Maternal Separation Induced Visceral Hypersensitivity from Childhood to Adulthood

Yi, Lingling; Zhang, Haiqin; Sun, Huihui; Zhou, Lü; Chen, Ying; Xuan, Liqian; Jiang, Yilin; Xu, Shuchang

doi:10.5056/jnm16089

Cited by 28 publications

(27 citation statements)

References 32 publications

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“…In humans, stress occurring during this critical time point has been linked to the development of both somatic and psychiatric phenotypes including depression, anxiety disorders and irritable bowel syndrome (Folks, 2004;Plotsky et al, 2005;Seckl, 2007). Maternal separation (MS) in rodents is a well-established animal model of early-life stress and results in a variety of long-term behavioural and physiological effects in adult offspring (O'Mahony, Hyland, Dinan, & Cryan, 2011;Yi et al, 2017). Included in these alterations are stress hyper-responsivity, increased depressive-like behaviour, visceral hypersensitivity and reduced diversity of intestinal microbiota, thus demonstrating the face validity of this model (Bailey & Coe, 1999;O'Mahony et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

The enduring effects of early‐life stress on the microbiota–gut–brain axis are buffered by dietary supplementation with milk fat globule membrane and a prebiotic blend

O’Mahony

Neufeld

Waworuntu

et al. 2019

Eur J of Neuroscience

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Nutritional interventions targeting the microbiota–gut–brain axis are proposed to modulate stress‐induced dysfunction of physiological processes and brain development. Maternal separation (MS) in rats induces long‐term alterations to behaviour, pain responses, gut microbiome and brain neurochemistry. In this study, the effects of dietary interventions (milk fat globule membrane [MFGM] and a polydextrose/galacto‐oligosaccharide prebiotic blend) were evaluated. Diets were provided from postnatal day 21 to both non‐separated and MS offspring. Spatial memory, visceral sensitivity and stress reactivity were assessed in adulthood. Gene transcripts associated with cognition and stress and the caecal microbiota composition were analysed. MS‐induced visceral hypersensitivity was ameliorated by MFGM and to greater extent with the combination of MFGM and prebiotic blend. Furthermore, spatial learning and memory were improved by prebiotics and MFGM alone and with the combination. The prebiotic blend and the combination of the prebiotics and MFGM appeared to facilitate return to baseline with regard to HPA axis response to the restraint stress, which can be beneficial in times where coping mechanisms to stressful events are required. Interestingly, the combination of MFGM and prebiotic reduced the long‐term impact of MS on a marker of myelination in the prefrontal cortex. MS affected the microbiota at family level only, while MFGM, the prebiotic blend and the combination influenced abundance at family and genus level as well as influencing beta‐diversity levels. In conclusion, intervention with MFGM and prebiotic blend significantly impacted the composition of the microbiota as well as ameliorating some of the long‐term effects of early‐life stress.

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Section: Introductionmentioning

confidence: 99%

The enduring effects of early‐life stress on the microbiota–gut–brain axis are buffered by dietary supplementation with milk fat globule membrane and a prebiotic blend

O’Mahony

Neufeld

Waworuntu

et al. 2019

Eur J of Neuroscience

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“…In these models, rats exposed to prenatal or neonatal stress exhibit visceral hypersensitivity in adulthood . Animal models of maternal separation, limited nesting, and odor‐associated learning demonstrate visceral hypersensitivity in adulthood, long after the initial stressor in neonatal life has been removed . Compared to undisturbed littermates, animals that received neonatal stress had long‐lasting changes in gene expression, underlying and inducing visceral hypersensitivity.…”

Section: Epigenetic Mechanisms In Visceral Painmentioning

confidence: 99%

“…105 Animal models of maternal separation, limited nesting, and odor-associated learning demonstrate visceral hypersensitivity in adulthood, long after the initial stressor in neonatal life has been removed. [106][107][108] Compared to undisturbed littermates, animals that received neonatal stress had long-lasting changes in gene expression, underlying and inducing visceral hypersensitivity. The longevity of these changes is best explained through stress-induced detrimental changes in epigenetic regulation.…”

