Exposure to pesticides and the prevalence of diabetes in a rural population in Korea

Park, Sung Jin; Kim, Sung Kyung; Kim, Jae Yeop; Lee, Kyungsuk; Choi, Jung Ran; Chang, Sei-Jin; Chung, Choon Hee; Park, Kyu Sang; Oh, Sung Soo; Koh, Sang Baek

doi:10.1016/j.neuro.2018.10.007

Cited by 42 publications

(20 citation statements)

References 36 publications

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“…Agricultural productivity is essential to sustaining the nutritional and health status of billions of people [3], and small farmers are critical to the global food supply [4]. However, agriculture is a dangerous profession [5] and with priority of attention [6], due to its occupational health risks and the presence of non-communicable chronic diseases and their risk factors [7][8][9][10][11].…”

mentioning

confidence: 99%

“…Despite the finding of an increase in the morbidity and mortality profile of this population [7][8][9][10][11], representative research on the food consumption of farmers and the rural population is still scarce [18], especially studies developed with the purpose of studying the dietary patterns of these populations and their associated factors [4][5][6][19][20][21][22][23][24][25][26][27][28][29].…”

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confidence: 99%

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Dietary patterns of Brazilian farmers and their relation with sociodemographic, labor, and lifestyle conditions

Cattafesta

Petarli

Luz

et al. 2020

Preprint

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Background: The eating habits have changed in the last few decades, but few studies prioritize the food consumption of farmers and the rural population. In this scenario, the objective of this paper was to define the dietary patterns of farmers in a Brazilian municipality and explore the sociodemographic, occupational and lifestyle factors to the high adherence these dietary patterns. Methods: This is a cross-sectional epidemiological study of 740 farmers (51.5%, n=381 males; 48.5%, n=359 females) from a municipality in Southeastern Brazil. Food intake data were obtained by applying multipass 24-hour recall and dietary intake was presented in dietary patterns determined by Principal Component Analysis with varimax orthogonal rotation.Results: Three dietary patterns were identified. The first pattern, “local traditional”, was associated with sociodemographic and labor variables, being considered typical of the region's farmer as white race/color (p=0.003), not extra-physical activity (p=0.014) and cultivating 5 or more crops (p=0.005). The permanence of a “traditional Brazilian” pattern and the occurrence of an “industrialized” pattern were also observed. Farmers working in non-conventional agriculture were 54% less adhere to “traditional Brazilian” pattern (OR 0.46, 95% CI 0.25–0.86, p=0.014). Individuals aged 50 and over years were 82% less likely (OR 0.18, 95% CI 0.10–0.30) to adhere to “industrialized” pattern. Still, individuals of lower socioeconomic class were 52% less likely to adhere to this pattern (OR 0.48, 95% CI 0.24–0.96). Farmers who spent R$ 200 or more per capita to buy food were more than twice as likely to adhere to this food pattern (95% CI 1.32–3.73), and who had the habit of frequently eating out were 1.62 as likely adhere to “industrialized” pattern (95% CI 1.11–2.36). Conclusion: The findings indicate changes in dietary patterns in rural areas of the country, maintaining a traditional Brazilian pattern, as well as a local and an industrialized pattern. This last pattern demonstrates that the contemporary rural population also opts for a diet with ultra-processed products, being associated with the characteristic habits of a more urbanized rural region.

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confidence: 99%

mentioning

confidence: 99%

Dietary patterns of Brazilian farmers and their relation with sociodemographic, labor, and lifestyle conditions

Cattafesta

Petarli

Luz

et al. 2020

Preprint

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“…Unfortunately, they had difficulty in describing them accurately [32] and, thus, most of them failed to answer the items correctly. However, studies have been performed on health effects of pesticide exposure using this method to evaluate exposure without the information on the type of pesticides [13,14,33,34]. Finally, only 501 of 2568 (approximately 20%) individuals who completed the pesticide exposure assessment agreed to undergo CIMT measurements for inclusion in this study.…”

Section: Plos Onementioning

confidence: 99%

“…As an alternative option, the assessment of pesticide exposure using questionnaires of patient recall of exposure is the only available approach to estimate cumulative exposure in lifetime [12]. This alternative measurement of pesticide exposure has been widely utilized to evaluate the effects of pesticides on several health outcomes [13,14].…”

