Blood pharmacokinetic of 17 common pesticides in mixture following a single oral exposure in rats: implications for human biomonitoring and exposure assessment

Chata, Caroline; Palazzi, Paul; Grova, Nathalie; Haan, Serge; Emond, Claude; Vaillant, Michel; Appenzeller, Brice

doi:10.1007/s00204-019-02546-y

Cited by 9 publications

(7 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, the presence of DEHP, DINCH, and bisphenol A in cages, enrichment material, and food might lead to background exposure comparable to or even higher than the dose administered to the animals through gavage. Although no analysis was conducted on rats’ food and surroundings in the present work, previous studies already reported such background exposure leading to detectable levels of concentration of biomarkers in biological samples collected from control animals supposedly unexposed . Background contamination, which seems almost unavoidable for some chemicals, could therefore exceed the dose administered to the animals (at least for some groups) and therefore hide the relationship between exposure and resulting concentration in hair.…”

Section: Discussionmentioning

confidence: 74%

“…Although no analysis was conducted on rats' food and surroundings in the present work, previous studies already reported such background exposure leading to detectable levels of concentration of biomarkers in biological samples collected from control animals supposedly unexposed. 24 Background contamination, which seems almost unavoidable for some chemicals, could therefore exceed the dose administered to the animals (at least for some groups) and therefore hide the relationship between exposure and resulting concentration in hair. The presence of BPA, DEHP, and DINCH metabolites in the hair of the control animals, as well as in the urine samples collected before gavage, strongly supports this hypothesis (Supplemental Figure 2).…”

Section: Discussionmentioning

confidence: 99%

“…These PK parameters consisted of 5 among the most used in the literature: − , maximum urinary concentration ( C max ) in μg/L, time needed to reach C max ( T max ) in hours, area under the concentration–time curve from zero hour to infinity (AUC 0–∞ , (μg h)/L) with interpolation of concentrations for the beginning and end of the interval, and mean residence time (MRT) and half-life ( t 1/2 ) in hours. The elimination half-life was estimated from the final points in the concentration–time curve using semilog regression (log(conc) ≈ time) with automated selection of the points for calculation by the PKNCA package.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Incorporation of Fast-Elimination Chemicals in Hair Is Governed by Pharmacokinetics–Implications for Exposure Assessment

Faÿs

Palazzi

Zeman

et al. 2023

Environ. Sci. Technol.

Self Cite

View full text Add to dashboard Cite

Mechanisms governing chemicals’ incorporation in hair are incompletely understood, and gaps remain to link the concentration of chemicals in hair to level of exposure and internal dose present in the body. This study assesses the relevance of hair analysis for the biomonitoring of exposure to fast-elimination compounds and investigates the role of pharmacokinetics (PK) in their incorporation in hair. Rats were administered with pesticides, bisphenols, phthalates, and DINCH over 2 months. Hairs were analyzed for 28 chemicals/metabolites to investigate correlations between their concentration in hair and the dose administered to the animals. Urine collected over 24 h after gavage was used to determine chemicals’ PK and to investigate their influence on incorporation into hair by means of linear mixed models (LMMs). Eighteen chemicals presented a significant correlation between concentration in hair and level of exposure. In models combining all chemicals, agreement between concentration in hair predicted by LMM and experimental values was moderate (R 2 = 0.19) but significantly increased when PK were included in the models (R 2 = 0.37), and even more when chemical families were considered separately (e.g., R 2 = 0.98 for pesticides). This study shows that pharmacokinetics mediate incorporation of chemicals in hair and suggests the relevance of hair for assessing exposure to fast-elimination chemicals.

show abstract

Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Incorporation of Fast-Elimination Chemicals in Hair Is Governed by Pharmacokinetics–Implications for Exposure Assessment

Faÿs

Palazzi

Zeman

et al. 2023

Environ. Sci. Technol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The conversion of FIP to SULF occurred quickly at the three doses administered. High conversion of FIP to SULF through hepatic metabolism has been reported after oral administration in rats (Chata et al, 2019; Roques et al, 2012). Biotransformation of FIP was not dose‐dependent, as no significant difference was observed for the values of C max and AUC 0− t of SULF between doses.…”

Section: Discussionmentioning

confidence: 96%

Oral pharmacokinetic profile of fipronil and efficacy against flea and tick in dogs

Santos

Scott

Campos

et al. 2021

Vet Pharm & Therapeutics

View full text Add to dashboard Cite

Fipronil (FIP) is an ectoparasiticide of the phenylpyrazole class, used in veterinary medicine in topical form. Supported by evidence of uncontrolled human exposure to FIP and environmental damage caused by commercially available formulations, its use by oral administration has become promising. The effectiveness of FIP against the flea Ctenocephalides felis felis and the tick Rhipicephalus sanguineus and its pharmacokinetics and main active metabolite, fipronil sulfone (SULF) were evaluated after single oral administration of tablets in three different doses (2, 4, and 6 mg/kg) in dogs. Through the plasma concentration curves, it was possible to observe that the FIP showed rapid absorption and metabolization and slow elimination. The values of Cmax (β = 0.7653) and AUC0‐t (β = 0.3209) did not increase proportionally with increasing dose. At 48 h after treatment, doses of 4 mg/kg (AUC0−t = 442.39 ± 137.35 µg/ml*h) and 6 mg/kg (AUC0−t = 421.32 ± 102.84 µg/ml*h) provided 100% and 99% efficacy against fleas, and 95% and 98% against ticks, respectively. The estimated EC90 of FIP +SULF was 1.30 µg/ml against C. felis felis and 2.16 µg/ml against R. sanguineus. The correlation between the FIP pharmacokinetic and efficacy data demonstrated its potential for oral administration in the form of tablets for the control of ectoparasites in dogs, as a safer alternative for animals, humans, and the environment, aligned with the One Health concept.

show abstract

“…On gestational day 16, all mice received a final dose 90 min before euthanasia. Previous studies have demonstrated maximum blood concentrations of pyrethroids in rats approximately 1–2 h after oral administration ( Singh et al, 2016 ; Chata et al, 2019 ). Pregnant dams were euthanized by ketamine/xylazine anesthesia followed by rapid decapitation.…”

Section: Methodsmentioning

confidence: 99%

Maternal and fetal tissue distribution of α-cypermethrin and permethrin in pregnant CD-1 mice

Elser

Simonsen

Lehmler

et al. 2022

Environmental Advances

View full text Add to dashboard Cite

Blood pharmacokinetic of 17 common pesticides in mixture following a single oral exposure in rats: implications for human biomonitoring and exposure assessment

Cited by 9 publications

References 41 publications

Incorporation of Fast-Elimination Chemicals in Hair Is Governed by Pharmacokinetics–Implications for Exposure Assessment

Incorporation of Fast-Elimination Chemicals in Hair Is Governed by Pharmacokinetics–Implications for Exposure Assessment

Oral pharmacokinetic profile of fipronil and efficacy against flea and tick in dogs

Maternal and fetal tissue distribution of α-cypermethrin and permethrin in pregnant CD-1 mice

Contact Info

Product

Resources

About