Exposure to Diesel Motor Exhaust and Lung Cancer Risk in a Pooled Analysis from Case-Control Studies in Europe and Canada

Olsson, Ann; Gustavsson, Per; Kromhout, Hans; Peters, Susan; Vermeulen, Roel; Brüske, Irene; Pesch, Beate; Siemiatycki, Jack; Pintos, Javier; Brüning, Thomas; Cassidy, Adrian; Wichmann, Heinz Erich; Consonni, Dario; Landi, Maria Teresa; Caporaso, Neil E.; Plato, Nils; Merletti, Franco; Mirabelli, Dario; Richiardi, Lorenzo; Jöckel, Karl Heinz; Ahrens, Wolfgang; Pohlabeln, Hermann; Lissowska, Jolanta; Szeszenia-Da̧browska, Neonila; Заридзе, Давид; Stücker, Isabelle; Benhamou, Simone; Bencko, Vladimír; Foretová, Lenka; Janout, Vladimí­r; Rudnai, Péter; Fabiánovà, Eleonóra; Dumitru, Rodica Stanescu; Groß, Isabelle; Kendzia, Benjamin; Forastiére, Francesco; Bueno‐de‐Mesquita, Bas; Brennan, Paul; Boffetta, Paolo; Straif, Kurt

doi:10.1164/rccm.201006-0940oc

Cited by 151 publications

(157 citation statements)

References 110 publications

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“…Benzene and formaldehyde are examples of VOCs classified as human carcinogens [5]. Epidemiological studies have shown an increased risk for lung and gastric cancers in subjects exposed at the workplace to high concentrations of diesel exhaust [6][7][8]. Bio-monitoring the effect of exposure to genotoxic substances in the workplace is essential for the development of strategies to improve occupational health and safety conditions [9].…”

Section: Introductionmentioning

confidence: 99%

Exposure of thermoelectric power-plant workers to volatile organic compounds from fuel oil: Genotoxic and cytotoxic effects in buccal epithelial cells

Garcia

Linhares

Amaral

et al. 2012

Mutation Research/Genetic Toxicology and Environmental Mutagene

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a b s t r a c tThermoelectric power-plant workers are constantly exposed to high levels of potentially genotoxic gaseous substances, such as volatile organic compounds (VOCs) from the combustion of fuel oil or the processing of naphtha. The aim of the present study was to estimate the association between such occupational exposure and the frequency of micronucleated cells and cells with other nuclear anomalies.Buccal epithelial cells were collected from a total of 44 power-plant workers (exposed group) and 47 administrative workers (non-exposed group), and examined for the frequency of micronucleated cells (MNC) and of cells with other nuclear anomalies (ONA: pyknosis, karyolysis, and karyorrhexis) by means of the micronucleus assay. The frequencies of MNC and ONA per 1000 cells in the exposed group (1.8‰ and 82.4‰, respectively) were significantly higher than in the non-exposed group (0.2‰ and 58.3‰, respectively). The exposed group had a twelve-fold increase in risk for formation of MNC compared with non-exposed individuals (RR = 12.1; 95% CI, 5.0-29.2; P < 0.001). The confounding factors analyzed (age, smoking status, alcohol consumption, and mouthwash use) did not show any significant association with the frequency of MNC or ONA.The findings of this study show that workers from power plants exposed to VOCs have a significantly elevated risk for DNA damage. Therefore, bio-monitoring of DNA damage is recommended for this group of workers.

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Section: Introductionmentioning

confidence: 99%

Exposure of thermoelectric power-plant workers to volatile organic compounds from fuel oil: Genotoxic and cytotoxic effects in buccal epithelial cells

Garcia

Linhares

Amaral

et al. 2012

Mutation Research/Genetic Toxicology and Environmental Mutagene

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“…We used the SYNERGY database of pooled casecontrol studies on lung cancer (19)(20)(21)(22)(23)(24) to estimate smoking-adjusted risks for lung cancer among coal miners, ore miners, and quarrymen (http://synergy.iarc.fr). The strengths of the SYNERGY database are detailed information on smoking behavior including the possibility to estimate pack-years of smoking as well as the full occupational history, enabling adjustment for occupational exposure to lung carcinogens from other at-risk jobs.…”

mentioning

confidence: 99%

Lung cancer among coal miners, ore miners and quarrymen: smoking-adjusted risk estimates from the synergy pooled analysis of case–control studies

Taeger

Pesch

Kendzia

et al. 2015

Scand J Work Environ Health

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“…Further, a consistent association between occupational exposure to diesel motor exhaust and increased risk of lung cancer was found [53]. Against, occupational polycyclic aromatic hydrocarbons exposure does not appear to substantially contribute to the burden of lung cancer in Central and Eastern Europe [54].…”

Section: Occupational Exposure To Environmental Chemicals and Carcinomentioning

confidence: 86%

Endocrine Disruptors and Carcinogenesis

Karoutsou¹,

Karoutsos²,

Karoutsos³

2017

Arch Can Res

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Environmental chemicals that at certain doses interfere with the endocrine system are called endocrine disruptors; the disruption of homeostasis induced is including birth defects, feminizing effects and cancerous tumors. The critical window of development for most organisms is the in utero period where substantial damage to a developing fetus takes place after exposure to these chemicals; further, the risk of cancer development increases after environmental or occupational exposure later in life. In this review, epidemiological data are quoted regarding the increased cancer risk after the exposure to endocrine disruptors, while a current quantitation method of the chemical carcinogenesis evolving is also provided.

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Exposure to Diesel Motor Exhaust and Lung Cancer Risk in a Pooled Analysis from Case-Control Studies in Europe and Canada

Abstract: Our results show a consistent association between occupational exposure to diesel motor exhaust and increased risk of lung cancer. This association is unlikely explained by bias or confounding, which we addressed by adjusted models and subgroup analyses.

Cited by 151 publications

References 110 publications

Exposure of thermoelectric power-plant workers to volatile organic compounds from fuel oil: Genotoxic and cytotoxic effects in buccal epithelial cells

Exposure of thermoelectric power-plant workers to volatile organic compounds from fuel oil: Genotoxic and cytotoxic effects in buccal epithelial cells

Lung cancer among coal miners, ore miners and quarrymen: smoking-adjusted risk estimates from the synergy pooled analysis of case–control studies

Endocrine Disruptors and Carcinogenesis

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