Exposure to Fine Particulate Air Pollution Causes Vascular Insulin Resistance by Inducing Pulmonary Oxidative Stress

Haberzettl, Petra; O’Toole, Timothy E.; Bhatnagar, Aruni; Conklin, Daniel J.

doi:10.1289/ehp212

Cited by 212 publications

(138 citation statements)

References 45 publications

(79 reference statements)

Supporting

Mentioning

125

Contrasting

Unclassified

Order By: Relevance

“…A spillover effect is consistent with recent observations showing that oxidants generated in the lung by PM exposure could accelerate the formation of atherosclerotic lesions 147 and that increased superoxide dismutation in the lung could prevent PM-induced insulin resistance. 148 Additionally, activation of several lung receptors and nerve endings by PM could lead to change in heart rate, heart rate variability and electrocardiographic changes reflective of an increase in sympathetic tone. Such changes and the resulting hemodynamic and electrophysiological changes could account for the acute cardiovascular effects of PM.…”

Section: The Social Environmentmentioning

confidence: 99%

Environmental Determinants of Cardiovascular Disease

Bhatnagar

2017

Circulation Research

Self Cite

413

268

View full text Add to dashboard Cite

Many features of the environment have been found to exert an important influence on cardiovascular disease (CVD) risk, progression, and severity. Changes in the environment due to migration to different geographic locations, modifications in lifestyle choices, and shifts in social policies and cultural practices alter CVD risk, even in the absence of genetic changes. Nevertheless, the cumulative impact of the environment on CVD risk has been difficult to assess and the mechanisms by which some environment factors influence CVD remain obscure. Human environments are complex; and their natural, social and personal domains are highly variable due to diversity in human ecosystems, evolutionary histories, social structures, and individual choices. Accumulating evidence supports the notion that ecological features such as the diurnal cycles of light and day, sunlight exposure, seasons, and geographic characteristics of the natural environment such altitude, latitude and greenspaces are important determinants of cardiovascular health and CVD risk. In highly developed societies, the influence of the natural environment is moderated by the physical characteristics of the social environments such as the built environment and pollution, as well as by socioeconomic status and social networks. These attributes of the social environment shape lifestyle choices that significantly modify CVD risk. An understanding of how different domains of the environment, individually and collectively, affect CVD risk could lead to a better appraisal of CVD, and aid in the development of new preventive and therapeutic strategies to limit the increasingly high global burden of heart disease and stroke.

show abstract

Section: The Social Environmentmentioning

confidence: 99%

Environmental Determinants of Cardiovascular Disease

Bhatnagar

2017

Circulation Research

Self Cite

413

268

View full text Add to dashboard Cite

show abstract

“…In addition it has been suggested that ultrafine/nanosized particles or soluble particle constituents could enter the bloodstream and affect cardiovascular and metabolic health by direct interactions (Figure 1) [8]. This is supported by studies that show for instance the critical role of oxidative stress in mediating PM-induced vascular and metabolic dysfunction [17,18] and our recent studies that show that averting pulmonary oxidative stress prevented PM 2.5 -induced vascular inflammation and insulin resistance and restored endothelial progenitor cell number and function [13,19]. …”

Section: Introductionmentioning

confidence: 69%

Circadian toxicity of environmental pollution. Inhalation of polluted air to give a precedent

Haberzettl

2018

Current Opinion in Physiology

Self Cite

View full text Add to dashboard Cite

Exposures to environmental stressors that derive from pollution (e.g. air, light) or lifestyle choices (e.g. diet, activity, 24-hour-×−7-day) are associated with adverse human health outcomes. For instance, there is evidence that air pollution exposure and changes in sleep/wake pattern increase the risk for vascular and cardiometabolic disorders. Interestingly, air pollution exposure affects pulmonary and cardiovascular functions that follow circadian rhythmicity and increases the risk for pulmonary and cardiovascular events that occur in diurnal patterns suggesting a link between air pollution induced cardiovascular and pulmonary injury and changes in circadian rhythm. Indeed, recent research identified circadian rhythm as an air pollution target and circadian rhythm as factor that increases air pollution sensitivity. Using air pollution exposure as precedent, this review highlights research on how environmental pollution affect circadian rhythm and how circadian rhythm affects the toxicity of environmental stressors.

show abstract

“…Studies conducted in several countries, such as Europe, America, and Asia reported strong associations among exposure to air pollutants, insulin resistance, obesity, and diabetes with women overrepresented in the affected groups [165][166][167][168][169][170]. These findings have also been recapitulated in animal models, where exposure to particulate matter resulted in increased insulin resistance followed by a high-fat diet [171][172][173], and these effects were associated with inflammation triggered by mechanisms involving pulmonary oxidative stress [174].…”

Section: Outdoor Air Pollution and Lung Healthmentioning

confidence: 90%

Understanding the Intersection of Environmental Pollution, Pneumonia, and Inflammation: Does Gender Play a Role?

Silveyra¹,

Fuentes²,

Rivera³

2017

Contemporary Topics of Pneumonia

View full text Add to dashboard Cite

Accumulating evidence indicates that exposure to air pollution is associated with increased mortality from respiratory disease. Exposure to ambient pollutants, such as ozone, particulate matter, sulfur dioxide, nitrogen dioxide, and other agents has been associated with decrease in lung function and immunity, and with increased rates of hospitalization for lung disease, including pneumonia. Furthermore, sex differences in frequency and severity of pulmonary disease and infection have been reported, suggesting a role of sex hormones in mediating these differences. Pneumonia, which is commonly caused by bacterial infection and subsequent lung inflammation leading to hospitalization and death, occurs at different rates in men and women. In this context, male and female hormones can have direct effects on the immunity system by binding to receptors in immune cells, and these responses can be modulated by environmental exposures. This chapter summarizes clinical, animal, and epidemiological studies linking exposure to air pollution and pneumonia in both males and females. Understanding sex-specific mechanisms in pneumonia pathogenesis and environmental responses can help in the development of more effective therapeutics and treatment options to reduce negative health outcomes in men and women.

show abstract

Exposure to Fine Particulate Air Pollution Causes Vascular Insulin Resistance by Inducing Pulmonary Oxidative Stress

Cited by 212 publications

References 45 publications

Environmental Determinants of Cardiovascular Disease

Environmental Determinants of Cardiovascular Disease

Circadian toxicity of environmental pollution. Inhalation of polluted air to give a precedent

Understanding the Intersection of Environmental Pollution, Pneumonia, and Inflammation: Does Gender Play a Role?

Contact Info

Product

Resources

About