A global perspective of correlation between maternal blood lead levels and risks of preeclampsia: An updated systematic review and meta-analysis

Zhong, Zixing; Yang, Qingmei; Chu, Li; Chen, Xiaohong; Zhou, Feifei

doi:10.3389/fpubh.2022.1072052

Cited by 6 publications

(5 citation statements)

References 62 publications

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“…However, we also noted some limitations in our study. The studies that met the inclusion criteria were still limited compared to other heavy metal studies (Zhong, et al 2022), this con ned us from exploring deeper. Furthermore, some studies reported the correlation between Cd and preeclampsia but did not report their data completely, and hence we could not pool them together for further analysis (Kovalchuk, et al 2013;Osorio-Yañez, et al 2016).…”

Section: Discussionmentioning

confidence: 99%

The relationship between cadmium exposure and preeclampsia: A systematic review and meta-analysis

Li,

Yang,

Wang

et al. 2023

Preprint

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Cadmium (Cd) is a heavy metal that has been associated with several disorders in humans. Preeclampsia is a major cause of maternal mortality worldwide. Despite numerous studies on the subject, the association between Cd exposure and preeclampsia remains elusive. To better understand this relationship, we conducted a systematic review and meta-analysis of eligible studies from five databases (PubMed, Embase, Web of Science, Scopus, and CNKI) from their inception to September 10, 2022. The quality of these studies was evaluated using the Newcastle-Ottawa quality assessment scale (NOS). We calculated overall standardized mean differences (SMDs) and 95% confidence intervals (CIs) using random-effects models. Sensitivity analyses were performed to assess the robustness of our results. We also evaluated publication bias using Egger’s and Begg’s tests. Additionally, we conducted meta-regression and subgroup analyses to identify potential sources of heterogeneity among studies. Our analysis included a total of 17 studies with 10,373 participants. We found a significant association between maternal cadmium exposure and the risk of preeclampsia (SMD 0.27, 95% CI 0.09–0.44, p < 0.001). No significant publication bias was detected in either Begg’s or Egger’s tests. Meta-regression suggested that factors such as geographical location, year of publication, cadmium samples, sample size, and measurement methods did not contribute to heterogeneity between studies. Our findings suggest that maternal cadmium exposure is associated with an increased risk of preeclampsia. Further high-quality clinical studies and animal experiments are needed to better understand this association.

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Section: Discussionmentioning

confidence: 99%

The relationship between cadmium exposure and preeclampsia: A systematic review and meta-analysis

Li,

Yang,

Wang

et al. 2023

Preprint

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“…However, we also noted some limitations in our study. The studies that met the inclusion criteria were still limited compared to other heavy metal studies (83), which confined us from exploring deeper. Furthermore, some studies reported the correlation between Cd and preeclampsia but did not report their data completely, and hence, we could not pool them together for further analysis (36,38).…”

Section: Discussionmentioning

confidence: 99%

The relationship between cadmium exposure and preeclampsia: a systematic review and meta-analysis

Li,

Luo,

Yang

et al. 2023

Front. Med.

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BackgroundCadmium (Cd) is a heavy metal associated with several human disorders. Preeclampsia is a major cause of maternal mortality worldwide. The association between maternal Cd exposure and preeclampsia remains elusive.MethodsTo better understand this relationship, we conducted a systematic review and meta-analysis of eligible studies from five databases (PubMed, Embase, Web of Science, Scopus, and CNKI) from their inception to September 10, 2022. The quality of these studies was evaluated using the Newcastle-Ottawa quality assessment scale (NOS). We use random-effects models to calculate overall standardized mean differences (SMDs) and 95% confidence intervals (CIs). Sensitivity analyses were performed to assess the robustness of our results. We also evaluated publication bias using Egger’s and Begg’s tests. Additionally, we conducted meta-regression and sub-group analyses to identify potential sources of heterogeneity between studies.ResultsOur analysis included a total of 17 studies with 10,373 participants. We found a significant association between maternal cadmium exposure and the risk of preeclampsia (SMD 0.27, 95% CI 0.09–0.44, p < 0.01). No significant publication bias was detected in Begg’s or Egger’s tests. Meta-regression suggested that geographical location, year of publication, cadmium samples, sample size, and measurement methods did not contribute to heterogeneity between studies.ConclusionOur findings suggest that maternal blood cadmium levels are associated with an increased risk of preeclampsia. In contrast, the pregnant women’s urine or placental levels of cadmium may not suggest preeclamptic risk during pregnancy. Further high-quality clinical studies and animal experiments are needed to understand this association better.Systematic review registrationPROSPERO, https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=361291, identifier: CRD42022361291.

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“…There are no known safe levels of exposure to toxic metals [17] and exposure is associated with a number of adverse biological effects including inflammation and oxidative stress [18,19]. Exposure to toxic metals during pregnancy may be associated with the development of pregnancy complications (gestational diabetes, hypertensive disorders) as well as adverse birth outcomes including preterm birth and small for gestational age [20][21][22][23]. Moreover, these effects may persist well into later life, for both the gestational parent and child, potentially contributing to life-long risk of developing several chronic diseases (Type 2 Diabetes, hypertension).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D and Toxic Metals in Pregnancy - a Biological Perspective

Fisher,

Weiler,

Kuiper

et al. 2024

Curr Epidemiol Rep

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Purpose of Review To discuss the potential biological mechanisms between vitamin D and toxic metals and summarize epidemiological studies examining this association in pregnant women. Recent Findings We identified four plausible mechanisms whereby vitamin D and toxic metals may interact: nephrotoxicity, intestinal absorption of metals, endocrine disruption, and oxidative stress. Few studies have examined the association between vitamin D and toxic metals in pregnant women. North American studies suggest that higher vitamin D status early in pregnancy are associated with lower blood metals later in pregnancy. However, a trial of vitamin D supplementation in a pregnant population, with higher metal exposures and lower overall nutritional status, does not corroborate these findings. Summary Given ubiquitous exposure to many toxic metals, nutritional intervention could be a means for prevention of adverse outcomes. Future prospective studies are needed to establish a causal relationship and clarify the directionality of vitamin D and metals.

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A global perspective of correlation between maternal blood lead levels and risks of preeclampsia: An updated systematic review and meta-analysis

Cited by 6 publications

References 62 publications

The relationship between cadmium exposure and preeclampsia: A systematic review and meta-analysis

The relationship between cadmium exposure and preeclampsia: A systematic review and meta-analysis

The relationship between cadmium exposure and preeclampsia: a systematic review and meta-analysis

Vitamin D and Toxic Metals in Pregnancy - a Biological Perspective

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