Section: Evidence Pointing Toward Epigenetic Regulationmentioning

confidence: 99%

Targeting epigenetic mechanisms for chronic visceral pain: A valid approach for the development of novel therapeutics

Louwies

Ligon

Johnson

et al. 2018

Neurogastroenterology Motil

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Background Chronic visceral pain is persistent pain emanating from thoracic, pelvic, or abdominal origin that is poorly localized with regard to the specific organ affected. The prevalence can range up to 25% in the adult population as chronic visceral pain is a common feature of many visceral disorders, which may or may not be accompanied by distinct structural or histological abnormalities within the visceral organs. Mounting evidence suggests that changes in epigenetic mechanisms are involved in the top‐down or bottom‐up sensitization of pain pathways and the development of chronic pain. Epigenetic changes can lead to long‐term alterations in gene expression profiles of neurons and consequently alter functionality of peripheral neurons, dorsal root ganglia, spinal cord, and brain neurons. However, epigenetic modifications are dynamic, and thus, detrimental changes may be reversible. Hence, external factors/therapeutic interventions may be capable of modulating the epigenome and restore normal gene expression for extended periods of time. Purpose The goal of this review is to highlight the latest discoveries made toward understanding the epigenetic mechanisms that are involved in the development or maintenance of chronic visceral pain. Furthermore, this review will provide evidence supporting that targeting these epigenetic mechanisms may represent a novel approach to treat chronic visceral pain.

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“…The chronic stressful life events experienced in adulthood are also found to be one of risk factors of IBS [11][12][13]. Many previous pre-clinical rodent studies have also demonstrated that chronic stress in adulthood might induce visceral hypersensitivity, which was the key clincial features of IBS [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

A case-control study of childhood trauma and recent adverse life events in the development of irritable bowel syndrome

Dong

Wang

Xuan

et al. 2020

Preprint

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Background: Childhood trauma has been found to be associated with irritable bowel syndrome (IBS) in adulthood, whereas whether recent adverse life events affect the effect of childhood trauma on IBS is still poorly understood.Methods: 56 IBS and 50 healthy controls were enrolled. The Childhood Trauma Questionnaire (CTQ), Life Event Scale, IBS – Quality Of Life (IBS-QOL), IBS – Severity Scoring System (IBS-SSS) and MOS 36-item Short-Form Health Survey (SF-36) were completed in IBS patients and healthy controls. The logistic regression model, correlation analysis and student t-test were used to investigate the relationship among childhood trauma, recent adverse life events and IBS.Results: Gender, emotional abuse and recent adverse life events were independent predictors for IBS in adulthood. The overall CTQ was highly correlated with IBS-QOL and mental component summary in SF-36, but was moderately and weakly correlated with IBS-SSS and physical component summary in SF-36 respectively. The similar correlation of overall CTQ with IBS-QOL, physical component summary and mental component summary was found in both subgroups stratified by recent adverse life events. However, the correlation between overall CTQ and IBS-SSS was blunted in IBS patients with recent adverse life events. There was no significant difference on severity of symptoms and life quality between IBS patients who had experience of childhood trauma with or without recent adverse life events.Conclusions Female gender, emotional abuse and recent adverse life events were associated with a higher prevelance of IBS in adulthood. Childhood trauma might enhence severity of symptoms and worsen quality of life in IBS patients. However, recent adverse life events might dilute this correlation of childhood trauma with severity of symptoms, but not stengthen the effect of childhood trauma on symptoms.

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Maternal Separation Induced Visceral Hypersensitivity from Childhood to Adulthood

Cited by 28 publications

References 32 publications

The enduring effects of early‐life stress on the microbiota–gut–brain axis are buffered by dietary supplementation with milk fat globule membrane and a prebiotic blend

The enduring effects of early‐life stress on the microbiota–gut–brain axis are buffered by dietary supplementation with milk fat globule membrane and a prebiotic blend

Targeting epigenetic mechanisms for chronic visceral pain: A valid approach for the development of novel therapeutics

A case-control study of childhood trauma and recent adverse life events in the development of irritable bowel syndrome

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