Exposure to early life adversity alters the future behavioral response to a stressful challenge in BALB/C mice

Nisar, Safia; Farooq, Rai Khalid; Nazir, Sadia; Alamoudi, Widyan; Alhibshi, Amani

doi:10.1016/j.physbeh.2019.112622

Cited by 4 publications

(2 citation statements)

References 42 publications

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“…Nanobody (VHH) generation [191] Mice Wild derived strain: Cancer therapy, Drug development, Hybridoma technology, Toxicological evaluation, DNA vaccines, Nanotechnology, Inflammation, Chronic stress, Behavioral studies and depression [192], [193], [194] Mus musculus [62,195], [196] Inbred strains: [197], [198] BALB/c, C57BL/6 [199], [200] Nematode Caenorhabditis elegans Drug development screening, Toxicological evaluation [201], [202] Non-human primates…”

Section: Lama Glamamentioning

confidence: 99%

Research Models in Biomedical Sciences: Advantages and Limitations

Mb¹

2020

OAJBS

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Research models are routinely used in the biomedical field when we are talking about assays. All these models have advantages and limitations and should be chosen carefully, to avoid, mainly, mistakes in ethical practices. However, it is a great challenge for researchers picking and classifying their experimental models due to the lack of clear literature definition or guidelines. Here, we pioneer describe the overall definition of the main research models and give a gamut of examples from the biomedical field. This review also provides recommendations for aligning experimental practices to meet the necessity of assessing an international research model classification.

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Section: Lama Glamamentioning

confidence: 99%

Research Models in Biomedical Sciences: Advantages and Limitations

Mb¹

2020

OAJBS

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“…Conversely, pharmacological or optical silencing of this IL pathway in fear extinction learning results in increased freezing behavior and reduced extinction rates (Adhikari et al, 2015;Gutman et al, 2017;Laurent and Westbrook, 2009). However, ELS appears to alter these normal fear and anxiety-related processes, disrupting conditioned fear as well as decreasing exploration of open arms in an elevated plus maze (Nisar et al, 2019;Oldham Green et al, 2021;Toda et al, 2014). While recent work has provided tremendous ex vivo insight into the genetic, epigenetic, and molecular bases for these differences particularly in the PFC (Oldham Green et al, 2021;Torres-Berrío et al, 2019), surprisingly little is known about how mature in vivo neurons in ELS-experienced animals encode information about threat and safety during behavior.…”

Section: Introductionmentioning

confidence: 99%

Elevated fear responses to threatening cues in rats with early life stress is associated with greater excitability and loss of gamma oscillations in ventral-medial prefrontal cortex

Bercum

Gomez

Saddoris

2021

Preprint

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Stress experienced early in development can have profound influences on developmental trajectories and ultimately behaviors in adulthood. Potent stressors during brain maturation can profoundly disrupt prefrontal cortical areas in particular, which can set the stage for prefrontal-dependent alterations in fear regulation and risk of drug abuse in adulthood. Despite these observations, few studies have investigated in vivo signaling in prefrontal signals in animals with a history of early life stress (ELS). Here, rats with ELS experience on PND3-5 were then tested on a conditioned suppression paradigm during adulthood. During conditioned suppression, electrophysiological recordings were made in the ventral medial prefrontal cortex (vmPFC) during presentations of a fear-associated cues that resolved both single-unit activity and local field potentials (LFPs). Relative to unstressed controls, ELS-experienced rats showed greater fear-related suppression of lever pressing. During presentations of the fear-associated cue (CS+), neurons in the vmPFC of ELS animals showed a significant increase in the probability of excitatory encoding relative to controls, and excitatory phasic responses in the ELS animals were reliably of higher magnitude than Controls. In contrast, vmPFC neurons in ELS subjects better discriminated between the shock-associated CS+ and the neutral ("safe") CS- cue than Controls. LFPs recorded in the same locations revealed that high gamma band (65-95 Hz) oscillations were strongly potentiated in Controls during presentation of the fear-associated CS+ cue, but this potentiation was abolished in ELS subjects. Notably, no other LFP spectra differed between ELS and Controls for either the CS+ or CS-. Collectively, these data suggest that ELS experience alters the neurobehavioral functions of PFC in adulthood that are critical for processing fear regulation. As such, these alterations may also provide insight into to increased susceptibility to other PFC-dependent processes such as risk-based choice, motivation, and regulation of drug use and relapse in ELS populations.

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