Exposure index of methyl isocyanate (MIC) gas disaster and a comprehensive spectrum of cytogenetic analysis after 30 years

Ganguly, Bani Bandana

doi:10.1007/s11356-019-04439-0

Cited by 7 publications

(3 citation statements)

References 95 publications

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“…[ 33 34 ] A pilot follow-up study conducted after 30 years of the tragedy reported stable or clonal rearrangements even after 30 years in increased SCE and decreased replicative index seen immediately after toxic gas exposure. [ 35 ] It also demonstrated a correlation between age, exposure status, and cytogenetic alterations in toxic gas-exposed individuals. However, the cytogenetic alterations observed may not be solely attributed to toxic gas exposure because the effects of confounding variables too contribute to the genetic damage.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of cytogenetic alterations in patients of chronic kidney disease

Samarth,

Tiwari,

Modi

et al. 2023

Indian J Nephrol

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Introduction: In recent years, there has been a rise in chronic kidney disease (CKD), and it has been estimated that by 2040, CKD will be the fifth most common cause of death globally. In addition to diabetes, hypertension, obesity, hyperlipidemia, and nonalcoholic fatty liver disease commonly associated with CKD, exposure to various toxins as a result of pollution or industrial disasters is also discussed as a cause for multi-organ pathology including kidneys. Although few cytogenetic studies were undertaken to assess the genetic damage in survivors of the disaster, no studies are available on the cytogenetic damage of toxic-gas exposed population having CKD. Therefore, the present multi-group cross-sectional study was undertaken to assess the independent role of CKD as well as toxic gas exposure on cytogenetics. Methods: The cytogenetic alterations were evaluated through chromosomal aberration analysis and micronuclei assay. The study included 608 study participants divided into four groups on the basis of history of exposure to the leaked gas and presence or absence of CKD. Results: The results of the study showed no statistically significant difference in cytogenetic damage between gas-exposed and non-exposed patients of CKD, whereas significantly higher cytogenetic damage was observed among gas-exposed participants having CKD compared to gas-exposed participants free from CKD, suggesting that cytogenetic changes could be due to CKD itself. Conclusions: Thus, to conclude, the cytogenetic alterations observed in the study can be partly attributed to the disease itself.

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Section: Discussionmentioning

confidence: 98%

Evaluation of cytogenetic alterations in patients of chronic kidney disease

Samarth,

Tiwari,

Modi

et al. 2023

Indian J Nephrol

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“…3 and 4 of ICMR classi cation (ICMR Technical Report 2008). ICMR-assigned numbers were helpful for identi cation of the subjects for the present study (Ganguly 2019a; Ganguly and Mandal 2017). The participants were counseled and explained about the purpose of the study and possibilities of gain and/or loss from participation, and were also given a summary of the project printed both in English and the local language (Hindi).…”

Section: Methodsmentioning

confidence: 95%

Spectrum of stable and unstable rearrangements in lymphocytic chromosomes investigated in Bhopal population thirty year post MIC-disaster

Ganguly

Mandal

Kadam

2022

Preprint

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Immediate assessment of genetic damage in methyl isocyanate (MIC) gas exposed population in small and heterogeneous samples using diversified study designs and solid-stained metaphases could not depict the actual genetic impact of MIC on accidentally exposed individuals. The outcome of the then large multi-center genetic screening program was not available to the public and scientific community. Also the routine of the regular epidemiological health-survey does not capture the genetic and long-term effect of MIC. Therefore, genetic screening was carried out 30-years post disaster during 2015–2017 with a view to screen the present status of chromosomal consequences in lymphocytic cells. Participants were recruited from moderate (34) and severely (78) exposed, and unexposed (35) cohorts with their informed consent. Analysis of ~ 100 mitotic cells and karyotyping of at least 10–15 and all abnormal metaphases detected structural and numerical alterations, including stable and replicable ones. Clonal abnormalities were detected with monosomal and complex karyotype, trisomy 8, del5q/20q, loss of Y, etc. Among all, X-chromosome was frequently involved in numerical alterations. Structural aberrations appeared higher in the then exposed populations, though abnormalities cannot be linked directly to MIC-exposure 30-year post disaster. Collectively, all rearrangements were markedly higher in the severely exposed population. Altogether, the detected abnormalities appeared random and indicated genomic instability, suggesting follow-up at shorter intervals for the individuals detected with clonal aberrations. G-banding has facilitated recognition of chromosomal involvement and their breakpoints, and classification of structural rearrangements. The present data has been derived from the 30-years post-disaster genetic screening.

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“…However, low birth weight, genetic/developmental/growth disorders and respiratory ailments were thrust areas of research. Few cytogenetic studies were also undertaken to assess genetic damage in gas exposed population (Goswami et al, 1984;Goswami 1986;Goswami et al, 1990;Ghosh et al, 1990;Malla et al, 2011, Senthilkumar et al, 2013Ganguly and Mandal, 2017, Ganguly, 2019. However, no studies are available on cytogenetic damage of toxic gas exposed population having CKD.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of cytogenetic alterations of toxic gas exposed population of Bhopal having chronic kidney disease

Samarth

Tiwari²,

Modi³

et al. 2021

Preprint

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The industrial disaster of Bhopal in 1984 resulted into widespread morbidity and mortality in the vicinity of the industry and required long term surveillance for chronic health effects in those affected by the leakage of gas. Although few cytogenetic studies were undertaken to assess genetic damage in survivors of the disaster, no studies are available on cytogenetic damage of toxic gas exposed population having chronic kidney disease (CKD).Thus, the present study aimed to evaluate cytogenetic alterations in chronic kidney disease patients who wereexposed to leaked gas and to compare it with those who were not exposed to the leaked gas. The cytogenetic alterations were evaluated through chromosomal aberration analysis and micronuclei assay. The study included 608 study participants divided into four groups on the basis of history of exposure to the leaked gas and presence or absence of CKD. The results of the study showed no statistically significant difference in cytogenetic damagebetween gas exposed and non-exposed patients of CKD. However, significantly higher cytogenetic damage was observed among gas exposed participants having CKD as compared to gas exposed participants free from CKD.Thus, to conclude though the cytogenetic alterations were observed in exposed group it cannot be solely attributed to the gas exposure and the role of other confounders must also be studied.

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Exposure index of methyl isocyanate (MIC) gas disaster and a comprehensive spectrum of cytogenetic analysis after 30 years

Cited by 7 publications

References 95 publications

Evaluation of cytogenetic alterations in patients of chronic kidney disease

Evaluation of cytogenetic alterations in patients of chronic kidney disease

Spectrum of stable and unstable rearrangements in lymphocytic chromosomes investigated in Bhopal population thirty year post MIC-disaster

Evaluation of cytogenetic alterations of toxic gas exposed population of Bhopal having chronic kidney disease

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