Exploring troublesome symptom and problems experienced by cancer patients undergoing chemotherapy

Singh, Harminder; Singh, Rohit; Singh, Baltej; Tiwana, Kanwardeep Kaur

doi:10.5530/jyp.2016.3.9

Cited by 4 publications

(4 citation statements)

References 9 publications

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“…This contradicts a Study by Singh et al . [ 10 ] in India, showing females at higher risk for DRPs; 148 (52.3%). The variation between results could be due to the smaller sample size in our study population.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of supportive care management outcomes in cancer chemotherapy: A prospective observational study in a tertiary care teaching hospital in South India

Reji

Kumar

Nair

et al. 2018

Indian J Palliat Care

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Aims:Evaluation of supportive care management of cancer patients experiencing drug-related problems (DRPs) is a challenge because it might increase the cost due to additional therapy. The main objectives of this study were to estimate chemotherapy-associated drug-related hospital admissions in the department of medical oncology and to estimate the cost of managing chemotherapy-associated DRPs.Settings and Design:This study is a prospective observational study.Subjects and Methods:Patients with chemotherapy-related DRPs were prospectively identified from the patient's medical records. The contribution of DRPs and cost incurred due to each hospitalization was assessed.Statistical Analysis Used:Data were analyzed using SPSS® 20.0 version.Results:Out of 55 patients analyzed for DRPs, 25 (45.5%) patients in the age group of 51–60 years experienced DRPs most frequently. Most commonly occurring DRP was adverse drug reactions 42 (76.4%), which were more frequent in females. DRPs were maximum with alkylating agents 15 (27.3%) and the least with hormonal agents 1 (1.8%). The mean length of hospitalization was 9.6 ± 6.5 days. The total direct medical cost was Rs. 31,540 ± 42,476, of which medicine cost accounted for Rs. 16,550 ± 25,404, constituting a major share of the total medical costs.Conclusions:Pharmacists can provide better patient care by identifying and preventing DRPs and reducing drug-related morbidity and mortality.

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Section: Discussionmentioning

confidence: 99%

“…A similar result was observed in a study done in India by Singh et al . [ 10 ] where DRPs were caused mostly by alkylating agents (40%). Less than three chemotherapeutic agents were prescribed in 14 (25.5%) patients and more than three chemotherapeutic agents were prescribed in 41 (74.5%).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of supportive care management outcomes in cancer chemotherapy: A prospective observational study in a tertiary care teaching hospital in South India

Reji

Kumar

Nair

et al. 2018

Indian J Palliat Care

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“…Kejadian toksisitas pada suatu obat dapat memengaruhi pemulihan pasien serta berdampak terhadap besar pembiayaan pada pengobatan pasien. 21 Pada percobaan NEJ002, gefitinib memiliki perbaikan gejala yang cepat dan toksistas yang rendah. Efek samping yang paling umum dilaporkan yaitu ruam dan diare.…”

Section: Pembahasanunclassified

Efikasi Afatinib dan Gefitinib pada Pasien Non-small Cell Lung Cancer EGFR Mutasi Positif: Tinjauan Sistematis

