Exposure to dogs but not cats is associated to a decrease in the prevalence in atopic dermatitis amongst school-children

Bedolla-Barajas, Martín; Morales-Romero, Jaime; Bedolla-Pulido, Tonantzin Isis; Bedolla-Pulido, Tonatiuh Ramsés; Meza-López, Carlos; Pulido-Guillén, Norma Angélica

doi:10.1016/j.aller.2017.09.032

Cited by 6 publications

(6 citation statements)

References 23 publications

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“…Table 1 summarizes the studies included in this review [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ]. [ Table 1 ].…”

Section: Resultsmentioning

confidence: 99%

“…In our review, all the articles included explored the association between prenatal, natal, and/or infancy (1–2 years of life) exposure to cat and dog hair and the development of allergy and/or asthma in preschool and/or school-aged children [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ]. Eight articles [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 36 ] investigated these outcomes in preschoolers.…”

Section: Resultsmentioning

confidence: 99%

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The Primary Prevention of Atopy: Does Early Exposure to Cats and Dogs Prevent the Development of Allergy and Asthma in Children? A Comprehensive Analysis of the Literature

Indolfi,

D’Addio,

Bencivenga

et al. 2023

Life

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The current literature shows mixed results relating to the significance of environmental exposure, such as owning a pet, and the development of atopy in children. Our review aimed to collect the most recent evidence on the association between early-life cat and dog ownership and the development of allergy and asthma. A comprehensive literature review was performed using PubMed and Scopus. The search included the main keywords of our PICO: (((early exposure) AND (children) AND (allergy)) OR (asthma)) AND (dog) OR (cat). Randomized controlled trials (RCTs), case–control studies, clinical trials, meta-analyses, and systematic reviews of children within the last five years (2018–2023) were searched and included. During the search process, 52 articles from PubMed and 43 from Scopus were found. A total of 17 articles were deemed to be suitable and included. Fairly consistent results regarding early exposure to pets, in particular dogs, and the prevention of food allergies have been described. Furthermore, there seems to be a protective effect against allergy and asthma in relation to the number of pets owned. The likelihood of a child developing allergy and asthma seems to be influenced by various factors, including the child’s genetic background and early exposure to different environmental factors, including allergens that may interact with the gut microbiota and immune system.

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“…Table 1 summarizes the studies included in this review [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ]. [ Table 1 ].…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The Primary Prevention of Atopy: Does Early Exposure to Cats and Dogs Prevent the Development of Allergy and Asthma in Children? A Comprehensive Analysis of the Literature

Indolfi,

D’Addio,

Bencivenga

et al. 2023

Life

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“…With regard to pet dander allergens and AD, it has been previously observed that exposure to dogs, but not cats, may decrease the risk of developing AD . However, a cross‐sectional study of AD cases and controls from Hungary found that the odds of having AD were significantly higher in children that had indoor‐kept pets .…”

Section: Discussionmentioning

confidence: 99%

Is there an association between indoor allergens and the severity of atopic dermatitis?

et al. 2018

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Background Atopic dermatitis (AD) is a multifactorial inflammatory skin disease with frequent hypersensitivity to allergens. However, the role of exposure to indoor allergens on AD severity is unclear.Methods Children aged 0-17 years with active AD from central Chile were recruited; disease severity was evaluated with SCORAD and POEM scores. A home environment survey was applied to parents. Bedroom dust samples were collected for all subjects and analyzed by multiplex assay to quantify dust mite (Der p1, Der f1), dog (Can f1), cat (Fel d1), and alternaria alternata (Alt a1) allergens.Results Twenty-five children aged 3.9 AE 3.8 years were included. Fifty-two percent were female. Mean SCORAD was 29 AE 14 (range 11-61), and mean POEM was 10.7 AE 6.2.No direct association was found between tobacco exposure, pet ownership, aerosol use, visible dust, or home carpets/rugs with SCORAD (all P > 0.05). Dust samples from all homes had Can f1 and Fel d1 allergens, regardless of pet ownership. Homes that had indoor dogs or cats had significantly higher amounts of these allergens (P < 0.001). Forty percent of homes had dust mite allergens, and none had alternaria alternata. Children with AD living in homes with elevated dust mite and animal dander allergen concentrations had higher SCORAD than those from homes with low allergen concentrations (40 AE 13 vs.26 AE 13, P = 0.025). ConclusionsHigh concentrations of indoor allergens may influence AD severity in children. Further studies assessing indoor allergens and allergen sensitization are warranted to fully evaluate the role of indoor allergens on AD.

