-Based Cohort Study

Klooker, Tamira K.; Braak, Breg; Painter, Rebecca C.; Rooij, Susanne R. de; Elburg, Ruurd M. van; Wijngaard, René M. van den; Roseboom, Tessa J.; Boeckxstaens, Guy E.

doi:10.1038/ajg.2009.282

Cited by 78 publications

(52 citation statements)

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“…Conversely, psychological factors themselves influence physiological factors, such as the motor, sensory, secretory and immune functions of the gastrointestinal tract (top-down model) (38). Previous studies have shown that early life stressors, such as sexual abuse and maternal separation, are related to the development of IBS (39)(40)(41). Understanding the psychological problems of IBS patients might contribute to the development of effective treatments.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Predictive Factors of Irritable Bowel Syndrome in a Community-dwelling Population in Japan

et al. 2015

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Objective Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized by chronic, relapsing abdominal pain or discomfort and is associated with disturbed defecation. The pathogenesis of IBS is multifactorial. The aim of this study was to investigate the prevalence of IBS using the Rome III criteria and to assess the effects of mental and lifestyle factors on IBS in a community-dwelling population in Japan. Methods The diagnosis of irritable bowel syndrome was based on the Japanese version of the Rome III Questionnaire. The questionnaire was administered to 993 volunteers who participated in the Iwaki Health Promotion Project 2013. Diet was assessed with a validated brief-type self-administered diet history questionnaire. Dietary patterns based on 52 predefined food groups [energy-adjusted food (g/d)] were extracted using a principal component analysis. The Center for Epidemiologic Studies Depression Scale with a cut-off point of 16 was used to assess the prevalence of depression. Results A total of 61 subjects (6.1%) were classified as having IBS. Three dietary patterns were identified: "Healthy", "Western" and "Alcohol and accompanying" dietary patterns. After adjusting for potential confounders, the "Alcohol and accompanying" dietary pattern and depression were related to the risk of IBS. Conclusion We found that an "Alcohol and accompanying" dietary pattern and depression were related to the risk of IBS in a Japanese community population. However, we could not rule out the possibility of some selection bias. Further studies with longitudinal observations are therefore warranted.

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Section: Discussionmentioning

confidence: 99%

Prevalence and Predictive Factors of Irritable Bowel Syndrome in a Community-dwelling Population in Japan

et al. 2015

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“…2,3 For example, in 2009, one retrospective cohort study evaluating the epidemiology of IBS in the World War II period showed that the factor of early life exposure to severe wartime conditions was related with the increase of IBS prevalence. 4 In 2012, Bradford et al 2 found that IBS patients had more EALs such as common trauma, corporal punishment, emotional abuse or sexual assault than healthy subjects. Animal research has played a vital role in advances in the pathophysiology of IBS.…”

Section: Introductionmentioning

confidence: 99%

Maternal Separation Induced Visceral Hypersensitivity from Childhood to Adulthood

Zhang

Sun

et al. 2017

J Neurogastroenterol Motil

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Background/AimsEarly adverse life events (EALs) are relevant to irritable bowel syndrome in adulthood. Maternal separation (MS), as one of the EALs, has proved to induce visceral hypersensitivity in adult rats. However, the effect of MS on visceral hypersensitvity from the post-weaning period to adulthood remains unknown. MethodsOne hundred and ten neonatal Sprague-Dawley rats were randomly divided into 2 groups: rats in the MS group were exposed to 3 hours daily MS on postnatal day (PND) 2-14; the normal control (NC) group remained undisturbed. Visceral sensitivity was determined by measuring the visceromotor response to colorectal distention on PND21, 35, and 56. Anxiety-like behaviors were measured by the open field test. ResultsCompared with NC rats, MS rats showed significant visceral hypersensitivity from the post-weaning period to adult. The proportion of visceral hypersensitive rats decreased with age from 87.5% to 70.0% in the female MS group and from 90.0% to 66.7% in the male MS group. The relative VMR ratio of MS and NC on PND21 was higher than PND35 and PND56. MS rats showed decreased ability of movement and exploration to the novel environment in the post-weaning period, obesity in the prepubertal period, and more anxietylike behaviors in adulthood. ConclusionsMS can significantly affect visceral sensitivity and behaviors of rats in different age stages, especially in the post-weaning period. Visceral hypersensitivity of MS rats is more pronounced in the post-weaning period and slightly restored in adults. Thus, visceral hypersensitivity in the post-weaning period might play a more meaningful pathophysiologic role in the formation of adult irritable bowel syndrome.

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“…Findings include a weak association of congenital heart defects and ambient temperatures (Agay-Shay et al 2013) and lower levels of cord blood ferritin in mothers exposed to war compared to non-exposed mothers (Armony-Sivan et al 2013). No association was found between exposure to famine and prevalence of irritable bowel syndrome (IBS) (Klooker et al 2009), or between breast cancer and exposure to famine (Painter et al 2006a). Louphaä et al (2000) found a weak association between mid-gestation exposure to famine and a higher prevalence of obstructive airways disease (OR 1.7, 95 % CI 1.1, 2.6), and a study on asthma and exposure to an ice storm found a weak associated in females between high levels of subjective maternal stress and diagnosed asthma (OR 1.09, 95 % CI 1.00, 1.19) (Turcotte-Tremblay and Lim 2014).…”

Section: Resultsmentioning

confidence: 98%

A systematic review of the health effects of prenatal exposure to disaster

Saulnier

Brolin

2015

Int J Public Health

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Due to the lack of variety in type of events studied, as well as large methodological variation, it is difficult to draw firm conclusions from existing literature. However, our systematic review highlights the potential of evaluating secondary data, both to accentuate research gaps in the field and to increase the understanding of what effects various types of disasters potentially have on the unborn child.

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Exposure to Severe Wartime Conditions in Early Life Is Associated With an Increased Risk of Irritable Bowel Syndrome: A Population-Based Cohort Study

Cited by 78 publications

References 31 publications

Prevalence and Predictive Factors of Irritable Bowel Syndrome in a Community-dwelling Population in Japan

Prevalence and Predictive Factors of Irritable Bowel Syndrome in a Community-dwelling Population in Japan

Maternal Separation Induced Visceral Hypersensitivity from Childhood to Adulthood

A systematic review of the health effects of prenatal exposure to disaster

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