Exposure to outdoor air pollution during trimesters of pregnancy and childhood asthma, allergic rhinitis, and eczema

Deng, Qihong; Lu, Chan; Li, Yuguo; Sundell, Jan; Norbäck, Dan

doi:10.1016/j.envres.2016.05.050

Cited by 251 publications

(130 citation statements)

References 68 publications

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“…Recent studies have focused on early-life risk factors and the development of allergic diseases later in life to understand the effect of exposure on the development of atopic disease. The association of prenatal and early-life exposures and the subsequent development of allergy-related outcomes with focuses on different breastfeeding characteristics [5], mode of delivery [6], the microbiome [7], indoor allergens [8], and air pollution exposure [9] during the first months and years of life have been previously reported. In several studies, the season of birth has also been associated with the risk of developing allergic disease including rhinitis [10, 11] and hay fever [12]; however, the mechanisms underlying such effects remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Early-Life Environmental Factors, IFN-γ Methylation Patterns, and Childhood Allergic Rhinitis

Rui

et al. 2019

Int Arch Allergy Immunol

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Background: While early-life risk factors are known to influence the risk of allergies, the biological mechanisms underlying this observation are unclear. The aim of this study was to examine whether DNA methylation in childhood could underlie the association between early-life risk factors and allergic rhinitis (AR). Methods: In total, 234 patients, aged 6 years, were recruited, i.e., 114 were patients with AR (AR group) and 120 healthy children without AR (NAR group). The DNA methylation patterns of the IFN-γ promoter regions in CD4+ cells were analyzed using bisulfite sequencing. The percentage of Th1 was investigated by flow cytometry. The relationship among DNA methylation, early-life environment, and AR was examined. Results: After adjusting for several likely confounders, there was a higher likelihood of AR in children who had mothers with allergies than in children who had nonallergic mothers (OR = 5.19; 95% CI 1.18–29.41), in children who were born in autumn or winter than in children who were born in the summer or spring (OR = 2.69; 95% CI 1.34–5.40), and in children who lived with indoor carpet or wallpaper than in children who lived without indoor carpet or wallpaper (OR = 4.14; 95% CI 2.05–8.30). Compared to the NAR group, the AR group had higher mean methylation levels of the promoter region in IFN-γY, and lower numbers of IFN-γ+CD4+ cells were associated with autumn-winter birthdates. The season of birth had an indirect effect on AR at 6 years, which was mediated by the mean IFN-γ promoter methylation level. Conclusions: This study suggests that early-life environments affect AR, and this is supported by the finding of IFN-γY methylation as a mediator of the effect of an individual’s season of birth on AR.

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Section: Introductionmentioning

confidence: 99%

Early-Life Environmental Factors, IFN-γ Methylation Patterns, and Childhood Allergic Rhinitis

Rui

et al. 2019

Int Arch Allergy Immunol

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“…18, 36 In our study, we report associations only during the first trimester of pregnancy, which corresponds to the pseudo-glandular stage of fetal lung development. During this period budding and branching of the tracheobronchial tree is completed and further structural formation of the conducting airways such as vascular, smooth muscle and mucosal glands formation occurs.…”

Section: Discussionmentioning

confidence: 72%

“…Recent epidemiological evidence demonstrates that exposure to ambient air pollution at different periods in pregnancy is associated with respiratory outcomes in childhood. 2, 17, 18 Our group showed that PM 2.5 exposure during the second trimester was associated with asthma at age 6 in children in Boston. 2 A study in China reported varying periods of importance for outdoor prenatal exposure to NO 2 and allergic or respiratory outcomes, with first trimester exposure associated with eczema, exposure in the second trimester associated with asthma, and third trimester exposure linked with allergic rhinitis.…”

Section: Introductionmentioning

confidence: 93%

“…2 A study in China reported varying periods of importance for outdoor prenatal exposure to NO 2 and allergic or respiratory outcomes, with first trimester exposure associated with eczema, exposure in the second trimester associated with asthma, and third trimester exposure linked with allergic rhinitis. 18 In a study in Spain, second trimester NO 2 exposure estimated using LUR was associated with reduced lung function at age 4.5 years and increased risk of low lung function (<80% of predicted forced expiratory volume in 1 second [FEV 1 ]). 17 Therefore, there is reason to expect that the particular timing of exposure during the prenatal period may be of importance.…”

Section: Introductionmentioning

confidence: 99%

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Prenatal particulate matter exposure and wheeze in Mexican children

Rosa

Just

Kloog

et al. 2017

Annals of Allergy, Asthma & Immunology

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“…The gestational period represents a critical window during which perturbation in immune system development could initiate atopic sensitization, AD, rhinitis, and/or wheezing (20,21). In particular, early-life pathologic processes is speculated to largely influence the phenotype of asthma (22).…”

Section: Home Indoor Dampnessmentioning

confidence: 99%

Linking childhood allergic asthma phenotypes with endotype through integrated systems biology: current evidence and research needs

Choi

Song

Zhang

2017

Reviews on Environmental Health

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Abstract Asthma and other complex diseases results from a complex web of interactions involving inflammation, immunity, cell cycle, apoptosis, and metabolic perturbations across multiple organ systems. The extent to which various degrees of the age at onset, symptom severity, and the natural progression of the disease reflect multiple disease subtypes, influenced by unique process of development remains unknown. One of the most critical challenges to our understanding stems from incomplete understanding of the mechanisms. Within this review, we focus on the phenotypes of childhood allergic asthma as the basis to better understand the endotype for quantitative define subtypes of asthma. We highlight some of the known mechanistic pathways associated with the key hallmark events before the asthma onset. In particular, we examine how the recent advent of multiaxial -omics technologies and systems biology could help to clarify our current understanding of the pathway. We review how a large volume of molecular, genomic data generated by multiaxial technologies could be digested to identify cogent pathophysiologic molecular networks. We highlight some recent successes in application of these technologies within the context of other disease conditions for therapeutic interventions. We conclude by summarizing the research needs for the predictive value of preclinical biomarkers.

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Exposure to outdoor air pollution during trimesters of pregnancy and childhood asthma, allergic rhinitis, and eczema

Cited by 251 publications

References 68 publications

Early-Life Environmental Factors, IFN-γ Methylation Patterns, and Childhood Allergic Rhinitis

Early-Life Environmental Factors, IFN-γ Methylation Patterns, and Childhood Allergic Rhinitis

Prenatal particulate matter exposure and wheeze in Mexican children

Linking childhood allergic asthma phenotypes with endotype through integrated systems biology: current evidence and research needs

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