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“…Cat and dog allergens are commonly found in public places and around 90% of homes in the United States have measurable levels of these allergens whether the home has ever had a furred pet living in it or not 17 . The studies exploring the association between pets and atopic diseases have been contradictory so far 18,19 . Though, systematic reviews have reported reductions in the risk of atopic diseases among children with close contact with animals (farm animals or indoor pets) during infancy 20–22 .…”

Section: Discussionmentioning

confidence: 99%

“… 17 The studies exploring the association between pets and atopic diseases have been contradictory so far. 18 , 19 Though, systematic reviews have reported reductions in the risk of atopic diseases among children with close contact with animals (farm animals or indoor pets) during infancy. 20 , 21 , 22 However, regarding AD some studies have found a protective association of pets, 23 and others studies with adjustment for avoidance behavior have not found this association.…”

Section: Discussionmentioning

confidence: 99%

Associations between maternal and environmental exposures on atopic disease in the offspring of mothers with asthma

Ali

Jemec

Ulrik

2021

Immunity Inflam & Disease

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Background and Objective Available data on the impact of perinatal and environmental factors on atopic diseases in the offspring are sparse and conflicting. We, therefore, investigated the impact of these factors on the risk of atopic diseases in the offspring of women with asthma. Methods Pregnant women referred to give birth at Copenhagen University Hospital‐Hvidovre, Denmark, have since 2007 been invited to participate in the Management of Asthma during Pregnancy program. Women with diagnosed asthma, currently prescribed asthma medication, first visit to the respiratory out‐patient clinic within the first 18 weeks of pregnancy that completed an online questionnaire about atopic diseases in their child were included in the current study. Results Five hundred and seventy‐one pregnancies were included. Among the off‐spring, 113 children (21%) had doctor‐diagnosed asthma, 178 (31%) atopic dermatitis (AD), and 55 (32%) both AD and doctor‐diagnosed asthma. AD in the offspring was associated with having a dog at home (odds ratio [OR], 2.56; 95% confidence interval [CI], [1.40–4.67], p = .002), whereas having a cat at home was associated with a higher risk of asthma in the offspring (OR, 2.16; 95% CI, [1.14–4.11], p = .02). The associations remained significant after adjusting for maternal age, smoking status, allergy, treatment with inhaled corticosteroids, forced expiratory volume in 1 s less than 80% predicted, uncontrolled asthma, and history of pre‐pregnancy asthma exacerbations. No association was found between gestational weight gain (GWG) in first trimester and total GWG and atopic disease in the offspring. Conclusion Having pets at home is associated with AD and asthma in the offspring of mothers with asthma.

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Exposure to dogs but not cats is associated to a decrease in the prevalence in atopic dermatitis amongst school-children

Abstract: Our findings suggest that exposure to dogs, whether they be indoor or outdoor pets, is associated to a decreased prevalence in atopic dermatitis.

Cited by 6 publications

References 23 publications

The Primary Prevention of Atopy: Does Early Exposure to Cats and Dogs Prevent the Development of Allergy and Asthma in Children? A Comprehensive Analysis of the Literature

The Primary Prevention of Atopy: Does Early Exposure to Cats and Dogs Prevent the Development of Allergy and Asthma in Children? A Comprehensive Analysis of the Literature

Is there an association between indoor allergens and the severity of atopic dermatitis?

Associations between maternal and environmental exposures on atopic disease in the offspring of mothers with asthma

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