Exposure to ambient air pollution during trimesters of pregnancy and childhood allergic diseases in Wuhan, China

Guo, Menglan; Wei, Liqing; Yan, Hong; Duan, Zhizhou; Niu, Zhiping; Xiao, Chenchang

doi:10.1080/09603123.2021.1929873

Cited by 12 publications

(4 citation statements)

References 49 publications

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“…It should be noted that no significant association was found between PM10, particulate matter of 10 micrometers, and asthma and allergic rhinitis, as reported in the Liu study [15]. Moreover, SO 2 showed no significant association with any of the respiratory illnesses studied, as evidenced across multiple studies, including those conducted by Guo, Liu, and Seeni [10,14,15].…”

Section: Discussionmentioning

confidence: 65%

“…Publication bias was evaluated using funnel plots cian-assessed pneumonia, and transient tachypnea (95% CI: 1.09-1.13) as supported by studies by Seeni, Kinney, and Lee [10][11][12]. Likewise, prenatal exposure to NO x was associated with a 1.46 times higher risk of child respiratory health issues, such as respiratory tract infections, allergic diseases, allergic rhinitis, asthma, and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), with a summary RR of 1.46 (95% CI: 1.09-1.60) as supported by studies by Madsen, Guo, Liu, and Seeni [10,[13][14][15].…”

Section: Discussionmentioning

confidence: 75%

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Association Between Maternal Prenatal Exposure to Household Air Pollution and Child Respiratory Health: A Systematic Review and Meta-analysis

Saxena

2024

Yale J Biol Med

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Maternal prenatal exposure to household air pollution (HAP) is a critical public health concern with potential long-term implications for child respiratory health. The objective of this study is to assess the level of association between prenatal household air pollution and child respiratory health, and to identify which HAP pollutants are associated with specific respiratory illnesses or symptoms and to what degree. Relevant studies were retrieved from PubMed databases up to April 27, 2010, and their reference lists were reviewed. Random effects models were applied to estimate summarized relative risks (RRs) and 95% confidence intervals (CIs). The analysis involved 11 studies comprising 387 767 mother-child pairs in total, assessing various respiratory health outcomes in children exposed to maternal prenatal HAP. Children with prenatal exposure to HAP pollutants exhibited a summary RR of 1.26 (95% CI=1.08-1.33) with moderate between-study heterogeneity (I²=49.22%) for developing respiratory illnesses. Specific associations were found between prenatal exposure to carbon monoxide (CO) (RR=1.11, 95% CI: 1.09-1.13), Nitrogen Oxides (NO x ) (RR=1.46, 95% CI: 1.09-1.60), and particulate matter (PM) (RR=1.26, 95% CI: 1.2186-1.3152) and child respiratory illnesses (all had I² close to 0%, indicating no heterogeneity). Positive associations with child respiratory illnesses were also found with ultrafine particles (UFP), polycyclic aromatic hydrocarbons (PAH), and ozone (O 3 ). However, no significant association was observed for prenatal exposure to sulfur dioxide (SO 2 ). In summary, maternal prenatal exposure to HAP may contribute to a higher risk of child respiratory health issues, emphasizing the need for interventions to reduce this exposure during pregnancy. Targeted public health strategies such as improved ventilation, cleaner cooking technologies, and awareness campaigns should be implemented to minimize adverse respiratory effects on children.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 75%

Association Between Maternal Prenatal Exposure to Household Air Pollution and Child Respiratory Health: A Systematic Review and Meta-analysis

Saxena

2024

Yale J Biol Med

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“…The broader understanding of this meta-analysis revealed that exposure to industrial hazards and outdoor air pollution in pregnant mothers is the largest group of risk modifiable factors that raises the risk of AD in young kids. Previous studies have also highlighted eczema as an environmental disease 55 56 . In addition to environmental factors, dietary factors also play a significant role.…”

Section: Discussionmentioning

confidence: 99%

Prenatal Maternal Risk Factors Contributing to Atopic Dermatitis: A Systematic Review and Meta-Analysis of Cohort Studies

