Exposure to a Brazilian pulp mill effluent impacts the testis and liver in the zebrafish

Castro, Allisson Jhonatan Gomes; Baptista, Ivana Eunice; Moura, Kieiv Resende Sousa de; Padilha, Fernanda Yasmin Odila Maestri Miguel; Tonietto, Juliana; Zamoner, Ariane; Soares, Carlos Henrique Lemos; Silva, Fátima Regina Mena Barreto; Kraak, Glen Van Der

doi:10.1016/j.cbpc.2018.02.005

Cited by 10 publications

(12 citation statements)

References 41 publications

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“…Additionally, lactate is needed for RNA and protein synthesis stimulation in spermatids (Jutte et al, 1981) and exerts an antiapoptotic effect on germ cells (Erkkilä et al, 2002). These findings were consistent with our previous work in which male fish D. rerio exposed to 4% effluent for 14 days had decreased testis lactate content (Castro et al, 2018). Surprisingly, in the present study, the decrease in lactate content was not accompanied by the decrease in the activity of its synthesizing enzyme, LDH, which was unchanged.…”

Section: Discussionsupporting

confidence: 93%

“…Pro-oxidant pulp mill effluent activity in the testis has already been shown by Castro et al (2018). No change in ROS, RNS and TBARS content parameters was different what expected in our initial hypothesis.…”

Section: Discussionsupporting

confidence: 63%

“…Effluent was collected after the last step of treatment and immediately before being released to the Canoas River. Testing of the effluent at a 4% dilution was based on previous studies of the toxicity of effluent from this mill on D. rerio and reflected local river concentrations of the effluent (Castro et al, 2018). In addition, concentrations of 2% and 8% were also tested only in the calcium influx experiment in order to obtain a dose-response curve for the effluent.…”

Section: Pulp and Paper Mill Effluentmentioning

confidence: 99%

“…Effluent is a yellowish liquid. The chemical analysis was previously described by Castro et al (2018): high amount of total phenols (3.8 mg/L) and acid resins (9.3 mg/L) and steroids below the detection limit.…”

Section: Pulp and Paper Mill Effluentmentioning

confidence: 99%

“…Recent studies show that exposure to pulp and paper mill effluent can cause deleterious effects on fish reproduction such as increased plasma concentrations of vitellogenin in females and males and the presence of intersex characteristics in males of Onchorhynchus mykiss ( Chiang et al, 2015 ) and decreased oviposition in females of Pimephales promelas ( Waye et al, 2014 ). A recent study from our research group showed that pulp mill effluent may adversely affect testis function of Danio rerio fish ( Castro et al, 2018 ). However, there is a lack of studies reporting the impacts of pulp and paper mill effluent on reproduction in other taxonomic groups, such as mammals.…”

Section: Introductionmentioning

confidence: 99%

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A Brazilian pulp and paper mill effluent disrupts energy metabolism in immature rat testis and alters Sertoli cell secretion and mitochondrial activity

et al. 2020

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Our objective was to investigate whether the pulp and paper mill industry effluent could affect the testis and Sertoli cells in a fast exposure period. For this, the present study was carried out in immature rats at 10-day-old. Testis treated in vitro with 4% effluent for 1 h presented changes in energy metabolism in terms of a decrease in lactate content and glucose uptake. Elevation in GSH content, as an antioxidant defense mechanism, was also detected. Sertoli cells treated with 4% effluent for 1 hour showed alterations in the mitochondrial metabolism that favor the decoupling of oxidative phosphorylation and the generation of oxygen reactive species and also a time and concentration-dependent delay secretion of acidic vesicles. Our results showed that pollutants present in the pulp and paper mill effluents, in a short time of exposure, are capable of inducing alterations in important metabolic functions in the testis and in Sertoli cells that are crucial for the correct progression of spermatogenesis and fertility.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 63%

Section: Pulp and Paper Mill Effluentmentioning

confidence: 99%

Section: Pulp and Paper Mill Effluentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Brazilian pulp and paper mill effluent disrupts energy metabolism in immature rat testis and alters Sertoli cell secretion and mitochondrial activity

et al. 2020

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In vivo exposure to pyriproxyfen causes ovarian oxidative stress and inhibits follicle maturation in zebrafish

Oliveira

Marins

Mendes

et al. 2023

J of Applied Toxicology

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We analyzed the effects of pyriproxyfen (PPF) on oxidative stress and ovarian morphology in zebrafish. PPF (10−9 M) exposure increased reactive oxygen species generation in ovaries, in association with a decrease in glutathione content. The activities of glutathione S‐transferase, superoxide dismutase, and catalase were increased, while γ‐glutamyltransferase activity was not altered by pesticide treatment. The histology of ovarian tissue showed an increase in the number of previtellogenic oocytes I, and a decrease in the rate of vitellogenic oocyte (VIT) count, suggesting inhibition of follicular maturation. An increase in the thickness of the vitelline envelope was observed in VIT, as was a tendency toward an increase in atresia in the ovary of the PPF‐treated group. These findings indicate that the deleterious effect of PPF on ovarian maturation is mediated by a redox imbalance and oxidative damage. So, PPF acts as an endocrine disruptor chemical and may compromise fish reproduction by reducing female fertility.

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Characteristics and treatment of Brazilian pulp and paper mill effluents: a review

Ramos

Rangel

Azevedo

et al. 2022

Environ Monit Assess

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Pulp and paper industries are very important for developing the Brazilian economy. During production processes, many effluents are generated with high polluting potential. The objective of this study is to conduct an extensive literature review on the characteristics of effluents and treatment forms adopted by Brazilian mills in this industrial sector. Most consulted studies address raw (without treatment) and secondary (after biological treatment) effluents, considering their main characteristics like pH, chemical and biochemical oxygen demands (COD and BOD, respectively), color, solids, organochlorines, toxicity, estrogenic activity, and phenols. Raw effluents differ considerably in composition, depending on the type of paper produced, the pulping process employed, and other steps, like pulp bleaching. Raw effluent characteristics indicate that this effluent cannot be directly disposed of into water bodies, because it does not comply with federal and state disposal standards. Secondary effluents normally comply with Brazilian legislations, although some studies have reported COD and total phenol concentrations higher than disposal standards, suggesting that additional treatments are necessary. Treated effluent reuse was verified in some Brazilian mills, while its disposal in eucalyptus plantations has been considered a promising alternative for irrigation purposes.

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Exposure to a Brazilian pulp mill effluent impacts the testis and liver in the zebrafish

Cited by 10 publications

References 41 publications

A Brazilian pulp and paper mill effluent disrupts energy metabolism in immature rat testis and alters Sertoli cell secretion and mitochondrial activity

A Brazilian pulp and paper mill effluent disrupts energy metabolism in immature rat testis and alters Sertoli cell secretion and mitochondrial activity

In vivo exposure to pyriproxyfen causes ovarian oxidative stress and inhibits follicle maturation in zebrafish

Characteristics and treatment of Brazilian pulp and paper mill effluents: a review

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