Exposure of neonates to Respiratory Syncytial Virus is critical in determining subsequent airway response in adults

You, Dahui; Becnel, David; Wang, Kai; Ripple, Michael; Daly, Melissa; Cormier, Stephania A.

doi:10.1186/1465-9921-7-107

Cited by 103 publications

(120 citation statements)

References 29 publications

(34 reference statements)

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“…Neutrophils respond to TNF-a with a respiratory burst after a b 2 -integrin-dependent adherence to extracellular matrix proteins (Decleva et al, 2002). TNF-a has been proposed as an ideal drug target for the therapy of RSVinduced bronchiolitis (Rutigliano & Graham, 2004;You et al, 2006). Overall, our study points to a role for innate immunity in RSV disease, a conclusion that was also drawn from a genetic-association study in children (Janssen et al, 2007).…”

Section: A F G Antonis and Otherssupporting

confidence: 67%

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Age-dependent differences in the pathogenesis of bovine respiratory syncytial virus infections related to the development of natural immunocompetence

Antonis

Jong

Poel

et al. 2010

Journal of General Virology

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Section: A F G Antonis and Otherssupporting

confidence: 67%

“…However, when in excess, TNF-a can provoke chronic inflammatory disorders. You et al (2006) recently published the results of a study in a neonatal-mouse model and suggested that TNF-a plays a key role in mediating chronic inflammation (e.g. asthma) of the bronchi after RSV infection.…”

Section: A F G Antonis and Othersmentioning

confidence: 99%

Age-dependent differences in the pathogenesis of bovine respiratory syncytial virus infections related to the development of natural immunocompetence

Antonis

Jong

Poel

et al. 2010

Journal of General Virology

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“…Finally, rodent models suggest that respiratory viral infections of immature and mature animals (90) result in chronic pathologic changes in the lung, airway hyperreactivity, and immune system changes similar to those seen in human asthma (98)(99)(100)(101). In addition, these early-life infections may alter subsequent responses to viral infection in adult animals (102,103).…”

Section: Biologic Mechanisms Through Which Respiratory Viral Infectiomentioning

confidence: 99%

Toward Primary Prevention of Asthma. Reviewing the Evidence for Early-Life Respiratory Viral Infections as Modifiable Risk Factors to Prevent Childhood Asthma

Feldman

Moore

et al. 2015

Am J Respir Crit Care Med

171

172

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A first step in primary disease prevention is identifying common, modifiable risk factors that contribute to a significant proportion of disease development. Infant respiratory viral infection and childhood asthma are the most common acute and chronic diseases of childhood, respectively. Common clinical features and links between these diseases have long been recognized, with early-life respiratory syncytial virus (RSV) and rhinovirus (RV) lower respiratory tract infections (LRTIs) being strongly associated with increased asthma risk. However, there has long been debate over the role of these respiratory viruses in asthma inception. In this article, we systematically review the evidence linking early-life RSV and RV LRTIs with asthma inception and whether they could therefore be targets for primary prevention efforts.

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“…26 In se ve ral stu di es, it was shown that IL-4, IL-13 and IFN-γ le vels in cre a sed af ter RSV in fec tion. [27][28][29] However no re la ti on was shown bet we en IL-4, IFN-γ le vels and re cur rent whe e zing epi sodes. 30 In our study, IL-13 levels were not dif fe rent in RSV po si ti ve and ne ga ti ve ca ses but IL-4 and IFN-γ le vels we re sig ni fi cantly hig her in the non-RSV gro up.…”

Section: Discussionmentioning

confidence: 99%

Recurrence of Wheezing Episodes in Children with Respiratory Syncytial Virus and Non-Respiratory Syncytial Virus Bronchiolitis

