1999
DOI: 10.1038/44517
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Exposure to bisphenol A advances puberty

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Cited by 766 publications
(478 citation statements)
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“…For example, Howdeshell et al (1999) found that administration of BPA to offspring female mice at a dose that is within the range typical of environmental exposure affected the postnatal growth rate, causing early puberty. Khurana et al (2000) reported BPA, given to maternal rats for a period extending from prior to mating until weaning of the pups, reduced male offspring motivation to explore, while in females motor activity was also depressed.…”
Section: Discussionmentioning
confidence: 99%
“…For example, Howdeshell et al (1999) found that administration of BPA to offspring female mice at a dose that is within the range typical of environmental exposure affected the postnatal growth rate, causing early puberty. Khurana et al (2000) reported BPA, given to maternal rats for a period extending from prior to mating until weaning of the pups, reduced male offspring motivation to explore, while in females motor activity was also depressed.…”
Section: Discussionmentioning
confidence: 99%
“…This study established that in utero BPA exposure during the formation period of reproductive organ in F1 mice could alter histology and methylation pattern in the reproductive organ of F2 who had no experience in BPA exposure. Since it was known that the body weight in F2 generation was increased by BPA exposure to F1 at the fetal and the lactational periods [6,11], it is most likely that the increase of body weight in our study was due to BPA exposure. The uterus relative weight was decreased significantly, which seemed to be involved with incomplete development of the endometrium, as reported previously [7].…”
mentioning
confidence: 90%
“…There are a lot of reports about effects of BPA on formation and function of female reproductive organs. Among these reports, well known are (i) that BPA exposure advanced puberty [6], (ii) that BPA exposure changed patterns of estrous cycle [11], (iii) that BPA exposure brought about the loss of uterine decidualization [13], and (iv) that BPA exposure decreased the endometrial weight and increased expressions of estrogen receptor  and progesterone receptor [7]. We previously reported that BPA exposure during implantation and placentation periods decreased the number of fetus and pups, and the survival rate before weaning [14].…”
mentioning
confidence: 99%
“…There is increasing evidence that prenatal exposure to BPA affects the development of living animals. It has been reported that administration of BPA to pregnant mice at a dose that is within the range of the environmental levels that humans are typically exposed to causes remarkable changes in the postnatal growth rate and leads to early onset of puberty in these mice (Howdeshell et al, 1999). Recently, it has been reported that prenatal exposure to BPA disrupts the brain sexual differentiation and sociosexual behaviors in rats (Kubo et al, 2001;Farabollini et al, 2002).…”
Section: Introductionmentioning
confidence: 99%