Exposure to bisphenol A is associated with recurrent miscarriage

Sugiura‐Ogasawara, Mayumi; Ozaki, Yasuhiko; Sonta, Shin-ichi; Makino, Tsunehisa; Suzumori, Kaoru

doi:10.1093/humrep/deh888

Cited by 363 publications

(215 citation statements)

References 26 publications

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“…The role of endocrine disruptors as the main source of exposure to exogenous estrogens has been focused in present study on the basis of tissue levels of Aryl hydrocarbon Receptor (AhR). AhR mediates the effects of many xenoestrogens and endocrine disruptors and contributes to the loss of normal ovarian function in polluted environments (Sugiura-Ogasawara, 2005;Valdez, 2009). We have detected its roles on the incidence of LMA in this case control study which was conducted in the most polluted and populated city of Iran, Tehran comparing with Mashhad as the second most populated city (not polluted) of Iran.We considered the existence of refinery center with 220,000 bbl/d installed capacity and extensive diesel exhaust in Tehran as the major source of difference between these two mentioned cities.Other than citizenship factors we looked for exposure to many other resources of exposure to endocrine disruptors by recording their food habits and lifestyle factors which may induce the AhR levels in target tissues (Zelieann, 2011).…”

Section: Discussionmentioning

confidence: 93%

Role of Endocrine Disrupting Chemicals in the Occurrence of Benign Uterine Leiomyomata: Special Emphasis on AhR Tissue Levels

Bidgoli¹,

Khorasani²,

Keihan³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 93%

Role of Endocrine Disrupting Chemicals in the Occurrence of Benign Uterine Leiomyomata: Special Emphasis on AhR Tissue Levels

Bidgoli¹,

Khorasani²,

Keihan³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…Seventeen studies have measured BPA in blood and serum samples from healthy male and nonpregnant female adults (Dirtu et al 2008;Fung et al 2000;He et al 2009;Hiroi et al 2004;Ikezuki et al 2002;Inoue et al 2000Inoue et al , 2001Kaddar et al 2009;Kuroda et al 2003;Liu et al 2007;Sajiki et al 1999;Sugiura-Ogasawara et al 2005;Takeuchi and Tsutsumi 2002;Takeuchi et al 2004;Volkel et al 2005;Yang M et al 2009;Yoshimura et al 2002) (Table 3). Of these studies, five used ELISA, one used a radioimmunoassay (RIA), and the remainder used analytical chemistry to assess BPA concentrations.…”

Section: Internal Dosage Assessment From Blood Measures Of Bpamentioning

confidence: 99%

“…For instance, BPA levels in blood have been associated with a variety of conditions in women, including obesity, endometrial hyperplasia, endometriosis, recurrent miscarriages, sterility, and PCOS (reviewed by Vandenberg et al 2007). Other studies detected associations between high BPA exposure and chromosomal abnormalities, including pregnancies with fetuses that had an abnormal karyotype (Yamada et al 2002), recurrent miscarriage (Sugiura-Ogasawara et al 2005), and sister chromatid exchange measured in peripheral lymphocytes (Yang et al 2006). These epidemiological studies have several limitations, including small sample sizes, insufficient information on subject selection criteria, and crosssectional designs that failed to adequately control for potential confounders (Vandenberg et al 2007), thus preventing accurate assessments regarding the potential health risks of BPA.…”

