Exposure to multiple toxic metals and polycystic ovary syndrome risk: Endocrine disrupting effect from As, Pb and Ba

Liang, Chunmei; Zhang, Zhikang; Cao, Yu; Wang, Jieyu; Shen, Lingchao; Jiang, Tingting; Li, Danyang; Zou, Weiwei; Zong, Kai; Liang, Dan; Xu, Xiaofeng; Liu, Yajing; Tao, Fangbiao; Luo, Guiying; Ji, Dongmei; Cao, Yunxia

doi:10.1016/j.scitotenv.2022.157780

Cited by 19 publications

(9 citation statements)

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“…The balance of AEs and AEEs plays important roles in physiological functions [ 16 ]. Previous studies have indicated that AEs and AEEs are associated with female reproductive health [ 19 , 23 , 20 – 22 ]. However, at present, no studies have reported on the effect of AEs and AEEs on the ovarian reserve.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding AEEs, clinical trials have shown that supplementation with Cs can influence the ovarian response during the IVF process [ 20 ] and can affect on pregnancy and live birth rates [ 21 , 22 ]. A higher blood Ba concentration has been reported to be associated with a greater risk for polycystic ovarian syndrome (PCOS) [ 23 ]. The findings of these studies suggest the potentially important role of AE and AEEs in female reproductive health.…”

Section: Introductionmentioning

confidence: 99%

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Alkali and alkaline earth elements in follicular fluid and the likelihood of diminished ovarian reserve in reproductive-aged women: a case‒control study

Tian,

Li,

Liu

et al. 2024

J Ovarian Res

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Background Imbalances in alkali elements (AEs) and alkaline earth elements (AEEs) cause reproductive disorders. However, it remains unclear whether AEs/AEEs in follicular fluid have a relationship with the serious reproductive disorder known as diminished ovarian reserve (DOR). Methods A nested case‒control study was carried out in China. Follicular fluid samples from 154 DOR patients and 154 controls were collected and assessed for nine AEs/AEE levels. Both the mixed and single effects of the elements on DOR were estimated with a Bayesian kernel machine (BKMR) and logistic regressions. Results The DOR group had higher median concentrations of Li, Na, and K in follicular fluid (all P values < 0.05). The logistic regression showed that compared with their lowest tertile, the high tertiles of K [OR:2.45 (1.67–4.43)], Li [OR: 1.89 (1.06–3.42)], and Cs [OR: 1.97 (1.10–3.54)] were significantly associated with the odds of DOR. The BKMR model reported that the DOR likelihood increased linearly across the 25th through 75th percentiles of the nine-AE/AEE mixture, while the AE group contributed more to the overall effect. Conclusion This study revealed an association in which the likelihood of DOR increased with higher overall concentrations of AE/AEEs in follicular fluid. Among the nine detected elements, K, Li, and Cs exhibited significant individual associations with DOR. We provide new clues for the environmental factors on female fertility decline. Trial registration Retrospectively registered.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Alkali and alkaline earth elements in follicular fluid and the likelihood of diminished ovarian reserve in reproductive-aged women: a case‒control study

Tian,

Li,

Liu

et al. 2024

J Ovarian Res

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“…11 Emerging evidence has found an association between Pb exposure and metabolic disorders such as lipid accumulation, hyperglycemia and IR. 12,13 Significant positive associations between blood Pb levels and fasting blood glucose were identified in Pb exposed population. 14 Meanwhile, HFD is more prevalent than ever before and is projected to continue increasing, becoming a major contributor to diabetes, overweight and obesity.…”

Section: Introductionmentioning

confidence: 97%

“…Despite major initiatives to reduce environment pollution and levels of Pb in the environment, Pb pollution remains a major public health problem around the world 11 . Emerging evidence has found an association between Pb exposure and metabolic disorders such as lipid accumulation, hyperglycemia and IR 12,13 . Significant positive associations between blood Pb levels and fasting blood glucose were identified in Pb exposed population 14 .…”

Section: Introductionmentioning

confidence: 99%

Lead exposure aggravates glucose metabolism disorders through gut microbiota dysbiosis and intestinal barrier damage in high‐fat diet‐fed mice

