2002
DOI: 10.3727/096504002108747926
|View full text |Cite
|
Sign up to set email alerts
|

Exposure to Global System for Mobile Communication (GSM) Cellular Phone Radiofrequency Alters Gene Expression, Proliferation, and Morphology of Human Skin Fibroblasts

Abstract: Human skin fibroblasts were exposed to global system for mobile communication (GSM) cellular phone radiofrequency for 1 h. GSM exposure induced alterations in cell morphology and increased the expression of mitogenic signal transduction genes (e.g., MAP kinase kinase 3, G2/mitotic-specific cyclin G1), cell growth inhibitors (e.g., transforming growth factor-beta), and genes controlling apoptosis (e.g., bax). A significant increase in DNA synthesis and intracellular mitogenic second messenger formation matched … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

4
54
0
1

Year Published

2004
2004
2013
2013

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 90 publications
(59 citation statements)
references
References 0 publications
4
54
0
1
Order By: Relevance
“…Induction of specific genes in cultured cells in response to mobile phone MWs has been reported [Goswami et al, 1999;Pacini et al, 2002]. Induction of the c-fos gene was observed in rat cerebral cortex at the thermal levels of exposure exceeding the specific absorbed rates (SARs), usually observed during mobile telephony [Hossmann and Hermann, 2003].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Induction of specific genes in cultured cells in response to mobile phone MWs has been reported [Goswami et al, 1999;Pacini et al, 2002]. Induction of the c-fos gene was observed in rat cerebral cortex at the thermal levels of exposure exceeding the specific absorbed rates (SARs), usually observed during mobile telephony [Hossmann and Hermann, 2003].…”
Section: Introductionmentioning
confidence: 99%
“…There is growing evidence for nonthermal effects of MWs that suggests possible relationship of MW exposure with adverse health effects [Navarro et al, 2003;Santini et al, 2003;Hallberg and Johansson, 2004], immune response in human lymphocytes [Dabrowski et al, 2003], permeability of BBB in rat brains [Persson et al, 1997], increase in calcium ion efflux and ornithine decarboxylase (ODC) activity in brains of exposed rats [Paulraj and Behari, 2002], release of manganese and zinc ions in the serum of the exposed rats [Aksen et al, 2004], decreases in the reproductive capacity of Drosophila melanogaster [Panagopoulos et al, 2004], formation of dicentric chromosomes among mobile users [Gadhia et al, 2003], gene expression in human skin fibroblasts [Pacini et al, 2002], and stress response in human epithelial amnion (AMA) cells [Kwee et al, 2001]. Recent data provided evidence for neuronal damage in both the cortex, the hippocampus and the basal ganglia in the brains of exposed rats [Salford et al, 2003;Ilhan et al, 2004].…”
Section: Introductionmentioning
confidence: 99%
“…So far, there are a lot of investigations on biological responses to the EM (Electromagnetic) radiation. There is a wide range of data documenting the ability of EM radiation to affect the biochemical and molecular mechanisms of cells both in vitro and in vivo with effects independent of thermal phenomena such as, altered cell growth [1], exocytosis [2], gene expression [3], chromosomal instability [4] and the expression of heat shock proteins [5,6]. The effects of EM radiations on human body are generally accepted.…”
Section: Introductionmentioning
confidence: 99%
“…Considered as nonthermal GSM-RFR effects, yet with power absorptions of >1 W/Kg, are influences on human skin fibroblast morphology and cell cycle related gene expression [Pacini et al, 2002], on human endothelial cell stress responses [Leszczynski et al, 2002], as well as on chicken embryo hsp70 expression and cytoprotection against hypoxia [Di Carlo et al, 2002]. At the frequency and power density tested in this study, GSM-like RFR seems to have influenced the regulation of the expression of critical morphogenetic factors, such as the BMP related genes, in newborn rat kidneys after exposure to this type of radiation during the early stages of embryonal development.…”
Section: Discussionmentioning
confidence: 99%