Exploring the role of inflammation in the malignant transformation of low-grade gliomas

Michelson, Nicole; Rincón-Torroella, Jordina; Quiñones‐Hinojosa, Alfredo; Greenfield, Jeffrey P.

doi:10.1016/j.jneuroim.2016.05.019

Cited by 52 publications

(38 citation statements)

References 88 publications

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“…Accumulating evidence has shown that low‐grade gliomas have the potential to evolve into high‐grade gliomas, and this process can be triggered by factors such as inflammation in the tumor microenvironment and somatic mutation . Malignant transformation of low‐grade gliomas threatens the prognosis of patients seriously.…”

Section: Discussionmentioning

confidence: 99%

Nucleolar and spindle‐associated protein 1 is a tumor grade correlated prognosis marker for glioma patients

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Nucleolar and spindle‐associated protein 1 is a tumor grade correlated prognosis marker for glioma patients

et al. 2018

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“…In addition, adipose inflammation and epithelial-mesenchymal transition are involved in inflammation induced tumor initiation and progression [ 51 , 52 ]. Tumors can also harness the inflammatory responses via various inflammatory mediators to survive and proliferate, and even fostering a tumor milieu ripe for progression and metastasis [ 53 ]. Now more evidences show that the presence of systemic inflammation is correlated with poorer survival in several cancers [ 54 - 57 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of neutrophil-to-lymphocyte ratio in urothelial carcinoma of the upper urinary tract and bladder: a systematic review and meta-analysis

Tang

et al. 2016

Oncotarget

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The neutrophil-to-lymphocyte ratio (NLR) is an inflammation marker that has prognostic value for various tumors, but its prognostic value in urothelial carcinoma (UC) remains controversial. This meta-analysis investigated the prognostic value of NLR in UC. A systematic search was performed on PubMed, ISI Web of Science, and Embase for studies focusing on the association between NLR and clinical features or prognosis of UC and published until November 2016. Prognostic outcomes and clinical features were collected and analyzed. A total of 11,538 patients from 32 studies were included in the meta-analysis. Increased pretreatment NLR predicted poor overall survival (hazard ratio [HR] = 1.72, 95% confidence interval [CI] = 1.45–2.05), progression free survival (HR = 1.68, 95% CI = 1.44–1.96), and cancer specific survival (HR = 1.64, 95% CI = 1.39–1.93) in all the patients. The increased pretreatment NLR was correlated with increased lymphovascular invasion (HR = 1.29, 95% CI = 1.17–1.43), high tumor T stage (HR = 1.25, 95% CI = 1.12–1.39), and tumor grade (HR = 1.07, 95% CI = 1.01–1.14) but not with lymph node involvement, carcinoma in situ, multifocality, or positive margin. Our meta-analysis indicated that NLR could predict the prognosis for UC and was associated with UC progression in terms of lymphovascular invasion, tumor T stage, and tumor grade.

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“…Previously, due to the presence of the blood‐brain barrier (BBB) and the absence of a classical lymphatic drainage system, the theory that brain was an immune‐privilege organ was widely accepted . Nowadays, inflammation has been identified to be a hallmark of cancer and the critical role of inflammation components in glioma was a well‐established concept . Macrophages, T lymphocytes, and neutrophils were the important infiltrative inflammation cells in glioma microenvironment which could suppress or promote tumor progression …”

Section: Introductionmentioning

confidence: 99%

Peripheral blood test provides a practical method for glioma evaluation and prognosis prediction

et al. 2019

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Summary Objective To investigate the relationship between tumor characteristics and the preoperative counts of immune cells in peripheral blood test in glioma patients. Methods We included 260 WHO grades II‐IV patients who had preoperative peripheral blood test result from Sanbo hospital as training set. The 66 patients from Tiantan hospital was obtained for validation. RNA sequencing data from CGGA and TCGA datasets were used to evaluate the features of neutrophil subtype and lymphocyte subtype in glioma. Results We revealed that the count of preoperative lymphocytes, eosinophils and neutrophils were associated with glioma grades. Neutrophil‐to‐lymphocyte ratio (NLR) <3.2 was associated with better prognosis, whereas increased NLR was strongly corresponding with a poor prognosis. Lymphocyte type glioma patients demonstrated a positive correlation with isocitrate dehydrogenase (IDH) mutation and lower grade. IDH mutant glioma contained a higher proportion of tumor‐infiltrating lymphocytes than IDH wild‐type glioma. The immune subtype (neutrophil subtype and lymphocyte subtype) was an independent prognostic factor in glioma. Conclusion Our data demonstrated that NLR was an important prognostic factor in glioma. We classified that the immune subtype of glioma may contribute to a better understanding of disease pathogenesis and lead to the identification of new therapeutic targets for glioma patients.

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Exploring the role of inflammation in the malignant transformation of low-grade gliomas

Cited by 52 publications

References 88 publications

Nucleolar and spindle‐associated protein 1 is a tumor grade correlated prognosis marker for glioma patients

Nucleolar and spindle‐associated protein 1 is a tumor grade correlated prognosis marker for glioma patients

Prognostic value of neutrophil-to-lymphocyte ratio in urothelial carcinoma of the upper urinary tract and bladder: a systematic review and meta-analysis

Peripheral blood test provides a practical method for glioma evaluation and prognosis prediction

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