Wang,

Gao,

Huo

et al. 2023

J Sci Food Agric

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BACKGROUNDLead (Pb) is an ancient toxic metal and is still a major public health issue. Our previous study found that Pb exposure promotes metabolic disorders in obese mice, but the molecular mechanisms remain unclear. The present study explored the effects of Pb exposure on glucose homeostasis in mice fed a normal diet (ND) and high‐fat diet (HFD) from the perspective of gut microbiota.RESULTSPb exposure had little effect on glucose metabolism in ND mice, but exacerbated hyperglycemia and insulin resistance, and impaired glucose tolerance in HFD mice. Pb exposure impaired intestinal tight junctions and mucin expression in HFD mice, increasing intestinal permeability and inflammation. Moreover, Pb exposure altered the composition and structure of the gut microbiota and decreased short‐chain fatty acids (SCFAs) levels in HFD mice. Correlation analysis revealed that the gut microbiota and SCFAs were significantly correlated with the gut barrier and glucose homeostasis. Furthermore, the fecal microbiota transplantation from Pb‐exposed HFD mice resulted in glucose homeostasis imbalance, intestinal mucosal structural damage and inflammation in recipient mice. However, Pb did not exacerbate the metabolic toxicity in HFD mice under depleted gut microbiota.CONCLUSIONThe findings of the present study suggest that Pb induces impairment of glucose metabolism in HFD mice by perturbing the gut microbiota. Our study offers new perspectives on the mechanisms of metabolic toxicity of heavy metals and demonstrates that the gut microbiota may be a target of action for heavy metal exposure. © 2023 Society of Chemical Industry.

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“…Male workers exposed to lead manifest higher blood lead levels (BLL), lower sperm count, and poor sperm motility compared to those without occupational lead exposure (18). By contrast, lead-exposed women are at higher risk of developing PCOS (19).…”

Section: Introductionmentioning

confidence: 99%

A global perspective of correlation between maternal blood lead levels and risks of preeclampsia: An updated systematic review and meta-analysis

Zhong

Yang

Chu

et al. 2022

Front. Public Health

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BackgroundPreeclampsia (PE) is a specific hypertensive disorder in pregnancy. Lead (Pb) is a heavy metal that affects women's reproductive health. However, it is unclear whether lead exposure during can predispose maternal risk of developing preeclampsia. This systematic review and meta-analysis study aimed to explore the association.MethodsWe searched studies from three databases (PubMed, Web of Science, Embase). Only case-control, cross-sectional, and cohort studies reporting maternal blood lead levels (BLL) and PE were included from database inception to 31st July 2022. Pregnant women with blood lead levels measured were eligible. Those healthy pregnant women who did not develop preeclampsia were assessed as comparators. Letters, comments, case reports, and reviews were excluded. Newcastle-Ottawa Scale (NOS) and its adaptive form were applied for assessment. The random-effects method (REM) was applied to calculate the standardized mean difference (SMD) with a 95% confidence interval (CI). Stata 16.0 and RevMan 5.3 were the software used for data extraction and analysis.Results25 studies out of 1,808 articles made the finalist for systematic reviews, of which 21 underwent further quantity analysis. A total of 1,533 preeclamptic women and 10,998 healthy pregnant controls were included in the meta-analysis. The overall result revealed that maternal lead exposure was significantly higher in women with preeclampsia (SMD: 1.06, 95% CI 0.69, 1.43); (I2 = 96.40%; P = 0.000).ConclusionThis study demonstrates that maternal lead exposure is associated with preeclampsia during pregnancy. The association is present even in low blood lead levels. The conclusion should be taken seriously and women should avoid unexpected exposure to a lead-containing environment as much as possible.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=347220, identifier: CRD42022347220.

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Exposure to multiple toxic metals and polycystic ovary syndrome risk: Endocrine disrupting effect from As, Pb and Ba

Cited by 19 publications

References 46 publications

Alkali and alkaline earth elements in follicular fluid and the likelihood of diminished ovarian reserve in reproductive-aged women: a case‒control study

Alkali and alkaline earth elements in follicular fluid and the likelihood of diminished ovarian reserve in reproductive-aged women: a case‒control study

Lead exposure aggravates glucose metabolism disorders through gut microbiota dysbiosis and intestinal barrier damage in high‐fat diet‐fed mice

A global perspective of correlation between maternal blood lead levels and risks of preeclampsia: An updated systematic review and meta-analysis

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