“…In order to successfully sequence DNA, the development of nanoscale sensors plays a fundamental role. Previous publications have reported that low-dimensional nanomaterials, including heteronanomaterials, can be promising candidates for selective sensing applications, including the detection of explosives, − the selective sensing of gases, − the detection of environmental pollutants, − and the development of biosensors. − Regarding DNA sequencing, a number of techniques have been established in the past few years, such as optical selective sensing methods using fluorescent labeling of biomolecules and Sanger sequencing detection approaches (chain termination) for regions of DNA of approximately 900 nucleobase pairs in length. However, such methods are rather expensive and time-consuming. ,− On the other hand, a variety of alternative and promising strategies based on nanoscale elements have been developed, such as the use of single molecules, which show the possibility of accurately interrogating the nucleobase sequence, ,− or the use of solid-state nanogaps/nanopores. ,,− However, faster, less expensive, and label-free approaches for discriminating small molecules such as the DNA nucleotides are still needed and can be considered highly desired targets of current technology. ,, …”