Exposure to high-fat diet since post-weaning induces cardiometabolic damage in adult rats

Fiorino, Patricia; Américo, Anna Laura Viacava; Muller, Cynthia R.; Evangelista, Fabiana S.; Santos, Fernando dos; Leite, Ana Paula de Oliveira; Farah, Vera

doi:10.1016/j.lfs.2016.07.001

Cited by 10 publications

(12 citation statements)

References 40 publications

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“…Another potential mechanism is that higher maternal weight status and BP in early postpartum reflect dietary patterns that inform greater infant weight gain via breast milk composition. The maternal obesity‐hypertension phenotype has been attributed to dietary (eg, high‐fat and high‐fructose consumption) and subsequent metabolic (eg, hyperleptinaemia and hypertriglyceridaemia) factors . The same dietary and metabolic factors are detectable in breast milk and have been shown to influence infant obesity risk through breast milk exposure .…”

Section: Discussionmentioning

confidence: 99%

“…c Tests of significance between groups were based on chi-square test. high-fat and high-fructose consumption) [22][23][24] and subsequent metabolic (eg, hyperleptinaemia and hypertriglyceridaemia) factors. 23,25 The same dietary and metabolic factors are detectable in breast milk and have been shown to influence infant obesity risk through breast milk exposure.…”

Section: Discussionmentioning

confidence: 99%

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Maternal blood pressure mediates the association between maternal obesity and infant weight gain in early postpartum

et al. 2019

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Summary Background It is unknown to what extent higher maternal blood pressure (BP) in early postpartum impacts the relationship between higher maternal weight status and greater infant weight gain in early postpartum. Objective To evaluate the mediating role of higher maternal BP at 1 month postpartum on the association between higher maternal weight status at 1 month postpartum and greater infant weight gain over 6 months postpartum. Methods Participants were 169 Hispanic mother‐infant pairs. Maternal body mass index (BMI) and BP were assessed at 1 month postpartum. Infant weight was measured at 1 and 6 months postpartum to calculate weight‐for‐age z scores (WAZ). Multiple linear regression models were used for prediction, and Sobel test was used to determine mediation. Results Controlling for maternal pre‐pregnancy BMI, age, delivery mode, infant sex, and infant birth weight revealed that both maternal BMI (β = .29) and BP (β = .32) predicted infant WAZ gain (both P ≤ .03). However, the relationship between infant WAZ gain and maternal BMI was no longer significant after further adjustment for maternal BP, which remained significant (P < .05). Maternal BP explained 23.6% (Sobel T = 2.01) of the association between maternal BMI at 1 month and infant WAZ gain over 6 months. Conclusion Our data suggest that higher maternal weight status at 1 month postpartum is related to greater infant weight gain over 6 months postpartum, and this relationship is mediated by higher maternal BP at 1 month postpartum.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Maternal blood pressure mediates the association between maternal obesity and infant weight gain in early postpartum

et al. 2019

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“…More recently, the involvement of adiponectin in the regulation of TNF-α, affecting coronary and aortic endothelium functions, has been demonstrated [50]. Previous studies showed that the concentration of adiponectin was decreased in rats on a high-fat diet [51,52,53,54], and it has been reported that plasma adiponectin levels are negatively correlated with body fat mass in humans [55]. In contrast, we failed to detect any changes in plasma adiponectin concentrations in the h-SD group or in its receptor in the femoral artery (AdipoR1).…”

Section: Discussionmentioning

confidence: 99%

Circulating Concentrations of Adipocytokines and Their Receptors in the Isolated Corpus Cavernosum and Femoral Artery from Trained Rats on a High-Fat Diet

Sponton¹,

Silva

Araújo³

et al. 2017

J Vasc Res

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Background: The aim of the present study was to evaluate different signaling pathways by which exercise training would interfere in endothelial function in obesity. Therefore, we examined adipocytokine levels and their receptors in the corpus cavernosum and femoral artery from trained rats on a high-fat diet. Methods: Functional experiments were performed in control sedentary and trained rats, and sedentary (h-SD) and trained male Wistar rats on a high-fat diet (h-TR). Nitric oxide (NO) and reactive oxygen species (ROS) were evaluated in vascular tissue. Circulating adipocytokines and their receptors were analyzed. Results: In the h-SD group, the maximal responses to acetylcholine (ACh) were reduced in the femoral artery and corpus cavernosum as well as the electrical field stimulation, accompanied by an increase in circulating insulin, leptin, TNF-α, MCP-1, and PAI-1. Downregulation of ObR protein expression in the femoral artery was observed without alterations in AdipoR1 and TNFR1 in both preparations. A positive effect was observed in the h-TR group regarding the relaxation response to ACh and circulating adipocytokines, resulting in increased NO production and reduced ROS generation. Exercise restored the ObR protein expression only in the femoral artery. Conclusion: Aerobic exercise training ameliorated the inflammatory adipocytokines and restored the relaxation responses in the corpus cavernosum and femoral artery in rats on a high-fat diet.

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“…In the case of high-fat diet, adult cardiac alterations including increased heart rate were described when the exposure occurred after weaning. 55 Another study which compared in utero and post-weaning period of exposure to a high-fat high-sugar diet showed that exposure in the post-weaning period has a more profound effect on offspring weight gain and glucose tolerance than maternal overnutrition. 56 The analyses of metabolic alterations suggest that post-weaning period is critical in the altered programming of offspring health by nutrition.…”

Section: Early Exposure To Environmental Challenges Induces Cardiac Dmentioning

confidence: 99%

At the heart of programming: the role of micro-RNAs

Siddeek

Mauduit

Yzydorczyk

et al. 2018

J Dev Orig Health Dis

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Epidemiological and experimental observations tend to prove that environment, lifestyle or nutritional challenges influence heart functions together with genetic factors. Furthermore, when occurring during sensitive windows of heart development, these environmental challenges can induce an 'altered programming' of heart development and shape the future heart disease risk. In the etiology of heart diseases driven by environmental challenges, epigenetics has been highlighted as an underlying mechanism, constituting a bridge between environment and heart health. In particular, micro-RNAs which are involved in each step of heart development and functions seem to play a crucial role in the unfavorable programming of heart diseases. This review describes the latest advances in micro-RNA research in heart diseases driven by early exposure to challenges and discusses the use of micro-RNAs as potential targets in the reversal of the pathophysiology.

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Exposure to high-fat diet since post-weaning induces cardiometabolic damage in adult rats

Cited by 10 publications

References 40 publications

Maternal blood pressure mediates the association between maternal obesity and infant weight gain in early postpartum

Maternal blood pressure mediates the association between maternal obesity and infant weight gain in early postpartum

Circulating Concentrations of Adipocytokines and Their Receptors in the Isolated Corpus Cavernosum and Femoral Artery from Trained Rats on a High-Fat Diet

At the heart of programming: the role of micro-RNAs

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