Prenatal particulate matter exposure and wheeze in Mexican children

Rosa, Maria José; Just, Allan C.; Kloog, Itai; Pantic, Ivan; Schnaas, Lourdes; Lee, Alison; Bose, Sonali; Chiu, Yueh-Hsiu Mathilda; Hsu, Hsiao‐Hsien Leon; Coull, Brent A.; Schwartz, Joel; Cohen, Sheldon; Téllez-Rojo, Martha M.; Wright, Robert O.; Wright, Rosalind J.

doi:10.1016/j.anai.2017.06.016

Cited by 42 publications

(36 citation statements)

References 38 publications

(37 reference statements)

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“…In this vein, a number of recent studies have directly examined the link between the stress context and pollutant effect modification, including examination of specific vulnerability periods in each sex. Higher PM2.5 exposure during the first trimester was associated with increased risk of wheeze among children with mothers who reported high prenatal stress [130]. Prenatal nitrate exposure at 7-19 and 33-40 weeks gestation was associated with asthma in boys exposed to high prenatal stress [131].…”

Section: Vulnerability: Interactions With Sex Age and Non-chemicalmentioning

confidence: 92%

Air Pollution, Stress, and Allostatic Load: Linking Systemic and Central Nervous System Impacts

Thomson

2019

JAD

197

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Air pollution is a risk factor for cardiovascular and respiratory morbidity and mortality. A growing literature also links exposure to diverse air pollutants (e.g., nanoparticles, particulate matter, ozone, traffic-related air pollution) with brain health, including increased incidence of neurological and psychiatric disorders such as cognitive decline, dementia (including Alzheimer's disease), anxiety, depression, and suicide. A critical gap in our understanding of adverse impacts of pollutants on the central nervous system (CNS) is the early initiating events triggered by pollutant inhalation that contribute to disease progression. Recent experimental evidence has shown that particulate matter and ozone, two common pollutants with differing characteristics and reactivity, can activate the hypothalamic-pituitary-adrenal (HPA) axis and release glucocorticoid stress hormones (cortisol in humans, corticosterone in rodents) as part of a neuroendocrine stress response. The brain is highly sensitive to stress: stress hormones affect cognition and mental health, and chronic stress can produce profound biochemical and structural changes in the brain. Chronic activation and/or dysfunction of the HPA axis also increases the burden on physiological stress response systems, conceptualized as allostatic load, and is a common pathway implicated in many diseases. The present paper provides an overview of how systemic stress-dependent biological responses common to particulate matter and ozone may provide insight into early CNS effects of pollutants, including links with oxidative, inflammatory, and metabolic processes. Evidence of pollutant effect modification by non-chemical stressors (e.g., socioeconomic position, psychosocial, noise), age (prenatal to elderly), and sex will also be reviewed in the context of susceptibility across the lifespan.

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Section: Vulnerability: Interactions With Sex Age and Non-chemicalmentioning

confidence: 92%

Air Pollution, Stress, and Allostatic Load: Linking Systemic and Central Nervous System Impacts

Thomson

2019

JAD

197

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“…A recent area of growth in the research on asthma risk has been the exploration of the specific impact of air pollution exposure during gestation and in early life [ 29 , 30 , 31 , 32 ]. Several pathophysiological processes inform this body of work.…”

Section: Introductionmentioning

confidence: 99%

Early-Life Air Pollution Exposure, Neighborhood Poverty, and Childhood Asthma in the United States, 1990–2014

Kravitz‐Wirtz

Teixeira

Hajat

et al. 2018

IJERPH

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Ambient air pollution is a well-known risk factor of various asthma-related outcomes, however, past research has often focused on acute exacerbations rather than asthma development. This study draws on a population-based, multigenerational panel dataset from the United States to assess the association of childhood asthma risk with census block-level, annual-average air pollution exposure measured during the prenatal and early postnatal periods, as well as effect modification by neighborhood poverty. Findings suggest that early-life exposures to nitrogen dioxide (NO2), a marker of traffic-related pollution, and fine particulate matter (PM2.5), a mixture of industrial and other pollutants, are positively associated with subsequent childhood asthma diagnosis (OR = 1.25, 95% CI = 1.10–1.41 and OR = 1.25, 95% CI = 1.06–1.46, respectively, per interquartile range (IQR) increase in each pollutant (NO2 IQR = 8.51 ppb and PM2.5 IQR = 4.43 µ/m3)). These effects are modified by early-life neighborhood poverty exposure, with no or weaker effects in moderate- and low- (versus high-) poverty areas. This work underscores the importance of a holistic, developmental approach to elucidating the interplay of social and environmental contexts that may create conditions for racial-ethnic and socioeconomic disparities in childhood asthma risk.