Sari

Andayani²,

Endarti

et al. 2019

ijcp

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Tyrosine kinase inhibitors (TKIs) telah direkomendasikan oleh National Comprehensive Cancer Network (NCCN) sebagai terapi lini pertama pada pasien non-small cell lung cancer (NSCLC) dengan mutasi EGFR, yaitu gefitinib (generasi pertama) dan afatinib (generasi kedua). Beberapa penelitian telah dilakukan terkait efikasi golongan TKIs ini, namun masih sedikit yang melakukan tinjauan sistematis (systematic review) secara khusus pada afatinib dan gefitinib. Systematic review ini bertujuan untuk memberikan gambaran secara komprehensif terkait efikasi afatinib dan gefitinib sebagai terapi lini pertama. Database yang digunakan untuk mengidentifikasi studi yang relevan yaitu Science Direct, PubMed dan Google Scholar. Penelitian ini terbatas pada penelitian randomized control trial, penggunaan afatinib dan gefitinib sebagai terapi lini pertama, penggunaan afatinib dan gefitinib secara monoterapi serta artikel yang menggunakan bahasa Inggris. Penelusuran berbasis data elektronik menghasilkan 2089 artikel; 48 artikel yang sudah sesuai dengan judul dan abstrak, namun hanya 8 artikel yang sesuai dengan inklusi yang ingin ditinjau. Secara umum efikasi afatinib dan gefitinib lebih unggul dibandingkan kemoterapi berbasis platinum, dapat dilihat dari progression free survival dari kedua obat ini yang lebih lama dibandingkan kemoterapi berbasis platinum. Walaupun nilai overall survival-nya tidak begitu lebih baik, afatinib dapat memperlambat perkembangan tumor lebih baik dibandingkan gefitinib. Efek samping yang sering terjadi pada afatinib dan gefitinib yaitu ruam dan diare, sedangkan neutropenia, mual, anemia sering terjadi pada penggunaan kemoterapi berbasis platinum. Afatinib dan gefitinib memberikan efikasi yang lebih baik dibandingkan kemoterapi berbasis platinum, namun afatinib memiliki efikasi yang lebih unggul dibandingkan gefitinib dalam pengobatan lini pertama pada pasien NSCLC dengan mutasi EGFR.

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“…5 Patients with complex drug therapy are at high risk for MEs and drug related problems. 6 The best way to reduce the MEs is implementing the computerized provider order entry with clinical decision support system. 7 MEs during patient discharge can cause harm; this is mainly due to handwritten discharge orders, and usually these will be prepared by the junior doctors.…”

Section: Introductionmentioning

confidence: 99%

Impact of Electronic Prescribing System on Prescribing Error Rate at Patients’ Transition of Care: An Interventional Study

Yugandhar¹,

Shewade²,

Dharanipragada³

et al. 2017

JYP

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Objective:To estimate the prevalence of prescribing errors before and after implementing electronic discharge prescription system in the wards of General Surgery in a tertiary care hospital in India. Methodology: Patients discharged from General Surgery wards with a prescription containing atleast one drug were selected. Discharge prescriptions were collected before and after implementing the electronic prescribing system. Patients' demographic details like age, gender, diagnosis and number days of hospital stay were recorded in the specially designed case record form. Discharge orders were scanned to evaluate the prescribing errors in these orders. Results: A total of 1045 handwritten and 1152 electronic discharge summaries were collected, of which 76.7% and 76.2% were of <60 years aged patients, 64.3% and 63.5% of male gender respectively in both the groups. Average number of drugs prescribed per prescription was 3.5 and 4.1 before and after intervention; error rate was 33% and 8.4% of drugs prescribed respectively, 46.3% of prescriptions were of illegible handwriting. The intervention of an electronic prescribing system has reduced 75% of prescribing errors. Handwritten prescriptions had 5.5 higher odds of having prescribing errors (OR 5.5, 95% CI 4.6-6.1). Conclusion: The electronic prescribing system has a high impact in reducing prescribing errors in discharge prescriptions. Handwritten prescriptions had 5.5-times odds of higher risk for prescribing errors. Increase in age, number of drugs prescribed and length of hospital stay were major predictors of prescribing errors.

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Exploring troublesome symptom and problems experienced by cancer patients undergoing chemotherapy

Cited by 4 publications

References 9 publications

Evaluation of supportive care management outcomes in cancer chemotherapy: A prospective observational study in a tertiary care teaching hospital in South India

Evaluation of supportive care management outcomes in cancer chemotherapy: A prospective observational study in a tertiary care teaching hospital in South India

Efikasi Afatinib dan Gefitinib pada Pasien Non-small Cell Lung Cancer EGFR Mutasi Positif: Tinjauan Sistematis

Impact of Electronic Prescribing System on Prescribing Error Rate at Patients’ Transition of Care: An Interventional Study

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