Exponential–Exponential Cosine Fitting of Blood Pressure Decay Induced by a Long‐Acting Calcium Blocker, Amlodipine, Using Home Blood Pressure Measurement

Mashima, Keiichi; Nakatsu, Takaaki; Murakami, Takashi; Kusachi, Shozo; Tominaga, Yoshihiro; Yamane, Shinnichi; Uesugi, Tadahisa; Mayumi, Eriko; Mitsuda, Takashi; Tsuji, Takao

doi:10.1081/ceh-120019147

Cited by 8 publications

(1 citation statement)

References 12 publications

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“…107 Recently, trends of the antihypertensive effects of drugs have been shown by fitting data to the exponential decay function curve using daily HBPM values. 112 This analysis provides the maximum hypotensive effect and the time to attain the maximum hypotensive effect. 113 Compliance/adherence HBPM can detect the short-term effects of withdrawing antihypertensive drugs (non-compliance).…”

Section: Duration Of Action Of Antihypertensive Drugsmentioning

confidence: 99%

The reason why home blood pressure measurements are preferred over clinic or ambulatory blood pressure in Japan

et al. 2013

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Data regarding ambulatory blood pressure (ABP) or self-BP measurements at home (HBP) have been accumulated. The difference between ABP and HBP is that ABP monitoring (ABPM) provides BP information at many time points on a particular day during unrestricted routine daily activities, whereas HBP provides extensive amounts of BP information obtained under fixed times and conditions over a long period of time; thus, the mean values of HBP are stable, and the reproducibility are high. The high reproducibility of HBP is the rationale for its overall superiority over HBP compared with ABP and clinic BP (CBP). The higher practicality of HBPM over ABPM is definitely recognized. HBPM allows for ongoing disease monitoring by patients and can provide health-care providers with timely clinical data and direct and immediate feedback regarding the diagnosis and treatment of hypertension. HBP is better able than CBP to predict hypertensive target organ damage and a prognosis of cardiovascular disease. Unlike CBPM, HBPM provides BP information in relation to time, that is, BP in the morning, in the evening and at night during sleep. HBPM is an essential tool for the diagnosis of white-coat hypertension and masked hypertension. Day-to-day variability of HBP has clinical significance. HBPM yields minimal alerting effects and placebo effects. HBPM can distinguish small but significant serial changes in BP and is the most practical way to monitor BP in the day-by-day management of hypertension. HBPM improves compliance with antihypertensive medication. The operational threshold of HBP has been established. HBPM is suspected to have a great effect on the medical economy. The superiority of HBPM over ABPM and CBPM is apparent from almost all practical and clinical research perspectives. These characteristics of HBPM indicate that this method is ideal for the diagnosis and treatment of hypertension in daily practice.

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Section: Duration Of Action Of Antihypertensive Drugsmentioning

confidence: 99%

The reason why home blood pressure measurements are preferred over clinic or ambulatory blood pressure in Japan

et al. 2013

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Home (Self) Monitoring of Blood Pressure in Clinical Trials

Stergiou

Ntineri

2016

Blood Pressure Monitoring in Cardiovascular Medicine and Therapeutics

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Randomized trial comparing the velocities of the antihypertensive effects on home blood pressure of candesartan and candesartan with hydrochlorothiazide

et al. 2015

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We aimed to evaluate the hypotensive effect and the time to attain the maximal antihypertensive effect (stabilization time) of 8 mg candesartan/6.25 mg hydrochlorothiazide (HCTZ) combination therapy (combination regimen) and therapy with an increased candesartan dose (12 mg; maximum dose regimen) using home blood pressure (BP) measurements. A prospective, multicenter, open-label, randomized, comparative trial was conducted. Essential hypertensive patients who failed to achieve adequate BP control (systolic BP (SBP) ⩽ 135 mm Hg) on 8 mg candesartan alone were randomized to two groups: the combination regimen (n=103) and the maximum dose regimen (n=103). Home morning SBP reduction at 8 weeks after randomization was 11.4 ± 1.3 mm Hg in the combination regimen and 7.8 ± 1 .2 mm Hg in the maximum dose regimen. The combination regimen provided additional reduction of 4.0 mm Hg (95% confidence interval (CI): 0.8-7.2 mm Hg, P=0.01) in home morning SBP over the maximum dose regimen at 8 weeks after randomization. The maximal antihypertensive effect and stabilization time for home SBP were 9.4 mm Hg and 37.1 days (P<0.0001), respectively, with the combination regimen. The maximum dose regimen decreased home SBP with a very gentle slope, and estimated maximal effect and estimated stabilization time were not significant (P>0.2). The rate of achieving target BP (home morning SBP <135 mm Hg) was significantly higher with the combination regimen than with the maximum dose regimen (52.4 vs. 30.1%, P=0.002). In conclusion, changing from 8 mg candesartan to combination therapy was more effective in reducing home SBP and achieving goal BP more rapidly than increasing the candesartan dose.

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Exponential–Exponential Cosine Fitting of Blood Pressure Decay Induced by a Long‐Acting Calcium Blocker, Amlodipine, Using Home Blood Pressure Measurement

Cited by 8 publications

References 12 publications

The reason why home blood pressure measurements are preferred over clinic or ambulatory blood pressure in Japan

The reason why home blood pressure measurements are preferred over clinic or ambulatory blood pressure in Japan

Home (Self) Monitoring of Blood Pressure in Clinical Trials

Randomized trial comparing the velocities of the antihypertensive effects on home blood pressure of candesartan and candesartan with hydrochlorothiazide

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