Exposure of the French population to bisphenols, phthalates, parabens, glycol ethers, brominated flame retardants, and perfluorinated compounds in 2014–2016: Results from the Esteban study

Urinary levels of parabens, phthalate metabolites, bisphenol A and plasticizer alternatives in a Belgian population: Time trend or impact of an awareness campaign?

“…Because the exposure of the worldwide population to these endocrine disruptors was demonstrated to be age and/or gender dependent likely due to difference in lifestyle habits (food consumption, cosmetic uses, time spent indoors, etc) (Bastiaensen et al, 2021;Dewalque et al, 2014;Geens et al, 2014;Hartmann et al, 2015;Giovanoulis et al, 2016;Lim, 2020;Park et al, 2019;Saravanabhavan et al, 2013) and has been decreased since the early 2000s (Bastiaensen et al, 2021;Kim et al, 2021;Koch et al, 2017;Reyes and Price, 2018;Tranfo et al, 2018;Wittassek et al, 2007;Zota et al, 2014), the results obtained were compared with those from some large scale studies carried out on mixed-gender adult populations recruited within a similar time period (between 2012 and 2016) and gathered in Table 5. The urinary levels of parabens in the present Belgian adult population were similar to those measured in the urine of some French and Dutch populations (Balicco et al, 2019b;Fillol et al, 2021;Van der Meer et al, 2021), but considerably lower than those reported from Australia (Heffernan et al, 2015), Canada (Health Canada, 2017) or the United States (CDC, 2019) where the chemicals in PCP and cosmetics are drastically less regulated than in Europe (Sarantis et al, 2011). The higher urinary levels of parabens measured within the Norwegian RHINESSA study (Vindenes et al, 2021) would at least partly be explained by the later implementation of the 2014's EU regulation on parabens in Norway (Vindenes et al, 2021), the younger study population, and the different patterns of PCP and cosmetic uses.…”

“…Similarly, all bisphenol alternatives were measured in higher concentrations in 2018 vs 2015 although these concentrations remained low compared to BPA, and higher urinary levels of BPS and BPF were reported from France (Balicco et al, 2019b;Table 4 Comparison between marker levels measured in the samples collected in 2015 and 2018 from volunteers participating to both campaigns (in μg/L). C. Pirard and C. Charlier Fillol et al, 2021), Norway (Vindenes et al, 2021) or US (CDC, 2019). On the other side, steady BPA level was observed between 2015 and 2018 contrariwise to the worldwide general trend highlighted this last decade (CDC, 2019;Frederiksen et al, 2020;Gyllenhammar et al, 2017;Gys et al, 2021;Huang et al, 2018;Van der Meer et al, 2021) and despite the different EU regulations aimed to restrict BPA uses and set in the same time frame than those related to phthalates (Table 6).…”

PFAS levels and determinants of variability in exposure in European teenagers – Results from the HBM4EU aligned studies (2014–2021)

“…Questionnaires were filled out by interviewer or the study participants themselves and/or their parents. 9 out of 11 European studies of teenagers included in the aligned studies determined PFAS concentrations in blood samples: ESTEBAN (Étude de santé sur l'environnement, la biosurveillance, l'activité physique et la nutrition; France; Fillol et al, 2021 ), GerES V-sub (German Environmental Survey, 2014–2017, unweighted subsample; Germany; Schultz et al, 2021 ), Riksmaten Adolescents 2016–17 (Sweden; Moraeus et al, 2018 ), NEBII (Norwegian Environmental Biobank II; Norway; Magnus et al, 2016 ), FLEHS IV (Flemish Environment and Health Study IV; Belgium; Schoeters et al, 2022 ), BEA (Biomonitorización en Adolescentes; Spain; Pérez-Gómez et al, 2013 ), SLO CRP (Exposure of children and adolescents to selected chemicals through their habitat environment; Slovenia; Stajnko et al, 2020 ), PCB cohort follow-up (Endocrine disruptors and health in children and teenagers in Slovakia; Slovakia; Hertz-Picciotto et al, 2003 ) and CROME (Cross-Mediterranean Environment and Health Network; Greece) ( Table 1 ). All studies had obtained ethical approval and all participants or their legal guardians signed an informed consent prior to participation.…”

The Identification of certain chemical disruptors of the estrogen receptor α: Structural and docking analyses

“…The initial negative impacts of EDCs were linked to estrogens and included learning difficulties, endometriosis, breast cancer, and issues with fertility (5). EDCs are currently viewed as a hazard to public health due to the possibility that human exposure to these substances would raise the likelihood of biological processes including reproduction, cognition, and metabolism being impaired (6).…”