Section: Relationships Between Measured Bpa Concentrations and Diseasmentioning

confidence: 99%

Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A

Vandenberg

Chahoud

Heindel³

et al. 2012

Ciênc. saúde coletiva

332

331

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Estudos de biomonitoração do sistema urinário, circulatório e tecidos indicam grande exposição ao Bisfenol A Resumo Bisfenol A (BPA) é um dos produtos quí-micos mais produzido em todo o mundo, e a exposição humana a ele é considerada onipresente. Assim, há preocupações de que a quantidade de BPA para o qual os seres humanos estão expostos podem causar efeitos adversos à saúde. Nós examinamos muitas possibilidades sobre o porquê estudos de biomonitorização e toxicocinética podem chegar a conclusões aparentemente conflitantes. Mais de 80 estudos publicados de biomonitorização humana que mediram a concentração de BPA em tecidos humanos, urina, sangue e outros fluidos, juntamente com dois estudos de toxicocinéti-ca do metabolismo humano BPA foram examinados. BPA não conjugado foi detectado no sangue (nonanogramas por mililitro gama), e BPA conjugado foi detectado na grande maioria das amostras de urina. Em contraste, estudos de toxico-cinética propuseram que os seres humanos não são internamente expostos ao BPA. Dados disponíveis de estudos de biomonitorização indicam que a população em geral está exposta ao BPA e em risco de exposição interna ao BPA não conjugado. Os dois estudos de toxicocinética, que sugeriram a exposição humana ao BPA é insignificante, têm deficiências significativas e estão diretamente refutados por outros estudos e, portanto não são confiáveis para fins de avaliação de risco. Palavras-chave Disruptor endócrino, Exposição humana, Modelo PBPK/PBTK, Gravidez, Avaliação de risco, Toxicocinética Abstract Bisphenol A (BPA) is one of the highest-volume chemicals produced worldwide, and human exposure to BPA is thought to be ubiquitous. Thus, there are concerns that the amount of BPA to which humans are exposed may cause adverse health effects. We examined many possibilities for why biomonitoring and toxicokinetic studies could come to seemingly conflicting conclusions. More than 80 published human biomonitoring studies that measured BPA concentrations in human tissues, urine, blood, and other fluids, along with two toxicokinetic studies of human BPA metabolism were examined. Unconjugated BPA was routinely detected in blood (in the nanograms per milliliter range), and conjugated BPA was routinely detected in the vast majority of urine samples (also in the nanograms per milliliter range). In stark contrast, toxicokinetic studies proposed that humans are not internally exposed to BPA. Available data from biomonitoring studies clearly indicate that the general population is exposed to BPA and is at risk from internal exposure to unconjugated BPA. The two toxicokinetic studies that suggested human BPA exposure is negligible have significant deficiencies, are directly contradicted by hypothesis-driven studies, and are therefore not reliable for risk assessment purposes.

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“…Studies on xenoestrogens, such as methoxychlor (MXC) and bisphenoyl A (BPA), have shown that exposure to these chemicals also alters the Hoxa10 expression in female reproductive tract (Block et al 2000;Suzuki et al 2004;Fei et al 2005;Markey et al 2005;Sugiura-Ogasawara et al 2005;Daftary and Taylor 2006;Smith and Taylor 2007). MXC is a pesticide and this chemical is associated with female reproductive defects after either prenatal or postnatal exposure.…”

Section: Estrogens and Progesterone Regulate Hox Gene Expression In Tmentioning

confidence: 99%

The Role ofHoxGenes in Female Reproductive Tract Development, Adult Function, and Fertility

Taylor

2015

Cold Spring Harb Perspect Med

196

158

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HOX genes convey positional identity that leads to the proper partitioning and adult identity of the female reproductive track. Abnormalities in reproductive tract development can be caused by HOX gene mutations or altered HOX gene expression. Diethylstilbestrol (DES) and other endocrine disruptors cause Mü llerian defects by changing HOX gene expression. HOX genes are also essential regulators of adult endometrial development. Regulated HOXA10 and HOXA11 expression is necessary for endometrial receptivity; decreased HOXA10 or HOXA11 expression leads to decreased implantation rates. Alternation of HOXA10 and HOXA11 expression has been identified as a mechanism of the decreased implantation associated with endometriosis, polycystic ovarian syndrome, leiomyoma, polyps, adenomyosis, and hydrosalpinx. Alteration of HOX gene expression causes both uterine developmental abnormalities and impaired adult endometrial development that prevent implantation and lead to female infertility.

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Exposure to bisphenol A is associated with recurrent miscarriage

Abstract: Exposure to bisphenol A is associated with recurrent miscarriage.

Cited by 363 publications

References 26 publications

Role of Endocrine Disrupting Chemicals in the Occurrence of Benign Uterine Leiomyomata: Special Emphasis on AhR Tissue Levels

Role of Endocrine Disrupting Chemicals in the Occurrence of Benign Uterine Leiomyomata: Special Emphasis on AhR Tissue Levels

Urinary, Circulating, and Tissue Biomonitoring Studies Indicate Widespread Exposure to Bisphenol A

The Role ofHoxGenes in Female Reproductive Tract Development, Adult Function, and Fertility

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