Section: Introductionmentioning

confidence: 99%

Increased risk of atherosclerosis associated with pesticide exposure in rural areas in Korea

et al. 2020

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Atherosclerosis is a progressive inflammation in systemic vessels, and pesticide exposure has been emerging as its risk factor. This cross-sectional study investigated the association between pesticide exposure and the risk of atherosclerosis in a rural population in Korea using carotid intima-media thickness (CIMT). This study used dataset from the baseline survey of the Korea Farmers Cohort Study between November 2005 and January 2008, and the final analysis included 477 participants. Well-structured questionnaires were used to estimate pesticide exposure. CIMT � 0.9 mm was established for carotid atherosclerosis. Multiple logistic regression analyses were undertaken to evaluate the association between pesticide exposure and atherosclerosis, adjusting demographic and health-related confounders. Even after adjustments, the increased risk of atherosclerosis was significantly associated with pesticide exposure, such as a lifetime history of farming (odds ratio [OR] 3.25 95% confidence interval [CI] 1.51-6.98), a history of using pesticide (OR 3.42 95% CI 1.63-7.16), using pesticide 10 times or more annually (OR 2.55 95% CI 1.21-5.39), and higher cumulative exposure index level (OR 3.63 95% CI 1.65-7.97). Further prospective studies are required to elucidate effects of pesticide exposure on the risk of atherosclerosis.

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“…A similar positive relationship between BMI and the level of 3‐phenoxybenzoic acid, a major pyrethroid metabolite, has also been found in adults according to the Korean National Environmental Health Survey (Yoo et al, ). In addition, pyrethroid exposure and diabetes in the United States are strongly positively correlated according to the National Health and Nutrition Examination Survey (Park et al, ). Biomedical experiments also indicated that permethrin, another pyrethroid, promoted weight gain and increased adipocyte size in male C57BL/6J mice during high‐fat diet feeding (Xiao et al, ); furthermore, exposure to bifenthrin, a type‐I pyrethroid, induced fat deposition and increased adipocyte diameter in C57BL/6J mice (Wei et al, ).…”

Section: Introductionmentioning

confidence: 99%

β‐Cypermethrin Alleviated the Inhibitory Effect of Medium from RAW 264.7 Cells on 3T3‐L1 Cell Maturation into Adipocytes

Wang

Jin

et al. 2020

Lipids

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Studies have elucidated that pyrethroids induce adipogenesis. It is also known that macrophages can affect the homeostasis of adipose tissue. However, whether and how the β-cypermethrin (β-CYP)-mediated inhibition of the macrophages affects adipogenesis remain unknown. To explore the effects of β-CYP on adipogenesis through modulating the function of macrophages, 3T3-L1 cells, a preadipocyte cell line, were exposed to culture medium from either RAW 264.7 cells, a macrophage cell line (RM), or β-CYP-treated RAW 264.7 cells (CRM). CRM decreased the inhibitory effects of RM treatment on cell proliferation and adipogenesis, as lipid accumulation, the CEBPA content, and Fasn and Acaca expression in 3T3-L1 cells were higher following CRM treatment than following RM treatment through the higher levels of the demethylated CEBPA promoter in 3T3-L1 cells. However, the medium from β-CYPand Nacetyl-L-cysteine-cotreated RAW 264.7 cells (CNRM) partially restored the inhibitory effects of RAW 264.7 cells on 3T3-L1 cells that had been reduced by CRM, indicating that β-CYP might reduce the cytotoxicity and inhibitory effects of RAW 264.7 cells on the adipogenesis of 3T3-L1 cells through elevating ROS levels in RAW 264.7 cells. Moreover, exposure to β-CYP downregulated the TNF-α secretion in RAW 264.7 cells. In conclusion, these data demonstrated that β-CYP affected the function of RAW 264.7 cells, alleviating their inhibitory effects on adipogenesis and CEBPA demethylation in 3T3-L1 cells. β-CYP might achieve these effects through downregulating the secretion of TNF-α via elevating ROS levels in RAW 264.7 cells. Our experiments provide a new perspective on the obesogenic effect of pyrethroids.

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Exposure to pesticides and the prevalence of diabetes in a rural population in Korea

Cited by 42 publications

References 36 publications

Dietary patterns of Brazilian farmers and their relation with sociodemographic, labor, and lifestyle conditions

Dietary patterns of Brazilian farmers and their relation with sociodemographic, labor, and lifestyle conditions

Increased risk of atherosclerosis associated with pesticide exposure in rural areas in Korea

β‐Cypermethrin Alleviated the Inhibitory Effect of Medium from RAW 264.7 Cells on 3T3‐L1 Cell Maturation into Adipocytes

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