Karaman¹,

Gunes²,

Erbayraktar³

et al. 2011

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : It has be en shown that many chil dren who ex pe ri en ce res pi ra tory syncyti al vi rus (RSV) in fec ti on in in fancy de ve lop re cur rent whe e zing epi so des and ast hma la ter. Viral ro le in pat ho ge ne sis of ast hma is still a de ba te. We ai med to in ves ti ga te the re cur ren ce of whe e zing epi so des, atopy and se rum cyto ki ne le vels in chil dren en co un te red with RSV in fec tion. Ad di ti o nally, we ai med to com pa re the se pa ra me ters in chil dren with non-RSV bronc hi o litis. M Ma at te er ri ia al l a an nd d M Me et t h ho od ds s: : The study was con duc ted bet we en Ja nu ary 2006 and No vem ber 2008 in Do kuz Ey lul Uni ver sity hos pi tal. Se venty chil dren aged bet we en 0-36 months who we re diag no sed with acu te bronc hi o li tis for the first ti me we re rec ru i ted for the study. Na sop hary ngeal la va ge flu id was analy zed with poly me ra se cha in re ac ti on (PCR) for RSV an ti gen in all pa ti ents. Se rum im mu nog lo bu lin E, to tal eo si nop hil co unt, in ter le u kin (IL)-4, IL-13 and γ-in terfe ron (IFN-γ) le vels we re ob ta i ned at the last exa mi na ti on of the pa ti ents af ter a fol low up pe riod of 1-3 ye ars. R Re e s su ul lt ts s: : Re cur ren ce of a whe e zing epi so de was ob ser ved in 35% and 53.3% of the pa ti ents in RSV gro up and non-RSV gro up, res pec ti vely (p= 0.064). Me an se rum IFN-γ and IL-4 le vels we re de tec ted to be sig ni fi cantly hig her in non-RSV gro up. No sig ni fi cant re la ti on was de tec ted bet we en re cur ren ce of whe e zing epi so des and to tal eo si nop hil co unt, se rum IgE, IL-4, IL-13, and IFN-γ le vels. C Co on nc c l lu u s si i o on n: : No dif fe ren ce co uld be de tec ted bet we en RSV and non-RSV bronc hi o li tis re gar ding sub se qu ent whe e zing epi so des. Alt ho ugh se rum IL-4 and IFN-γ levels we re hig her in non-RSV bronc hi o li tis gro up, no sig ni fi cant cor re la ti on was ob ser ved bet we en the se pa ra me ters and re cur ren ce of whe e zing epi so des. K Ke ey y W Wo or rd ds s: : Asthma; bronchiolitis Ö ÖZ ZE ET T A Am ma aç ç: : Süt çocukluğu döneminde respiratuvar sinsityal virus (RSV) infeksiyonu geçiren çocukların daha sonra hışıltı atakları ve astım geçirdikleri gösterilmiştir. Astımın patogenezinde virüslerin rolü halen tartışmalıdır. RSV infeksiyonu ile karşılaşan çocuklarda hışıltı ataklarının tekrarlamasını, atopi ve serum sitokin düzeylerini araştırmayı ,ayrıca bu parametreleri RSV-dışı bronşioliti olan çocukların sonuçları ile karşılaştırmayı amaçladık. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışma Ocak 2006 ile Kasım 2008 arasında Dokuz Eylül Üniversitesi Hastanesinde gerçekleştirildi. İlk kez akut bronşiolit tanısı koyulan 0-36 ay yaş aralığında 70 çocuk çalışmaya alındı. Tüm hastalarda nazofarenjiyal lavaj sıvısı RSV antijeni bakımından polimeraz zincir reaksiyonu (PCR) ile incelendi. Bir ila üç yıllık takip süresinden sonra hastaların son muayenelerinde serum immunoglobuli...

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Exposure of neonates to Respiratory Syncytial Virus is critical in determining subsequent airway response in adults

Cited by 103 publications

References 29 publications

Age-dependent differences in the pathogenesis of bovine respiratory syncytial virus infections related to the development of natural immunocompetence

Age-dependent differences in the pathogenesis of bovine respiratory syncytial virus infections related to the development of natural immunocompetence

Toward Primary Prevention of Asthma. Reviewing the Evidence for Early-Life Respiratory Viral Infections as Modifiable Risk Factors to Prevent Childhood Asthma

Recurrence of Wheezing Episodes in Children with Respiratory Syncytial Virus and Non-Respiratory Syncytial Virus Bronchiolitis

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