Perinodal Adipose Tissue and Mesenteric Lymph Node Activation During Reactivated TNBS-Colitis in Rats

Acedo, Simone Coghetto; Gotardo, Érica Martins Ferreira; Lacerda, Janilda Martins; Oliveira, Caroline Candida de; Carvalho, Patrícia de Oliveira; Gambero, Alessandra

doi:10.1007/s10620-011-1644-8

Cited by 20 publications

(17 citation statements)

References 33 publications

(37 reference statements)

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“…Previous studies documented that TNBS-induced experimental colitis resembles the changes described in CD patients which were accompanied by an increased expression of proinflammatory mediators in the mesenteric fat depots [32,40,41,42]. Our present study is in keeping with the previous findings on leptin expressed in mWAT in rodents with experimental colitis and in CD patients [42,43,44,45,46,47,48,49,50,51,52].…”

Section: Discussionsupporting

confidence: 92%

Beneficial Effect of Voluntary Exercise on Experimental Colitis in Mice Fed a High-Fat Diet: The Role of Irisin, Adiponectin and Proinflammatory Biomarkers

et al. 2017

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Inflammatory bowel diseases (IBDs) are a heterogeneous group of disorders exhibited by two major phenotypic forms: Crohn‘s disease and ulcerative colitis. Although the aetiology of IBD is unknown, several factors coming from the adipose tissue and skeletal muscles, such as cytokines, adipokines and myokines, were suggested in the pathogenesis of ulcerative colitis; however, it has not been extensively studied whether voluntary exercise can ameliorate that disorder. We explored the effect of moderate exercise (i.e., voluntary wheel running) on the disease activity index (DAI), colonic blood flow (CBF), plasma irisin and adiponectin levels and real-time PCR expression of proinflammatory markers in mesenteric fat in mice with 2,4,6-trinitrobenzenesulfonic acid (TNBS) colitis fed a high-fat diet (HFD) compared to those on a standard chow diet (SD). Macroscopic and microscopic colitis in sedentary SD mice was accompanied by a significant fall in CBF, some increase in colonic tissue weight and a significant increase in the plasma levels of tumour necrosis factor-alpha (TNF-α), IL-6, monocyte chemotactic protein 1 (MCP-1) and IL-13 (p < 0.05). In sedentary HFD mice, colonic lesions were aggravated, colonic tissue weight increased and the plasma TNF-α, IL-6, MCP-1, IL-1β and leptin levels significantly increased. Simultaneously, a significant decrease in the plasma irisin and adiponectin levels was observed in comparison with SD mice (p < 0.05). Exercise significantly decreased macroscopic and microscopic colitis, substantially increased CBF and attenuated the plasma TNF-α, IL-6, MCP-1, IL-1β and leptin levels while raising the plasma irisin and the plasma and WAT concentrations of adiponectin in HFD mice (p < 0.05). We conclude that: (1) experimental colitis is exacerbated in HFD mice, possibly due to a fall in colonic microcirculation and an increase in the plasma and mesenteric fat content of proinflammatory biomarkers; and (2) voluntary physical activity can attenuate the severity of colonic damage in mice fed a HFD through the release of protective irisin and restoration of plasma adiponectin.

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Section: Discussionsupporting

confidence: 92%

Beneficial Effect of Voluntary Exercise on Experimental Colitis in Mice Fed a High-Fat Diet: The Role of Irisin, Adiponectin and Proinflammatory Biomarkers

et al. 2017

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“…Accumulating evidence suggests that mesenteric white adipose tissue (mWAT), composed of not only fat but also macrophages and T lymphocytes, plays an important role as the source of inflammation and releases various inflammatory factors such as cytokines and chemokines [64–68]. This mesenteric fat which is present from the onset of disease is associated with overexpression of TNF- α , leptin, and other adipokines and correlates with the severity of intestinal inflammation and tissue injury, suggesting an important role for adipose tissue in the intestinal inflammatory process in CD [55, 62, 69–71]. The intestinal luminal leptin, a cytokine produced by adipocytes, is increased in CD and can upregulate NF- κ B expression in colonic epithelial cells [58, 72–74].…”

Section: Discussionmentioning

confidence: 99%

The Role of Physical Exercise in Inflammatory Bowel Disease

Bilski

Brzozowski

Mazur-Biały

et al. 2014

BioMed Research International

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We reviewed and analyzed the relationship between physical exercise and inflammatory bowel disease (IBD) which covers a group of chronic, relapsing, and remitting intestinal disorders including Crohn's disease (CD) and ulcerative colitis. The etiology of IBD likely involves a combination of genetic predisposition and environmental risk factors. Physical training has been suggested to be protective against the onset of IBD, but there are inconsistencies in the findings of the published literature. Hypertrophy of the mesenteric white adipose tissue (mWAT) is recognized as a characteristic feature of CD, but its importance for the perpetuation of onset of this intestinal disease is unknown. Adipocytes synthesize proinflammatory and anti-inflammatory cytokines. Hypertrophy of mWAT could play a role as a barrier to the inflammatory process, but recent data suggest that deregulation of adipokine secretion is involved in the pathogenesis of CD. Adipocytokines and macrophage mediators perpetuate the intestinal inflammatory process, leading to mucosal ulcerations along the mesenteric border, a typical feature of CD. Contracting skeletal muscles release biologically active myokines, known to exert the direct anti-inflammatory effects, and inhibit the release of proinflammatory mediators from visceral fat. Further research is required to confirm these observations and establish exercise regimes for IBD patients.

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“…The impact that infliximab treatment has on mesenteric adipose tissue alterations during intestinal inflammation was not investigated properly. Therefore, the authors decided to investigate this topic further by using an experimental model of intestinal inflammation, in which some adipose tissue alterations were previously described [12,19,20]. The authors first tried to determine if infliximab (a mouse/human antibody) was able to neutralize rat TNF-a in vitro, using a biological assay that was reported by van de Loosdrecht et al in 1993 [14].…”

Section: Discussionmentioning

confidence: 99%

Infliximab modifies mesenteric adipose tissue alterations and intestinal inflammation in rats with TNBS-induced colitis

Clemente

Santos

Sturaro

et al. 2012

Scandinavian Journal of Gastroenterology

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Perinodal Adipose Tissue and Mesenteric Lymph Node Activation During Reactivated TNBS-Colitis in Rats

Cited by 20 publications

References 33 publications

Beneficial Effect of Voluntary Exercise on Experimental Colitis in Mice Fed a High-Fat Diet: The Role of Irisin, Adiponectin and Proinflammatory Biomarkers

Beneficial Effect of Voluntary Exercise on Experimental Colitis in Mice Fed a High-Fat Diet: The Role of Irisin, Adiponectin and Proinflammatory Biomarkers

The Role of Physical Exercise in Inflammatory Bowel Disease

Infliximab modifies mesenteric adipose tissue alterations and intestinal inflammation in rats with TNBS-induced colitis

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