Lung cancer among coal miners, ore miners and quarrymen: smoking-adjusted risk estimates from the
                    synergy pooled analysis of case–control studies

Taeger, Dirk; Pesch, Beate; Kendzia, Benjamin; Behrens, Thomas; Jöckel, Karl Heinz; Dahmann, D.; Siemiatycki, Jack; Kromhout, Hans; Vermeulen, Roel; Peters, Susan; Olsson, Ann; Brüske, Irene; Wichmann, Heinz Erich; Stücker, Isabelle; Guida, Florence; Tardón, Adonina; Merletti, Franco; Mirabelli, Dario; Richiardi, Lorenzo; Pohlabeln, Hermann; Ahrens, Wolfgang; Landi, Maria Teresa; Caporaso, Neil E.; Pesatori, Angela Cecilia; Mukeriya, Anush; Szeszenia-Da̧browska, Neonila; Lissowska, Jolanta; Gustavsson, Per; Field, John K.; Marcus, Michael W.; Fabiánovà, Eleonóra; Mannetje, Andrea ’t; Pearce, Neil; Rudnai, Péter; Bencko, Vladimír; Janout, Vladimí­r; Dumitru, Rodica Stanescu; Foretová, Lenka; Forastiére, Francesco; McLaughlin, John; Demers, Paul A.; Bueno‐de‐Mesquita, Bas; Schüz, Joachim; Straif, Kurt; Brüning, Thomas

doi:10.5271/sjweh.3513

Cited by 33 publications

(18 citation statements)

References 27 publications

(41 reference statements)

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“…A study on lung cancer incidence among miners found a higher lung cancer risk among men employed in mining, especially ore miners and quarrymen. The association remained significant after controlling for smoking and occupational exposure from working in other at-risk occupations [ 44 ]. To incorporate possible occupational exposure, the analysis was repeated for a subset of the male study population including individual occupation in high-risk industries in 1981.…”

Section: Discussionmentioning

confidence: 99%

Regional Inequalities in Lung Cancer Mortality in Belgium at the Beginning of the 21st Century: The Contribution of Individual and Area-Level Socioeconomic Status and Industrial Exposure

et al. 2016

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Being a highly industrialized country with one of the highest male lung cancer mortality rates in Europe, Belgium is an interesting study area for lung cancer research. This study investigates geographical patterns in lung cancer mortality in Belgium. More specifically it probes into the contribution of individual as well as area-level characteristics to (sub-district patterns in) lung cancer mortality. Data from the 2001 census linked to register data from 2001–2011 are used, selecting all Belgian inhabitants aged 65+ at time of the census. Individual characteristics include education, housing status and home ownership. Urbanicity, unemployment rate, the percentage employed in mining and the percentage employed in other high-risk industries are included as sub-district characteristics. Regional variation in lung cancer mortality at sub-district level is estimated using directly age-standardized mortality rates. The association between lung cancer mortality and individual and area characteristics, and their impact on the variation of sub-district level is estimated using multilevel Poisson models. Significant sub-district variations in lung cancer mortality are observed. Individual characteristics explain a small share of this variation, while a large share is explained by sub-district characteristics. Individuals with a low socioeconomic status experience a higher lung cancer mortality risk. Among women, an association with lung cancer mortality is found for the sub-district characteristics urbanicity and unemployment rate, while for men lung cancer mortality was associated with the percentage employed in mining. Not just individual characteristics, but also area characteristics are thus important determinants of (regional differences in) lung cancer mortality.

