Exposure to fatty acids modulates interferon production by intraepithelial lymphocytes

Hara, Yuriko; Miura, Soichiro; Komoto, Shunsuke; Inamura, Toshiaki; Koseki, Seiichiro; Watanabe, Chikako; Hokari, Ryota; Tsuzuki, Yoshikazu; Ogino, Takashi; Nagata, Hiroshi; Hachimura, Satoshi; Kaminogawa, Shuichi; Ishii, Hiromasa

doi:10.1016/s0165-2478(03)00007-5

Cited by 32 publications

(34 citation statements)

References 31 publications

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“…We observed that lymph node T-cells from control animals responded to AA supplementation by decreasing IFN-c production. A previous report indicated that AA attenuated the anti-CD3-induced release of IFN-c by intraepithelial lymphocytes [30]. However, when T-cells from colitis animals were stimulated with anti-CD3x antibody, we observed an increase in IFN-c production.…”

Section: Discussioncontrasting

confidence: 69%

Perinodal Adipose Tissue and Mesenteric Lymph Node Activation During Reactivated TNBS-Colitis in Rats

et al. 2011

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Fatty acid analysis of PAT reveals an increase of ω-6 polyunsaturated fatty acids during colits, such as linoleic acid, gamma-linolenic acid and arachidonic acid. ω-6 arachidonic acid was not increased in lymph node cells or serum. PAT also produces elevated levels of pro- and anti-inflammatory adipokines during colitis. Lymph node cells release high levels of IFN-γ and TNF-α but not IL-10, characterizing the predominant Th-1 response associated with this disease. Nevertheless, T cells from animals with colitis demonstrated increased IFN-γ production via a COX-2-dependent mechanism after supplementation with ω-6 arachidonic acid, suggesting that PAT modification could contribute to the lymph node cell activation observed during colitis.

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Section: Discussioncontrasting

confidence: 69%

Perinodal Adipose Tissue and Mesenteric Lymph Node Activation During Reactivated TNBS-Colitis in Rats

et al. 2011

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“…At the heart of these observations is the constitutive activation of the AKT kinase, which can inactivate several different apoptotic pathways, and the loss of the AKT regulator and tumor suppressor, PTEN. [50][51][52][53] Based on our array studies, PTEN message levels are not significantly reduced in patients as compared with controls (data not shown), although we have not determined whether protein levels are also unchanged.…”

Section: Significance Of the Selected Genesmentioning

confidence: 87%

Quantitative PCR on 5 genes reliably identifies CTCL patients with 5% to 99% circulating tumor cells with 90% accuracy

Nebozhyn

Loboda

Kari

et al. 2006

Blood

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We previously identified a small number of genes using cDNA arrays that accurately diagnosed patients with Sé zary Syndrome (SS), the erythrodermic and leukemic form of cutaneous T-cell lymphoma (CTCL). We now report the development of a quantitative real-time polymerase chain reaction (qRT-PCR) assay that uses expression values for just 5 of those genes: STAT4, GATA-3, PLS3, CD1D, and TRAIL. qRT-PCR data from peripheral blood mononuclear cells (PBMCs) accurately classified 88% of 17 patients with high blood tumor burden and 100% of 12 healthy controls in the training set using Fisher linear discriminant analysis (FLDA). The same 5 genes were then assayed on 56 new samples from 49 SS patients with blood tumor burdens of 5% to 99% and 69 samples from 65 new healthy controls. The average accuracy over 1000 resamplings was 90% using FLDA and 88% using support vector machine (SVM). We also tested the classifier on 14 samples from patients with CTCL with no detectable peripheral involvement and 3 patients with atopic dermatitis with severe erythroderma. The accuracy was 100% in identifying these samples as non-SS patients. These results are the first to demonstrate that gene expression profiling by quantitative PCR on a selected number of critical genes can be employed to molecularly diagnosis SS. (Blood. 2006;107:3189-3196)

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“…Finally, in humans both in vitro and in vivo studies have shown that long-chain polyunsaturated fatty acids, particularly eicosapentaenoic acid suppress production and release of tumor necrosis factor (TNF), Interleukins, and IFNs [65]. Exposure to long-chain fatty acids decrease the production of IFN-gamma by stimulated intestinal intraepithelial lymphocytes, but oleic acid seems to be less effective at decreasing interferon production, since more concentration of this fatty acid is required to decrease the production when compared with other long-chain fatty acids such as ARA [66]. A higher concentration of LA is required to decrease the production of interferon when compared with ARA [66].…”

Section: Discussionmentioning

confidence: 99%

Total substitution of fish oil by vegetable oils in gilthead sea bream (Sparus aurata) diets: Effects on hepatic Mx expression and some immune parameters

Montero

Grasso

Izquierdo

et al. 2008

Fish & Shellfish Immunology

150

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Exposure to fatty acids modulates interferon production by intraepithelial lymphocytes

Cited by 32 publications

References 31 publications

Perinodal Adipose Tissue and Mesenteric Lymph Node Activation During Reactivated TNBS-Colitis in Rats

Perinodal Adipose Tissue and Mesenteric Lymph Node Activation During Reactivated TNBS-Colitis in Rats

Quantitative PCR on 5 genes reliably identifies CTCL patients with 5% to 99% circulating tumor cells with 90% accuracy

Total substitution of fish oil by vegetable oils in gilthead sea bream (Sparus aurata) diets: Effects on hepatic Mx expression and some immune parameters

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