Exposure to polycyclic aromatic hydrocarbons in women living in the Chinese cities of BaoDing and Dalian revealed by hair analysis

Palazzi, Paul; Mezzache, Sakina; Bourokba, Nasrine; Hardy, Emilie; Schritz, Anna; Bastien, Philippe; Emond, Claude; Li, Jing; Sœur, Jérémie; Appenzeller, Brice

doi:10.1016/j.envint.2018.10.056

Cited by 53 publications

(48 citation statements)

References 59 publications

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“…In Baoding, the median concentration was 1.5 to 2.8 times higher for parent PAHs and 1.1 to 2.3 times higher for metabolites than in Dalian. Among the parent PAHs quantified, higher levels were observed for phenanthrene, fluoranthene, pyrene, fluorene, acenaphthylene, and anthracene, while for metabolites, 9-OH fluorene, 2-OH-naphtalene, and 1-OH-anthracene were higher [11].…”

Section: Skin Site and City As Main Drivers Of Microbiome Variation Imentioning

confidence: 94%

“…Furthermore, biomonitoring of PAHs showed quantitative differences in the exposure levels between the two populations [11]. Specifically, of the parent PAHs and metabolites detected, 14 out of 15 and 14 out of 56 presented significantly higher concentrations in the hair samples of subjects from Baoding compared to Dalian, respectively.…”

Section: Skin Site and City As Main Drivers Of Microbiome Variation Imentioning

confidence: 95%

“…Participants living in the two cities were evaluated for their facial signs and exposure to PAHs in 12-cm hair samples (reflecting the extent of exposure during a 1year period) [10,11]. An increased severity was observed in almost all facial signs, including wrinkles and pigmentation disorders, in individuals living in Baoding [10].…”

Section: Skin Site and City As Main Drivers Of Microbiome Variation Imentioning

confidence: 99%

“…An increased severity was observed in almost all facial signs, including wrinkles and pigmentation disorders, in individuals living in Baoding [10]. [11]. b Annual mean concentrations of PM 10 and PM 2.5 in outdoor air for cities of selected countries for the years 2013 to 2016.…”

Section: Skin Site and City As Main Drivers Of Microbiome Variation Imentioning

confidence: 99%

“…Clinical studies have correlated daily exposure to particulate matter (PM) with increased skin pigmentation spots and wrinkles [8][9][10]. Among the constituents of harmful atmospheric pollution, polycyclic aromatic hydrocarbons (PAHs), a class of organic pollutants in ambient air commonly associated with PM, may enter the human body and bloodstream via inhalation, ingestion, and dermal absorption [11][12][13]. While chronic dermal exposure to PAHs may be associated with premature skin aging, pigmentary disorder, acne, and skin cancer [10,14,15], the exact mechanisms by which PAH pollution harms the skin remain poorly understood and are likely to be complex and multifaceted.…”

Section: Introductionmentioning

confidence: 99%

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Changes of the human skin microbiota upon chronic exposure to polycyclic aromatic hydrocarbon pollutants

Leung¹,

Tong²,

Bastien³

et al. 2020

Microbiome

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Background: Polycyclic aromatic hydrocarbons (PAHs) are of environmental and public health concerns and contribute to adverse skin attributes such as premature skin aging and pigmentary disorder. However, little information is available on the potential roles of chronic urban PAH pollutant exposure on the cutaneous microbiota. Given the roles of the skin microbiota have on healthy and undesirable skin phenotypes and the relationships between PAHs and skin properties, we hypothesize that exposure of PAHs may be associated with changes in the cutaneous microbiota. In this study, the skin microbiota of over two hundred Chinese individuals from two cities in China with varying exposure levels of PAHs were characterized by bacterial and fungal amplicon and shotgun metagenomics sequencing. Results: Skin site and city were strong parameters in changing microbial communities and their assembly processes. Reductions of bacterial-fungal microbial network structural integrity and stability were associated with skin conditions (acne and dandruff). Multivariate analysis revealed associations between abundances of Propionibacterium and Malassezia with host properties and pollutant exposure levels. Shannon diversity increase was correlated to exposure levels of PAHs in a dose-dependent manner. Shotgun metagenomics analysis of samples (n = 32) from individuals of the lowest and highest exposure levels of PAHs further highlighted associations between the PAHs quantified and decrease in abundances of skin commensals and increase in oral bacteria. Functional analysis identified associations between levels of PAHs and abundance of microbial genes of metabolic and other pathways with potential importance in host-microbe interactions as well as degradation of aromatic compounds. Conclusions: The results in this study demonstrated the changes in composition and functional capacities of the cutaneous microbiota associated with chronic exposure levels of PAHs. Findings from this study will aid the development of strategies to harness the microbiota in protecting the skin against pollutants.

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Section: Skin Site and City As Main Drivers Of Microbiome Variation Imentioning

confidence: 94%

Section: Skin Site and City As Main Drivers Of Microbiome Variation Imentioning

confidence: 95%

Section: Skin Site and City As Main Drivers Of Microbiome Variation Imentioning

confidence: 99%

Section: Skin Site and City As Main Drivers Of Microbiome Variation Imentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Changes of the human skin microbiota upon chronic exposure to polycyclic aromatic hydrocarbon pollutants

Leung¹,

Tong²,

Bastien³

et al. 2020

Microbiome

Self Cite

View full text Add to dashboard Cite

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In Vitro Methods to Simulate Pollution and Photo-Pollution Exposure in Human Skin Epidermis

Misra

Marrot

2020

Imaging and Tracking Stem Cells

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Blood pharmacokinetic of 17 common pesticides in mixture following a single oral exposure in rats: implications for human biomonitoring and exposure assessment

et al. 2019

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Exposure to polycyclic aromatic hydrocarbons in women living in the Chinese cities of BaoDing and Dalian revealed by hair analysis

Cited by 53 publications

References 59 publications

Changes of the human skin microbiota upon chronic exposure to polycyclic aromatic hydrocarbon pollutants

Changes of the human skin microbiota upon chronic exposure to polycyclic aromatic hydrocarbon pollutants

In Vitro Methods to Simulate Pollution and Photo-Pollution Exposure in Human Skin Epidermis

Blood pharmacokinetic of 17 common pesticides in mixture following a single oral exposure in rats: implications for human biomonitoring and exposure assessment

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