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Section: Discussionmentioning

confidence: 99%

Regional Inequalities in Lung Cancer Mortality in Belgium at the Beginning of the 21st Century: The Contribution of Individual and Area-Level Socioeconomic Status and Industrial Exposure

et al. 2016

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“…As such, there is strong evidence linking excess lung cancer risk to employment in occupations including construction6; quarries, sand pits and mining7; transportation8 9; painting10 and welding,11 even after adjusting for smoking.…”

Section: Introductionmentioning

confidence: 99%

Examining lung cancer risks across different industries and occupations in Ontario, Canada: the establishment of the Occupational Disease Surveillance System

et al. 2018

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“…Some Experts asserted the epidemiology data strongly supported the rat was unique but, as yet, was not conclusive. One Expert cited a recent study on coal dust exposed workers as supporting lung cancer occurrence in coal workers exposed to high dust levels (Taeger et al 2015). Several Experts strongly disagreed with the quality and interpretation of this study, citing several recent studies that found no association between coal dust exposure and lung cancer (Attfield and Kuempel 2008;Miller and MacCalman 2010;Stayner and Graber 2011;Morfeld 2013;Morfeld et al 2015).…”

Section: Is the Rat Lung Cancer Response To Pslts Unique From Other Rmentioning

confidence: 95%

“…A majority of workshop experts (9 of 15) asserted that studies in coal miners do not provide proof for elevated lung cancer risks. However, one expert was of the opinion, based on the study of Taeger et al (2015), that elevated lung cancer risk in coal miners cannot be ruled out. As stated previously, several experts strongly disagreed with the quality and interpretation of the Taeger et al (2015) study and cited several studies in support of their position including: IARC (1997), Attfield and Kuempel (2008), Miller and MacCalman (2010), Stayner and Graber (2011), Morfeld (2013), and Morfeld et al (2015).…”

Section: Is the Rat Lung Cancer Response To Pslts Unique From Other Rmentioning

confidence: 99%

Expert workshop on the hazards and risks of poorly soluble low toxicity particles

Driscoll

Borm

2020

Inhalation Toxicology

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Lung particle overload' refers to the impaired lung particle clearance and increased particle retention occurring with high lung doses of poorly soluble low toxicity (PSLT) particles. In rats, lung particle overload is associated with inflammation, epithelial hyperplasia, and, in extreme cases, lung cancer. While the human relevance of rat lung tumors occurring under overload has been questioned, recent regulatory decisions have considered these outcomes evidence of possible human hazard. To better understand the state-of-the-science on PSLT toxicology, an Expert Workshop was held to document agreements and differences amongst a panel of highly experienced scientists and regulators. Key outcomes included: a functional definition of PSLTs; agreement the rat is a sensitive model for PSLT inhalation toxicology; identifying lung inflammation as a critical endpoint for PSLT risk assessment; and, agreement rat lung cancer occurring only under conditions of lung particle overload does not imply a cancer hazard for humans under non-overloading exposures. Moreover, when askedshould PSLTs be considered as human lung carcinogens based on rat data alone (and no supporting data from other species), the expert consensus was: 'No. However, the experts noted the current default regulatory position on rat lung overload data alone would be the suspicion of human carcinogen hazard.' The many areas of the expert agreement provide guidance for design, interpretation, and extrapolating PSLT inhalation toxicology studies. Considering the workshop outcomes, the authors recommend guidelines for evaluation and classification of PSLT be reassessed; and, prior decisions on PSLT hazard classification be revisited to determine if they remain appropriate. ARTICLE HISTORY

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Lung cancer among coal miners, ore miners and quarrymen: smoking-adjusted risk estimates from the synergy pooled analysis of case–control studies

Cited by 33 publications

References 27 publications

Regional Inequalities in Lung Cancer Mortality in Belgium at the Beginning of the 21st Century: The Contribution of Individual and Area-Level Socioeconomic Status and Industrial Exposure

Regional Inequalities in Lung Cancer Mortality in Belgium at the Beginning of the 21st Century: The Contribution of Individual and Area-Level Socioeconomic Status and Industrial Exposure

Examining lung cancer risks across different industries and occupations in Ontario, Canada: the establishment of the Occupational Disease Surveillance System

Expert workshop on the hazards and risks of poorly soluble low toxicity particles

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