Exposure of aerosols and nanoparticle dispersions to in vitro cell cultures: A review on the dose relevance of size, mass, surface and concentration

Grass, Robert N.; Limbach, Ludwig K.; Athanassiou, Evagelos K.; Stark, Wendelin J.

doi:10.1016/j.jaerosci.2010.10.001

Cited by 51 publications

(45 citation statements)

References 107 publications

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“…Grass et al [41] demonstrated that risks associated specifi cally with nanoparticles stem ultimately from three sources: large interfacial area, the possibility of quantum effects and non-conventional mobility factors (agglomeration, toxicokinetics, translocation, accumulation). However, their studies were essentially conducted in vitro and did not take exposure factors into consideration.…”

Section: Enp Hazardsmentioning

confidence: 99%

“…High-risk properties of ENP products could be examined from the perspective of their potential for interactions with other objects, which may be living or not [41]. Among the more notable interfacial properties cited in the literature are interfacial tension and surface charge or zeta potential.…”

Section: Enp Hazardsmentioning

confidence: 99%

“…For example, water-dispersible ENP products will not have the same effects as more hydrophobic products on biological organisms. Depending on their solubility, their mobility calculated on the basis of diffusion in a given medium [41] can have implications for possible interactions with cells or extracellular macromolecules. They also may or may not aggregate or form stable colloids.…”

Section: Enp Hazardsmentioning

confidence: 99%

“…The literature is replete with recommendations to confi ne and contain synthetic nanoparticles by process design [66,67], during operations, during maintenance and in situations of accidental spills or potential aerosol formation [68][69][70]. Understanding ENP behaviour should make it possible to determine the most probable entry routes and thereby facilitate rational design, implementation and improvement of monitoring and control measures intended to reduce exposure via these pathways [21,41,46,71].…”

Section: Enp Hazardsmentioning

confidence: 99%

See 3 more Smart Citations

A pilot study towards ranking occupational health risk factors emanating from engineered nanoparticles: review of a decade of literature

Fatisson¹,

Nadeau²,

Hallé³

et al. 2013

Int. J. SAFE

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As benefi cial applications of nanotechnologies in industry and medicine continue to emerge, so do new problems associated with engineered nanoparticle (ENP) production, which so far is going ahead without prior evaluation of its impact on human health and environment. Worker exposure continues to increase while no global consensus on ENP regulation has been reached. Protection of workers requires an approach to risk management properly adapted to the ENP context. Although ENP properties have been studied in depth over the past 10 years, much uncertainty continues to loom over the defi nition of the key parameters. The aim of this review of the literature was to construct a detailed list of known risks associated with ENPs from an occupational health and safety perspective. A hierarchised network of risks was thus revealed, illustrating the complexity of the system in terms of interdependence of elements of risk.

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Section: Enp Hazardsmentioning

confidence: 99%

Section: Enp Hazardsmentioning

confidence: 99%

Section: Enp Hazardsmentioning

confidence: 99%

Section: Enp Hazardsmentioning

confidence: 99%

See 2 more Smart Citations

A pilot study towards ranking occupational health risk factors emanating from engineered nanoparticles: review of a decade of literature

Fatisson¹,

Nadeau²,

Hallé³

et al. 2013

Int. J. SAFE

View full text Add to dashboard Cite

show abstract

“…Recently, Pariselli et al [8] focused on environmentally relevant volatile organic compounds. The biological action 2 Advances in Toxicology of nanoparticles has been extensively studied, as reviewed by Grass et al [9] and Paur et al [10]. Automobile exhausts [11,12] have also been studied recently as well as cigarette smoke [13] or pharmacologically active substances [14].…”

Section: Introductionmentioning

confidence: 99%

Investigations of the Biological Effects of Airborne and Inhalable Substances by Cell-Based In Vitro Methods: Fundamental Improvements to the ALI Concept

Ritter

Knebel

2014

Advances in Toxicology

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The state of the art for cell-based in vitro investigations of airborne and inhalable material is "air-liquid interface" (ALI) technology. Cell lines, primary cells, complex 3D models, or precision-cut lung slices (PCLS) are used to represent the lung or skin by way of an in vitro barrier model. These models have been applied in toxicity or pharmacological testing. However, contrasting with a clear demand for alternative methods, there is still no widely accepted procedure for cell-based in vitro testing of inhalable substances. In the light of this, an analysis was undertaken of common drawbacks of current approaches. Hence, the pivotal improvements aimed at were the cellular exposure environment, overall performance and applicability, operability of online investigations during exposure and routine setup. It resulted in an improved device (P.R.I.T. ExpoCube) based on an "all-in-one-plate" concept including all phases of the experiment (cell culture, exposure, and read-out) and all experimental groups (two test gas groups, controls) in one single commercial multiwell plate. Verification of the concept was demonstrated in a first experimental series using reference substances (formaldehyde, ozone, and clean air). The resulting ALI procedure enables the application of inhalable substances and mixtures under highly effective exposure conditions in routine utilization.

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Analytical Measurements of Nanoparticles in Challenging and Complex Environments

Nelson

Reipa

2017

Metrology and Standardization of Nanotechnology

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Exposure of aerosols and nanoparticle dispersions to in vitro cell cultures: A review on the dose relevance of size, mass, surface and concentration

Cited by 51 publications

References 107 publications

A pilot study towards ranking occupational health risk factors emanating from engineered nanoparticles: review of a decade of literature

A pilot study towards ranking occupational health risk factors emanating from engineered nanoparticles: review of a decade of literature

Investigations of the Biological Effects of Airborne and Inhalable Substances by Cell-Based In Vitro Methods: Fundamental Improvements to the ALI Concept

Analytical Measurements of Nanoparticles in Challenging and Complex Environments

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