Elevated fear responses to threatening cues in rats with early life stress is associated with greater excitability and loss of gamma oscillations in ventral-medial prefrontal cortex

Bercum, Florencia M.; Gomez, Maria Jose Navarro; Saddoris, Michael P.

doi:10.1016/j.nlm.2021.107541

Cited by 12 publications

(5 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results are congruent with disturbed developmental trajectories of limbic regions like BLA, mPFC, and hippocampus, and potentially including dopaminergic function as they related to behavior in ambiguous contexts. These data also extend previous work from our laboratory showing that early life adversity disturbs fear-related learning in adulthood (Bercum et al, 2021, Bercum et al, 2023).…”

Section: Discussionsupporting

confidence: 90%

“…Training occurred in four identical fear conditioning chambers (43 × 43 × 53 cm; Med Associates, St. Albans, VT) wherein inserts and other contextual stimuli were used to generate easily discriminable spaces. By default, these chambers were equipped with aluminum side walls, a transparent Plexiglas door and ceiling, a grid floor comprised of stainless steel rods placed 2 mm apart, and a removable tray below the floor grid (Bercum et al, 2021(Bercum et al, , 2023. In addition, the boxes could be illuminated from above using near-infrared light or a centrally located LED house light and were insulated from external stimuli via a sound-attenuating cabinet with a digital camera mounted on the interior of each cabinet's door.…”

Section: Adulthood: Fear Acquisition Extinction and Renewalmentioning

confidence: 99%

See 1 more Smart Citation

Voluntary alcohol consumption during distinct phases of adolescence differentially alters adult fear acquisition, extinction and renewal in male and female rats

Grizzell,

Vanbaelinghem,

Westerman

et al. 2023

Preprint

View full text Add to dashboard Cite

Alcohol use during adolescence coincides with elevated risks of stress-related impairment in adults, particularly via disrupted developmental trajectories of vulnerable corticolimbic and mesolimbic systems involved in fear processing. Prior work has investigated the impact of binge-like alcohol consumption on adult fear and stress, but less is known about whether voluntarily consumed alcohol imparts differential effects based on adolescence phases and biological sex. Here, adolescent male and female Long Evans rats were granted daily access to alcohol (15%) during either early (Early-EtOH; P25-45) or late adolescence (Late-EtOH; P45-55) using a modified drinking-in-the-dark design. Upon adulthood (P75-80), rats were exposed to a three-context (ABC) fear renewal procedure. We found that male and female Early-EtOH rats showed faster acquisition of fear but less freezing during early phases of extinction and throughout fear renewal. In the extinction period specifically, Early-EtOH rats showed normal levels of freezing in the presence of fear-associated cues, but abnormally low freezing immediately after cue offset, suggesting a key disruption in contextual processing and/or novelty seeking brought by early adolescent binge consumption. While the effects of alcohol were most pronounced in the Early-EtOH rats (particularly in females), Late-EtOH rats displayed some changes in fear behavior including slower fear acquisition, faster extinction, and reduced renewal compared with controls, but primarily in males. Our results suggest that early adolescence in males and females and, to a lesser extent, late adolescence in males is a particularly vulnerable period wherein alcohol use can promote stress-related dysfunction in adulthood. Furthermore, our results provide multiple bases for future research focused on developmental correlates of alcohol mediated disruption in the brain.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Adulthood: Fear Acquisition Extinction and Renewalmentioning

confidence: 99%

Voluntary alcohol consumption during distinct phases of adolescence differentially alters adult fear acquisition, extinction and renewal in male and female rats

Grizzell,

Vanbaelinghem,

Westerman

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…4) that may have represented aberrant stress-induced hyperactivity. Both have been associated with levels of neural activity and function (Fitzgerald & Watson, 2018; Wang et al, 2018), as well as stress-responses (Bercum et al, 2021; Tran et al, 2007), however, their functional significance is unclear.…”

Section: Discussionmentioning

confidence: 99%

Immediate and Long-Term Electrophysiological Biomarkers of Antidepressant Behavioral Effects After Subanesthetic Ketamine and Medial Prefrontal Cortex Deep Brain Stimulation Treatment

Bergosh,

Medvidovic,

Zepeda

et al. 2023

Preprint

View full text Add to dashboard Cite

Ketamine and medial prefrontal cortex (mPFC) deep brain stimulation (DBS) are emerging depression treatments, however their mechanisms and efficacy biomarkers have not been established. This study investigates immediate and long-term mPFC electrophysiological correlates of their antidepressant effects, and explores the effects of combinatorial treatment. Local field potential electrodes were implanted into the mPFC of male Sprague Dawley rats, then corticosterone was administered for 21 days, except in the control group (n = 8). In the last week of depression induction, the remaining groups received mPFC DBS (n = 8), ketamine (n = 9), both (n = 9), or neither (n = 8). All groups then performed a behavioral assay. We found that DBS treatment immediately suppressed relative low gamma power and improved cognition in the long-term, which correlated with rescued apathy-like behavior in the Groom Test (GT). In contrast, ketamine treatment suppressed sample entropy in the long-term, which correlated with its immediate decrease in sample entropy as well as rescued GT behavior. In the combinatorial group these changes were inhibited, which correlated with a failure to fully rescue GT behavior. Despair-like behavior in the Forced Swim Test was rescued by all three treatments, which correlated with increased relative high frequency oscillation (HFO) power immediately after ketamine and combinatorial treatment. Our findings support the utility of low gamma and HFO power, sample entropy, and cognitive tests in the search for mechanisms and biomarkers of depression and novel treatments.

show abstract

“…For example, a history of drug use alters learning and valued based decision-making [45][46][47] but also distinct deficits in learning and decision-making are linked to increased susceptibility to drug seeking or escalation of drug use [7,48]. Critically, a history of psychostimulants [21,23,49,50], opioids [51], ethanol [52], or stress [53][54][55][56] alters frontal neural activity and disrupt learning and decision-making. A rodent model of obsessivecompulsive disorder shows elevated PrL neural activity and impairments in reversal learning [57].…”

Section: Discussionmentioning

confidence: 99%

Prelimbic cortex neural encoding dynamically tracks expected outcome value

Niedringhaus¹,

West²

2022

Physiology & Behavior

View full text Add to dashboard Cite

Elevated fear responses to threatening cues in rats with early life stress is associated with greater excitability and loss of gamma oscillations in ventral-medial prefrontal cortex

Cited by 12 publications

References 66 publications

Voluntary alcohol consumption during distinct phases of adolescence differentially alters adult fear acquisition, extinction and renewal in male and female rats

Voluntary alcohol consumption during distinct phases of adolescence differentially alters adult fear acquisition, extinction and renewal in male and female rats

Immediate and Long-Term Electrophysiological Biomarkers of Antidepressant Behavioral Effects After Subanesthetic Ketamine and Medial Prefrontal Cortex Deep Brain Stimulation Treatment

Prelimbic cortex neural encoding dynamically tracks expected outcome value

Contact Info

Product

Resources

About