Cui

2023

Ann Dermatol

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Background The gestational risk factors predispose to the manifestation of early childhood atopic dermatitis (AD). Objective We evaluated the association between modifiable and non-modifiable gestational and prenatal risk factors that affect the AD prevalence in children. Methods We performed the systematic review and meta-analysis of cohort studies (n=27) in PubMed and EMBASE (2000~2021). A meta-analysis was performed using random-effects models to estimate pooled odds ratios (OR) or hazard ratio (HR). We performed a systematic review according to Preferred Reporting Item for Systematic Review and Meta-Analyses (PRISMA) guidelines and summarized cohort studies investigating gestational and prenatal risk factor those predispose to AD in off spring. Leading modifiable and non-modifiable were identified through ORs. Meta-analysis using the random effect model was also conducted to provide an overall estimate for several significant factors. Results Among the non-modifiable risk factors gestational diabetes (7.2, 95% confidence interval [CI]: 1.4~34.5), maternal history of allergy (2.14, 95% CI: 1.54~2.97) and prenatal history of eczema (2.46, 95% CI: 1.0~5.8) were found as major determining risk factors in early manifestation of AD in children. Further, maternal exposure to industrial products (1.89, 95% CI: 1.10~3.16), exposure to antibiotics during pregnancy (3.59, 95% CI: 1.19~10.85) and passive smoking during pregnancy (2.60, 95% CI: 1.11~6.1) are leading causes of early AD manifestation. Conclusion Conclusively, both genetic and environmental factors play a pivotal role in early manifestation of AD. The better managing the environmental factors during gestational phase to the least can help curtail the prevalence of AD in children.

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“…In particular, severe AR has been associated with significant impairments in quality of life, work performance, and sleep [39,40]. Increasing epidemiological studies conducted both on adults and children have been reporting an associative relationship between air pollution, including PM, and increased incidence of AR [7,9,[41][42][43][44][45][46]. Indeed, allergens and environmental agents trigger reactive nasal inflammatory conditions such as AR via the involvement of host intrinsic factors, including the innate and adaptive immune system, as well as the bNM membership [47,48].…”

Section: Discussionmentioning

confidence: 99%

Particulate Matter Exposure and Allergic Rhinitis: The Role of Plasmatic Extracellular Vesicles and Bacterial Nasal Microbiome

Mariani

Iodice

Cantone

et al. 2021

IJERPH

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Particulate matter (PM) exposure is linked to the worsening of respiratory conditions, including allergic rhinitis (AR), as it can trigger nasal and systemic inflammation. To unveil the underlying molecular mechanisms, we investigated the effects of PM exposure on the release of plasmatic extracellular vesicles (EV) and on the complex cross-talk between the host and the nasal microbiome. To this aim, we evaluated the effects of PM10 and PM2.5 exposures on both the bacteria-derived-EV portion (bEV) and the host-derived EVs (hEV), as well as on bacterial nasal microbiome (bNM) features in 26 AR patients and 24 matched healthy subjects (HS). In addition, we assessed the role exerted by the bNM as a modifier of PM effects on the complex EV signaling network in the paradigmatic context of AR. We observed that PM exposure differently affected EV release and bNM composition in HS compared to AR, thus potentially contributing to the molecular mechanisms underlying AR. The obtained results represent the first step towards the understanding of the complex signaling network linking external stimuli, bNM composition, and the immune risponse.

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Exposure to ambient air pollution during trimesters of pregnancy and childhood allergic diseases in Wuhan, China

Cited by 12 publications

References 49 publications

Association Between Maternal Prenatal Exposure to Household Air Pollution and Child Respiratory Health: A Systematic Review and Meta-analysis

Association Between Maternal Prenatal Exposure to Household Air Pollution and Child Respiratory Health: A Systematic Review and Meta-analysis

Prenatal Maternal Risk Factors Contributing to Atopic Dermatitis: A Systematic Review and Meta-Analysis of Cohort Studies

Particulate Matter Exposure and Allergic Rhinitis: The Role of Plasmatic Extracellular Vesicles and Bacterial Nasal Microbiome

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