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“…Secondly, PSI was used instead of individual pollutants such as SO 2 , NO 2 , CO and O 3 to represent the ambient air pollution. We note that it is important to investigate the role of these individual pollutants as their effects have been observed in other studies [ 10 , 11 , 32 ]. There are few studies that used PSI as an air quality indicator.…”

Section: Discussionmentioning

confidence: 91%

“…Our findings are in line with several other studies [ 28 , 29 , 30 , 31 ]. A Mexican study group reported that children born to mothers who were exposed to both higher PM 2.5 and stress during the first trimester had higher risk of current wheeze (relative risk (95% CI) = 1.35 (1.00–1.83)) [ 32 ]. Based on findings from a Spanish birth cohort, higher risks of lower respiratory tract infection (LRTI), wheezing and ear infection were reported in children whose mothers were exposed to NO 2 and benzene prenatally, especially during the second trimester (for NO 2 exposure, RR for LRTI (95% CI) 1.08 (1.02–1.15), wheezing = 1.05 (0.99–1.11), ear infection = 1.16 (0.98–1.37); for benzene exposure, LRTI = 1.10 (1.01–1.20), wheezing = 1.02 (0.96–1.09); ear infection = 1.13 (1.00–1.27)) [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Pregnancy Trimester-Specific Exposure to Ambient Air Pollution and Child Respiratory Health Outcomes in the First 2 Years of Life: Effect Modification by Maternal Pre-Pregnancy BMI

Soh

Goh

Teoh

et al. 2018

IJERPH

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Prenatal exposure to air pollution is associated with childhood respiratory health; however, no previous studies have examined maternal pre-pregnancy body mass index (BMI) as a potential effect modifier. We investigated whether maternal pre-pregnancy BMI modified the association of trimester-specific air pollution divided into quartiles of exposure (Q1–4) on respiratory health in the Growing Up in Singapore towards healthy Outcomes (GUSTO) study (n = 953) in 2-year-old children. For episodes of wheezing, children of overweight/obese mothers and who were exposed to particulate matter less than 2.5 μm (PM2.5) in the first trimester had an adjusted incidence rate ratio (IRR) (95% confidence interval (CI)) of 1.85 (1.23–2.78), 1.76 (1.08–2.85) and 1.90 (1.10–3.27) in quartile (Q) 2–4, with reference to Q1. This association is seen in the second trimester for bronchiolitis/bronchitis. The risk of ear infection in the first year of life was associated with exposure to PM2.5 in the first trimester with adjusted Odds Ratio (adjOR) (95% CI) = 7.64 (1.18–49.37), 11.37 (1.47–87.97) and 8.26 (1.13–60.29) for Q2–4, and similarly in the second year with adjOR (95% CI) = 3.28 (1.00–10.73) and 4.15 (1.05–16.36) for Q2–3. Prenatal exposure to air pollution has an enhanced impact on childhood respiratory health, and differs according to maternal pre-pregnancy BMI.

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Prenatal particulate matter exposure and wheeze in Mexican children

Cited by 42 publications

References 38 publications

Air Pollution, Stress, and Allostatic Load: Linking Systemic and Central Nervous System Impacts

Air Pollution, Stress, and Allostatic Load: Linking Systemic and Central Nervous System Impacts

Early-Life Air Pollution Exposure, Neighborhood Poverty, and Childhood Asthma in the United States, 1990–2014

Pregnancy Trimester-Specific Exposure to Ambient Air Pollution and Child Respiratory Health Outcomes in the First 2 Years of Life: Effect Modification by Maternal Pre-Pregnancy BMI

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