Exposure to elevated per- and polyfluoroalkyl substances in early pregnancy is related to increased risk of gestational diabetes mellitus: A nested case-control study in Shanghai, China

Xu, Huangfang; Zhou, Qiongjie; Zhang, Jiming; Chen, Xinning; Zhao, Huanqiang; Lu, Huiqing; Ma, Bo; Wang, Zheng; Wu, Chunhua; Ying, Chunmei; Xiong, Yan; Zhou, Zhijun; Li, Xiaotian

doi:10.1016/j.envint.2020.105952

Cited by 49 publications

(28 citation statements)

References 46 publications

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“…Among pregnant women, gestational diabetes mellitus (GDM) and PFAS exposure has so far revealed inconsistent and component specific differences [ 67 , 68 , 69 ]. In one study, PFOS, PFOA, PFHxS, PFNA, 2-(N-ethyl-perfluorooctane sulfonamide) acetate, N-ethyl perfluorooctanesulfonamidoacetate (EtFOSAA), N-methyl perfluorooctanesulfon-aminodoacetate (MeFOSAA), perfluorodecanoate, and perfluorooctanesulfonamidoacetate (FOSAA) exposure showed no association with glucose tolerance and PFAS exposure [ 68 ].…”

Section: Resultsmentioning

confidence: 99%

Metabolic Syndrome and Endocrine Disrupting Chemicals: An Overview of Exposure and Health Effects

Haverinen

Fernández

Mustieles

et al. 2021

IJERPH

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Increasing prevalence of metabolic syndrome (MetS) is causing a significant health burden among the European population. Current knowledge supports the notion that endocrine-disrupting chemicals (EDCs) interfere with human metabolism and hormonal balance, contributing to the conventionally recognized lifestyle-related MetS risk factors. This review aims to identify epidemiological studies focusing on the association between MetS or its individual components (e.g., obesity, insulin resistance, diabetes, dyslipidemia and hypertension) and eight HBM4EU priority substances (bisphenol A (BPA), per- and polyfluoroalkyl substances (PFASs), phthalates, polycyclic aromatic hydrocarbons (PAHs), pesticides and heavy metals (cadmium, arsenic and mercury)). Thus far, human biomonitoring (HBM) studies have presented evidence supporting the role of EDC exposures on the development of individual MetS components. The strength of the association varies between the components and EDCs. Current evidence on metabolic disturbances and EDCs is still limited and heterogeneous, and mainly represent studies from North America and Asia, highlighting the need for well-conducted and harmonized HBM programmes among the European population. Rigorous and ongoing HBM in combination with health monitoring can help to identify the most concerning EDC exposures, to guide future risk assessment and policy actions.

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Section: Resultsmentioning

confidence: 99%

Metabolic Syndrome and Endocrine Disrupting Chemicals: An Overview of Exposure and Health Effects

Haverinen

Fernández

Mustieles

et al. 2021

IJERPH

View full text Add to dashboard Cite

show abstract

“…Liu et al investigated the short-chained perfluorocarboxylates (PFBA, PFPeA, PFHxA, and PFHpA) and observed increased odds for GDM across increasing tertiles (OR: 1.82 and 3.01 in the 2nd and 3rd tertiles compared to the first; p = 0.011) [ 55 ]. Another study by Xu et al found a very high adjusted odds ratio for the association between GDM and PFDoA (OR = 13.00; CI: 4.74–24.59), and an odds ratio of 2.02 for PFBS ( p < 0.01) [ 56 ]. Preston et al also found a positive association between PFOS and glucose levels, but the authors observed a non-monotonic response for PFOSA and glucose levels [ 57 ].…”

Section: Resultsmentioning

confidence: 99%

Associations between Exposures to Perfluoroalkyl Substances and Diabetes, Hyperglycemia, or Insulin Resistance: A Scoping Review

Margolis

Sant

2021

JoX

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Per- and polyfluoroalkyl substances (PFASs) are persistent environmental pollutants that are commonly found in the human body due to exposures via drinking water, surfactants used in consumer materials, and aqueous film-forming foams (AFFFs). PFAS exposure has been linked to adverse health effects such as low infant birth weights, cancer, and endocrine disruption, though increasingly studies have demonstrated that they may perturb metabolic processes and contribute to dysfunction. This scoping review summarizes the chemistry of PFAS exposure and the epidemiologic evidence for associations between exposure to per- and polyfluoroalkyl substances and the development of diabetes, hyperglycemia, and/or insulin resistance. We identified 11 studies on gestational diabetes mellitus, 3 studies on type 1 diabetes, 7 studies on type 2 diabetes, 6 studies on prediabetes or unspecified diabetes, and 15 studies on insulin resistance or glucose tolerance using the SCOPUS and PubMed databases. Approximately 24 reported positive associations, 9 negative associations, 2 non-linear associations, and 2 inverse associations, and 8 reported no associations found between PFAS and all diabetes search terms. Cumulatively, these data indicate the need for further studies to better assess these associations between PFAS exposure and diabetes.

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“…Out of the 11 epidemiological studies that reported on the association of PFAS and GDM [ 56 – 66 ], four (44%) demonstrated a positive association, differing by PFAS compound (Table 1 , Supplemental Table 3 ) [ 56 , 59 , 62 , 63 ]. Overall, higher PFAS levels were associated with higher risk of GDM development.…”

Section: Pfas Exposure and Risk Of Gestational Diabetes Mellitus (Gdm) Development And Candidate Biomarkers: Evidence In The Literaturementioning

confidence: 99%

A pathway level analysis of PFAS exposure and risk of gestational diabetes mellitus

et al. 2021

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Per- and polyfluoroalkyl substances (PFAS) have been found to be associated with gestational diabetes mellitus (GDM) development, a maternal health disorder in pregnancy with negative effects that can extend beyond pregnancy. Studies that report on this association are difficult to summarize due to weak associations and wide confidence intervals. One way to advance this field is to sharpen the biologic theory on a causal pathway behind this association, and to measure it directly by way of molecular biomarkers. The aim of this review is to summarize the literature that supports a novel pathway between PFAS exposure and GDM development. Epidemiological studies demonstrate a clear association of biomarkers of thyroid hormones and glucose metabolism with GDM development. We report biologic plausibility and epidemiologic evidence that PFAS dysregulation of maternal thyroid hormones and thyrotropin (TSH) may disrupt glucose homeostasis, increasing the risk of GDM. Overall, epidemiological studies demonstrate that PFAS were positively associated with TSH and negatively with triiodothyronine (T3) and thyroxine (T4). PFAS were generally positively associated with glucose and insulin levels in pregnancy. We propose dysregulation of thyroid function and glucose metabolism may be a critical and missing component in the accurate estimation of PFAS on the risk of GDM.

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Exposure to elevated per- and polyfluoroalkyl substances in early pregnancy is related to increased risk of gestational diabetes mellitus: A nested case-control study in Shanghai, China

Cited by 49 publications

References 46 publications

Metabolic Syndrome and Endocrine Disrupting Chemicals: An Overview of Exposure and Health Effects

Metabolic Syndrome and Endocrine Disrupting Chemicals: An Overview of Exposure and Health Effects

Associations between Exposures to Perfluoroalkyl Substances and Diabetes, Hyperglycemia, or Insulin Resistance: A Scoping Review

A pathway level analysis of PFAS exposure and risk of gestational diabetes mellitus

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