Exposure to environmental stressors result in increased viral load and further reduction of production parameters in pigs experimentally infected with PCV2b

Patterson, Robert; Nevel, Amanda; Díaz, Adriana V.; Martineau, Henny; Demmers, T. G. M.; Browne, Christopher; Mavrommatis, Bettina; Werling, Dirk

doi:10.1016/j.vetmic.2015.03.010

Cited by 19 publications

(13 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Morbidity varies drastically, from subclinical infections and reduced growth performance to increased mortality. Host genetics, immunity, environmental stressors and secondary pathogens are all factors which can impact clinical outcome following PRRSV or PCV2 infections (Boddicker et al, 2012;Chand et al, 2012;Opriessnig and Halbur, 2012;Patterson et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Microbiome associations in pigs with the best and worst clinical outcomes following co-infection with porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2)

Niederwerder

Jaing

Thissen

et al. 2016

Veterinary Microbiology

View full text Add to dashboard Cite

On a world-wide basis, co-infections involving porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2) are common and contribute to a range of polymicrobial disease syndromes in swine. Both viruses compromise host defenses, resulting in increased susceptibility to infections by primary and secondary pathogens that can affect growth performance as well as increased morbidity and mortality. An experimental population of 95 pigs was co-infected with PRRSV and PCV2. At 70days post-infection (dpi), 20 representative pigs were selected as having the best or worst clinical outcome based on average daily gain (ADG) and the presence of clinical disease. Worst clinical outcome pigs had prolonged and greater levels of viremia as measured by qPCR. Serum, lung and fecal samples collected at 70 dpi were analyzed using a comprehensive DNA microarray technology, the Lawrence Livermore Microbial Detection Array, to detect over 8000 microbes. Bacterial species, such as Bacillus cereus, were detected at a higher rate in the serum of worst performing pigs. At the level of the fecal microbiome, the overall microbial diversity was lower in the worst clinical outcome group. The results reinforce the importance of pathogen load in determining clinical outcome and suggest an important role of microbial diversity as a contributing factor in disease.

show abstract

Section: Introductionmentioning

confidence: 99%

Microbiome associations in pigs with the best and worst clinical outcomes following co-infection with porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2)

Niederwerder

Jaing

Thissen

et al. 2016

Veterinary Microbiology

View full text Add to dashboard Cite

show abstract

“…These are often employed to achieve a systemic IgG as well as mucosal IgA response following antigen uptake by micro-fold (M) cells [5] , [6] . Vaccines administered via the oral route cause in general less stress and associated immune-suppression for the recipient [7] , both of which are risk factor for developing PCVAD [8] , [9] .…”

Section: Introductionmentioning

confidence: 99%

Oral application of freeze-dried yeast particles expressing the PCV2b Cap protein on their surface induce protection to subsequent PCV2b challenge in vivo

Patterson

Eley

Browne

et al. 2015

Vaccine

Self Cite

View full text Add to dashboard Cite

show abstract

“…Based on available information, it has been shown that several infectious cofactors and noninfectious conditions such as concurrent infection with other pathogens [103, 104], host genetic make-up [105], and management practices [106] are crucial for disease progression to PCVAD. Consequently, infections with PCV2 have been regarded as multifactorial at the instances of other underlying cofactors that exacerbate infection with the viral pathogens resulting in the clinical disease manifestations.…”

Section: Porcine Circovirus Type 2 (Pcv2)mentioning

confidence: 99%

“…[114], E. coli [115], and Metastrongylus elongatus [116]. The noninfectious cofactors include the genetic background of the pig, high stocking density, and prevailing environmental conditions such as temperature fluctuation within the pen [106]. …”

Section: Porcine Circovirus Type 2 (Pcv2)mentioning

confidence: 99%

Global Status ofPorcine circovirusType 2 and Its Associated Diseases in Sub-Saharan Africa

Afolabi

Iweriebor

Okoh

et al. 2017

Advances in Virology

View full text Add to dashboard Cite

Globally, Porcine circovirus type 2 (PCV2) is a recognized viral pathogen of great economic value in pig farming. It is the major cause of ravaging postweaning multisystemic wasting syndrome (PMWS) and many other disease syndromes generally regarded as Porcine circovirus associated diseases (PCVAD) in Europe. PCV2 infections, specifically PMWS, had impacted huge economic loss on swine production at different regions of the world. It has been studied and reported at different parts of the globe including: North and South America, Europe, Asia, Oceania, Middle East, and the Caribbean. However, till date, this virus and its associated diseases have been grossly understudied in sub-Sahara African region and the entire continent at large. Two out of forty-nine, representing just about 4% of countries that make up sub-Sahara Africa presently, have limited records on reported cases and occurrence of the viral pathogen despite the ubiquitous nature of the virus. This review presents an overview of the discovery of Porcine circovirus and its associated diseases in global pig herds and emphasizes the latest trends in PCV2 vaccines and antiviral drugs development and the information gaps that exist on the occurrence of this important viral pathogen in swine herds of sub-Saharan Africa countries. This will serve as wake-up call for immediate and relevant actions by stakeholders in the region.

show abstract

Exposure to environmental stressors result in increased viral load and further reduction of production parameters in pigs experimentally infected with PCV2b

Abstract: HighlightsEnvironmental stress increases viral load of PCV2b in serum and tissue.Environmental stress exacerbates PCV2b induced weight loss.Environmental stress and PCV2b reduce ADG and impact negatively on FCR.

Cited by 19 publications

References 32 publications

Microbiome associations in pigs with the best and worst clinical outcomes following co-infection with porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2)

Microbiome associations in pigs with the best and worst clinical outcomes following co-infection with porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus type 2 (PCV2)

Oral application of freeze-dried yeast particles expressing the PCV2b Cap protein on their surface induce protection to subsequent PCV2b challenge in vivo

Global Status ofPorcine circovirusType 2 and Its Associated Diseases in Sub-Saharan Africa

Contact Info

Product

Resources

About