Exploring the Role of Gut Microbiome in Colon Cancer

Chattopadhyay, Indranil; Dhar, Ruby; Pethusamy, Karthikeyan; Seethy, Ashikh; Srivastava, Tryambak; Sah, Ramkishor; Sharma, Jyoti; Karmakar, Subhradip

doi:10.1007/s12010-021-03498-9

Cited by 85 publications

(88 citation statements)

References 128 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is likely due to the limited number of samples. Previous studies have suggested that dietary changes affect the composition of intestinal microbiota, which is associated with fragility, nutritional status, and various diseases [35][36][37][38][39][40]. As such, the effect of dietary changes on the intestinal microbiota in regard to CRC carcinogenesis is also a topic for future study.…”

Section: Discussionmentioning

confidence: 97%

Colorectal Cancer Patients Have Four Specific Bacterial Species in Oral and Gut Microbiota in Common—A Metagenomic Comparison with Healthy Subjects

Uchino

Goto

Konishi

et al. 2021

Cancers

View full text Add to dashboard Cite

Oral microbiota is reportedly associated with gut microbiota and influences colorectal cancer (CRC) progression; however, the details remain unclear. This study aimed to evaluate the role of oral microbiota in CRC progression. Fifty-two patients with CRC and 51 healthy controls were included. Saliva and stool samples were collected, and microbiota were evaluated using 16S rRNA analysis and next-generation sequencing. Comparative analysis was performed on both groups. Linear discriminant analysis effect size (LEfSe) revealed the presence of indigenous oral bacteria, such as Peptostreptococcus, Streptococcus, and Solobacterium spp., at a significantly higher relative abundance in saliva and stool samples of CRC patients compared with controls. Next, CRC patients were divided into early stage (Stage I, II; n = 26; 50%) and advanced stage (Stage III, IV; n = 26; 50%) disease. LEfSe revealed that S. moorei was present at a significantly higher relative abundance in the advanced-stage group compared with the early-stage group, again consistent for both saliva and stool samples. Among bacterial species with significantly higher relative abundance in CRC patients, P. stomatis, S. anginosus, S. koreensis, and S. moorei originated from the oral cavity, suggesting indigenous oral bacteria may have promoted initiation of CRC carcinogenesis. Furthermore, S. moorei may influence CRC progression.

show abstract

Section: Discussionmentioning

confidence: 97%

Colorectal Cancer Patients Have Four Specific Bacterial Species in Oral and Gut Microbiota in Common—A Metagenomic Comparison with Healthy Subjects

Uchino

Goto

Konishi

et al. 2021

Cancers

View full text Add to dashboard Cite

show abstract

“…The expansion of this field has been allowed by the improved rearing of GF mice and rats, with multiplication of the GF facilities around the world. It has also forwarded the knowledge on the commensal microflora composition and its interconnection with the carcinogenesis processes, especially of the colon [13,17,18]. Spontaneous tumors appear with aging and, in GF animals, with higher frequency when they are over one-year-old.…”

Section: Discussionmentioning

confidence: 99%

“…The presence of commensal bacteria in the gut maintains a continuous stimulus sustaining a constant activation of the immunity in the mucosa, and, contemporarily, it has metabolic effects by the elaboration of the bile and food components as well [8][9][10]. Therefore, the absence of such immunological stimulation and metabolic interactions in GF animals makes them a unique tool to study the influence that bacteria can have in the development of colorectal cancer (CRC) [11][12][13]. Thus, since the beginning of GF animal production, many studies have been done using this model to demonstrate that certain types of microbiota can activate inflammatory and oncogenic pathways and promote intestinal tumorigenesis leading to CRC [11,12,[14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

“…Thus, since the beginning of GF animal production, many studies have been done using this model to demonstrate that certain types of microbiota can activate inflammatory and oncogenic pathways and promote intestinal tumorigenesis leading to CRC [11,12,[14][15][16][17]. Dietary habits can affect the composition of intestinal microbiota leading to dysbiosis and consequent pathological changes in the colon mucosa [13,[18][19][20]. As such, dietary habits, and associated microbiota, represent an essential environmental factor implied in CRC development.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Spontaneous and Induced Tumors in Germ-Free Animals: A General Review

et al. 2021

View full text Add to dashboard Cite

Cancer, bacteria, and immunity relationships are much-debated topics in the last decade. Microbiome′s importance for metabolic and immunologic modulation of the organism adaptation and responses has become progressively evident, and models to study these relationships, especially about carcinogenesis, have acquired primary importance. The availability of germ-free (GF) animals, i.e., animals born and maintained under completely sterile conditions avoiding the microbiome development offers a unique tool to investigate the role that bacteria can have in carcinogenesis and tumor development. The comparison between GF animals with the conventional (CV) counterpart with microbiome can help to evidence conditions and mechanisms directly involving bacterial activities in the modulation of carcinogenesis processes. Here, we review the literature about spontaneous cancer and cancer modeling in GF animals since the early studies, trying to offer a practical overview on the argument.

show abstract

“…As an example, the consumption of probiotics like Lactobacillus and Bifidobacterium can improve the secretion of the SCFA by the epithelium limiting angiogenesis and therefore the growth of CRC. 110 Hence, probiotics could decrease the abundance of Bifidobacterium, Clostridium, Faecalibacterium , and Roseburia bacteria observed in CRC patients and leverage the colonization of commensal bacteria such as E. coli, E. faecalis, F. nucleatum , and S. gallolyticus . In 2018, Rothschild et al looked at the association between the gut microbiota and environmental and genetic factors and found that the gut microbiota was predominantly (20% of the variance in microbiome β-diversity) established and influenced by environmental factors like diet or lifestyle rather than genetically heritable (only 1.9%).…”

Section: The Intestinal Microenvironment Linked To Crcmentioning

confidence: 99%

“Driver-passenger” bacteria and their metabolites in the pathogenesis of colorectal cancer

Avril

DePaolo

2021

Gut Microbes

View full text Add to dashboard Cite

Colorectal cancer (CRC) is a significant public health problem accounting for about 10% of all new cancer cases globally. Though genetic and epigenetic factors influence CRC, the gut microbiota acts as a significant component of the disease's etiology. Further research is still needed to clarify the specific roles and identify more bacteria related to CRC development. This review aims to provide an overview of the "driver-passenger" model of CRC. The colonization and active invasion of the "driver(s)" bacteria cause damages allowing other commensals, known as "passengers," or their byproducts, i.e., metabolites, to pass through the epithelium . This review will not only focus on the species of bacteria implicated in this model but also on their biological functions implicated in the occurrence of CRC, such as forming biofilms, mucus, penetration and production of enterotoxins and genotoxins.

show abstract

Exploring the Role of Gut Microbiome in Colon Cancer

Cited by 85 publications

References 128 publications

Colorectal Cancer Patients Have Four Specific Bacterial Species in Oral and Gut Microbiota in Common—A Metagenomic Comparison with Healthy Subjects

Colorectal Cancer Patients Have Four Specific Bacterial Species in Oral and Gut Microbiota in Common—A Metagenomic Comparison with Healthy Subjects

Spontaneous and Induced Tumors in Germ-Free Animals: A General Review

“Driver-passenger” bacteria and their metabolites in the pathogenesis of colorectal cancer

Contact Info

Product

Resources

About