Exposure to Bisphenol A increases malignancy risk of thyroid nodules in overweight/obese patients

Marotta, Vincenzo; Grumetto, Lucia; Neri, Ilaria; Russo, Giacomo; Tortora, Anna; Izzo, Giulia; Panariello, I.; Rocco, Domenico; Pezzullo, Luciano; Vitale, Mario

doi:10.1016/j.envpol.2022.120478

Cited by 10 publications

(5 citation statements)

References 58 publications

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“…To evaluate the role of estradiol (E2) or E2-like environmental substance such as BPA in TC had an important significance for understanding the mechanism for thyroid cancer. However, there are limited evidence about the E2/ BPA affecting the TC via long no coding RNA [17,18]. Long non-coding RNA (LncRNA) is involved in multiple processes such as mRNA stability, translation, and post-translational modification in tumor occurrence and development [19,20].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: LINC00623 play important roles in Pan-cancer and Thyroid papillary cancer

Wang,

Zhang,

Liang

et al. 2024

Preprint

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BACKGROUND Papillary thyroid cancer (PTC), accounts for approximately 90% of all thyroid cancer cases, the underlying mechanism was unclear. LINC00623 was a new proved epigenetic modification(ac4C) gene. However, the study about the role of LINC00623 in pan cancer and thyroid cancer induced by estradiol (E2) have not yet been explored. METHODS Pan-cancer analysis based on TCGA was carried out by Sanger box. Different gene expressions were analyzed by DESeq2 Package. Receiver-operating characteristic (ROC) curves were used to evaluate the diagnostic value of it for Pan cancer and THCA. Overall survival was calculated by the Kaplan–Meier univariate and cox multivariate analyses. In vitro, after knockdown of LINC00623, MTT/clone formation/Cell cycle and apoptosis were carried out. E2/ Bisphenol (BPA) stimulation and GSK inhibition experiment was carried out. RESULTS LINC00623 play an important role in diagnosis and prognosis in pan cancer and THCA.LINC00623 is an important biological indicator of immune microenvironment and immune infiltrating cells in pan-cancer and THCA. We first verified that E2 and BPA could induce the expression of LINC00623 in PTC cell lines. In vitro experiments verified that LINC00623 significantly affected the biological process of PTC such as proliferation, cycle, and apoptosis. Mechanism exploration identified LINC00623 affected the epigenetics of PTC, namely H3K27me3 and H3K36me3 through PHF19. The LINC00623 promote the progress of BHP10-3 cell acting as an oncogene; LINC00623 knock down increased the H3K27me3 and down regulated the H3K27me3 via PHF19, GSK126 can rescue the cell biological inhibition caused by LINC00623 knock down. Conclusion LINC00623 play a significant role in pan-cancer and thyroid cancer. E2/BPA can induce the expression of LINC00623.LINC00623 was an epigenetic regulator of H3K27me3 and H3K36me3 via PHF19 in PTC. It can be a potential therapy target for PTC.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: LINC00623 play important roles in Pan-cancer and Thyroid papillary cancer

Wang,

Zhang,

Liang

et al. 2024

Preprint

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“…At the receptor level, BPA binds to the thyroid hormone receptor (TR) as a weak ligand and functions as an antagonist to T3, thereby preventing TR-mediated transcriptional activity [ 29 , 69 ]. In a recent study, Marotta et al 2022 found that overweight/obese individuals subjects exposed to BPA showed high serum level of TSH [ 70 ]. This can sustain the hypothesis that BPA play role in TC development via thyroid hormones dysregulation, which in turn leads to TSH hyperstimulation and increased TC risk [ 70 ].…”

Section: Pollutantsmentioning

confidence: 99%

“…In a recent study, Marotta et al 2022 found that overweight/obese individuals subjects exposed to BPA showed high serum level of TSH [ 70 ]. This can sustain the hypothesis that BPA play role in TC development via thyroid hormones dysregulation, which in turn leads to TSH hyperstimulation and increased TC risk [ 70 ]. Fetuses and infants are especially susceptible to the consequences of BPA exposure, according to the current fetal genesis hypothesis of cancer [ 28 ].…”

Section: Pollutantsmentioning

confidence: 99%

Thyroid Carcinoma: A Review for 25 Years of Environmental Risk Factors Studies

Kruger

Toraih

Hussein

et al. 2022

Cancers

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Environmental factors are established contributors to thyroid carcinomas. Due to their known ability to cause cancer, exposure to several organic and inorganic chemical toxicants and radiation from nuclear weapons, fallout, or medical radiation poses a threat to global public health. Halogenated substances like organochlorines and pesticides can interfere with thyroid function. Like phthalates and bisphenolates, polychlorinated biphenyls and their metabolites, along with polybrominated diethyl ethers, impact thyroid hormones biosynthesis, transport, binding to target organs, and impair thyroid function. A deeper understanding of environmental exposure is crucial for managing and preventing thyroid cancer. This review aims to investigate the relationship between environmental factors and the development of thyroid cancer.

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“…The obesity-related cancer burden in 2016 represented up to 9% of the cancer burden among women in North America, Europe, and the Middle East [ 8 ]. It was suggested that bisphenol A (BPA) exposure is considered as a risk factor for thyroid cancer in overweight/obese subjects [ 9 ]. Despite the widely unknown causal factors, there is a deep knowledge of underline genetics of thyroid cancer [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Human exposure to pesticides and thyroid cancer: a worldwide systematic review of the literatures

2023

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Thyroid cancer is considered as one of the most prevalent cancers in the world. Some pesticides can play a role as a potentially important risk factor in thyroid cancer by affecting thyroid morphology and thyroid hormone homeostasis. The aim of present study was to systematically review the available epidemiological evidence for human exposure to pesticides and thyroid cancer. Articles were searched in PubMed, Scopus and Web of Science by suitable keywords from January 2000 to May 2021. Standard techniques for systematic reviews were followed in the current study and results reported according to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Based on the inclusion and exclusion criteria, finally seven studies including four cohort studies and three case-control studies were reviewed. Organochlorines (OCPs) in more cases, Organophosphates (OPs) and Carbamates insecticides, herbicides and fungicides were the studied pesticides. Inconsistent results were reported in the surveyed articles on the OCPs. Two articles on the Carbamates (Carbaryl and Mancozeb) showed consistently an inverse association between exposure and thyroid cancer. Increased risk of thyroid cancer due to the exposure to the Malathion was reported in one article on the OPs. Due to the limited current knowledge about the effect of pesticides on thyroid cancer in humans, human health policies must be implemented to control individual’s exposure to chemicals through using of botanical pesticides in agricultural. Also, more studies must be done to fill this gap of knowledge.

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Exposure to Bisphenol A increases malignancy risk of thyroid nodules in overweight/obese patients

Cited by 10 publications

References 58 publications

RETRACTED: LINC00623 play important roles in Pan-cancer and Thyroid papillary cancer

RETRACTED: LINC00623 play important roles in Pan-cancer and Thyroid papillary cancer

Thyroid Carcinoma: A Review for 25 Years of Environmental Risk Factors Studies

Human exposure to pesticides and thyroid cancer: a worldwide systematic review of the literatures

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