Exposome in human health: Utopia or wonderland?

Fang, Mingliang; Hu, Ligang; Chen, Da; Lee, Hyewon; Liu, Jianmeng; Lan, Xi; Gong, Jicheng; Wang, Bin

doi:10.1016/j.xinn.2021.100172

Cited by 31 publications

(33 citation statements)

References 10 publications

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“…In the future, using the strategy of exposome to further explore the mechanism between PM 2.5 components and cardiovascular and neurological diseases is highly recommended. 70 …”

Section: Discussionmentioning

confidence: 99%

PM2.5 exposure associated with microbiota gut-brain axis: Multi-omics mechanistic implications from the BAPE study

Fang

Tang

et al. 2022

The Innovation

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“…In the future, using the strategy of exposome to further explore the mechanism between PM 2.5 components and cardiovascular and neurological diseases is highly recommended. 70 …”

Section: Discussionmentioning

confidence: 99%

PM2.5 exposure associated with microbiota gut-brain axis: Multi-omics mechanistic implications from the BAPE study

Fang

Tang

et al. 2022

The Innovation

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“…Third, we did not distinguish the contributions of Th from other toxic pollutants in the air pollution generated from the coal combustion, some other environmental epidemiological methods should be considered in the future to increase the causal inference, e.g. exposomics [ 34 ], repeated measurement analysis [ 35 ], and Bayesian model [ 36 ]. However, our study had three important advantages.…”

Section: Discussionmentioning

confidence: 99%

Thorium and fetal neural tube defects: an epidemiological evidence from large case-control study

et al. 2021

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Background Thorium is ubiquitous in the environment and its relationship with birth defects is still under discussion. This study aimed to investigate the associations of maternal exposure to thorium with risk of neural tube defects (NTDs) by using a case–control study, as well as the relationship between thorium exposure and the indoor air pollution from coal combustion. Methods This study was conducted in 11 local healthcare hospitals during 2003–2007 in Shanxi and Hebei provinces, China. A total of 774 mothers were included as participants who delivering 263 fetuses with NTDs including 123 with anencephaly, 115 with spina bifida, 18 with encephalocele, and 7 other NTD subtypes (cases), and 511 health fetuses without NTDs (controls). Their hair samples were collected as close as to the occipital posterior scalp, of which those grew from 3 months before to 3 months after conception was cut to measure the thorium concentration by inductively coupled plasma-mass spectrometry. Results We found a higher hair thorium concentration in the total NTD cases with 0.901 (0.588–1.382) ng/g hair [median (inter-quartile range)] than that in the controls with a value of 0.621 (0.334–1.058) ng/g hair. Similar results were found for the three concerned NTD subtypes. Maternal hair thorium concentration above its median of the controls was associated with an increased risk of the total NTDs with an adjusted odds ratio of 1.80 [95% confidence interval (CI), 1.23–2.63)] by adjusting for all confounders. There was obvious dose-response relationship between maternal hair thorium concentration and the risk of total NTDs, as well as their two subtypes (i.e. anencephaly and spina bifida). Maternal hair thorium concentration was positive associated with their exposure level to indoor air pollution from coal combustion during cooking. Conclusions Overall, our findings revealed that maternal periconceptional thorium exposure was associated with the risk of NTDs in North China. Reducing the coal usage in the household cooking activities may decrease maternal thorium exposure level. Graphical abstract

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“…Appropriate time-periods for functional exposomics investigations should be defined that enable the study of causal relations between exposure and outcomes ( Fang et al., 2021 ). Yet identification of relevant periods is challenging, especially due to latency between exposure and phenotypic effect ( Balbus et al., 2013 ; Gillman, 2005 ).…”

Section: Functional Exposomics: Concept To Applicationmentioning

confidence: 99%