“Driver-passenger” bacteria and their metabolites in the pathogenesis of colorectal cancer

Avril, Marion; DePaolo, R. William

doi:10.1080/19490976.2021.1941710

Cited by 39 publications

(30 citation statements)

References 113 publications

(164 reference statements)

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“…The model suggests that driver bacteria promote the colonization of passenger bacteria by altering the intestinal microenvironment, and differences in the types of driver and passenger bacteria are found at different stages of CRC development. Since then, several studies based on the "driver‐passenger" model have reached consistent conclusions 9,41,42 . Wang Y et al sequenced CRC cancer and paraneoplastic tissues and identified 4 genera and 2 families of potential driver bacteria and 14 genera and 14 families of potential passenger bacteria, suggesting their potential role as predictive markers for the early diagnosis of CRC 9 …”

Section: Intestinal Mucosal Tissue Microbiome and Early Detection Of Crcmentioning

confidence: 89%

“…Since then, several studies based on the "driver‐passenger" model have reached consistent conclusions. 9 , 41 , 42 Wang Y et al sequenced CRC cancer and paraneoplastic tissues and identified 4 genera and 2 families of potential driver bacteria and 14 genera and 14 families of potential passenger bacteria, suggesting their potential role as predictive markers for the early diagnosis of CRC. 9 …”

Section: Intestinal Mucosal Tissue Microbiome and Early Detection Of Crcmentioning

confidence: 99%

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Gut microbiome: New biomarkers in early screening of colorectal cancer

Zhou

Yang

Sun

et al. 2022

Clinical Laboratory Analysis

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Background Certain “star intestinal bacteria” have been found to act as a contributor to the development of colorectal cancer (CRC). Besides, given that the gut microbiome can be detected in a diverse range of samples (stool, tissue, blood, etc), it is categorized into fecal microbiome, blood microbiome, and tissue microbiome. Methods To provide an overview of the recent research progress, this review summarizes the characteristics of the gut microbiome in different samples at each stage of CRC and their screening efficiency. Results The screening models constructed from different sample microbiomes (healthy/colorectal adenoma, healthy/CRC, and colorectal adenoma/CRC) have both strengths and constraints in terms of biomarker reproducibility and area under the receiver‐operating characteristic curve (AUC) of the screening models. Many bacteria, such as Bifidobacteria, Fusobacterium nucleatum (F. n), Geotrichum candidum, Porphyromonas asaccharolytica, Escherichia coli, Rhodococcus, Anaerostipes caccae, Enhydrobacter, Lachnoclostridiumsp. m3, Bacteroides clarus, Clostridium hathewayi, Ruminococcaceae, Bacteroides thetaiotaomicron, Culinariside, and enterotoxigenic Bacteroides fragilis (ETBF), show favorable diagnostic efficacy in early screening of colorectal cancer. Conclusions This review highlights stool, blood, tissue, and bowel fluid are the main sample sources for biomarkers, each with its own advantages and limitations. Moreover, other samples such as extracellular vesicles and biofilms also should been deserved further attention.

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Section: Intestinal Mucosal Tissue Microbiome and Early Detection Of Crcmentioning

confidence: 89%

Section: Intestinal Mucosal Tissue Microbiome and Early Detection Of Crcmentioning

confidence: 99%

Gut microbiome: New biomarkers in early screening of colorectal cancer

Zhou

Yang

Sun

et al. 2022

Clinical Laboratory Analysis

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“…ETBF toxin is coded by the bft gene and is highly correlated with diarrhea in humans[ 53 , 54 ]. ETBF can cleave E-cadherin in the epithelial cells, allowing bacterial translocation[ 55 , 56 ]. ETBF induces an IL-17-mediated immune response with the infiltration of lymphocytes and neutrophils and damages the DNA via the formation of microadenoma[ 4 , 53 , 54 ].…”

Section: To the Editormentioning

confidence: 99%

“…A recent manuscript by Avril and DePaolo[ 56 ], identified that the co-colonization of ETBF and Escherichia coli strains, harboring the pks island, promotes the development of intestinal cancer. ETBF promotes the degradation of the intestinal mucus and induction of IL-17-mediated inflammation by the host’s immune cells.…”

Section: To the Editormentioning

confidence: 99%

Intestinal inflammation and the microbiota: Beyond diversity

Alberca¹,

Cardoso²,

Solis-Castro³

et al. 2022

WJG

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The recent manuscript entitled “Relationship between clinical features and intestinal microbiota in Chinese patients with ulcerative colitis” reported a difference in the intestinal microbiota of patients with ulcerative colitis according to the severity of the colitis. The influence of the intestinal microbiota on the development and progress of gastrointestinal disorders is well established. Besides the diversity in the microbiome, the presence of virulence factors and toxins by commensal bacteria may affect an extensive variety of cellular processes, contributing to the induction of a proinflammatory environment.

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“…It can metabolize the indigestible components of food, synthesize nutrients for epithelial regeneration, and modulate the immune response to maintain mucosal integrity by protecting against harmful environmental and endogenous toxic stimuli [11][12][13][14] .The initiation and progression of CRC are related to complex biological pathways involving multiple genetic and epigenetic alterations [15][16][17] . Many reports have shown that dysbiosis is closely associated with the initiation and progression of CRC and that the gut microbiome can be a candidate marker for early detection of CRC [18][19][20][21][22][23][24][25] . Therefore, modulation of the gut microbiome has been attempted as an adjunctive therapeutic strategy for CRC, such as increasing the sensitivity of immune checkpoint inhibitors in advanced and metastatic CRC [26][27][28] .…”

Section: Introductionmentioning

confidence: 99%

Crosstalk between mucosal microbiota, host gene expression, and sociomedical factors in the progression of colorectal cancer

Kim

Gim

Lee

et al. 2022

Preprint

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Various omics-based biomarkers related to the occurrence, progression, and prognosis of colorectal cancer (CRC) have been identified. In this study, we attempted to identify gut microbiome-based biomarkers and detect their association with host gene expression in the initiation and progression of CRC by integrating analysis of the gut mucosal metagenome, RNA sequencing, and sociomedical factors. We performed metagenome and RNA sequencing on colonic mucosa samples from 13 patients with advanced CRC (ACRC), 10 patients with high-risk adenoma (HRA), and 7 normal control (NC) individuals. All participants completed a questionnaire on sociomedical factors. The interaction and correlation between changes in the microbiome and gene expression were assessed using bioinformatic analysis. When comparing HRA and NC samples, which can be considered to represent the process of tumor initiation, 28 genes and five microbiome species were analyzed with correlation plots. When comparing ACRC and HRA samples, which can be considered to represent the progression of CRC, seven bacterial species and 21 genes were analyzed. When comparing ACRC and NC samples, 16 genes and five bacterial species were analyzed, and four correlation plots were generated. A network visualizing the relationship between bacterial and host gene expression in the initiation and progression of CRC indicated that Clostridium spiroforme and Tyzzerella nexilis were hub bacteria in the development and progression of CRC. Our study revealed the interactions of and correlation between the colonic mucosal microbiome and host gene expression to identify potential roles of the microbiome in the initiation and progression of CRC. Our results provide gut microbiome-based biomarkers that may be potential diagnostic markers and therapeutic targets in patients with CRC.

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“Driver-passenger” bacteria and their metabolites in the pathogenesis of colorectal cancer

Cited by 39 publications

References 113 publications

Gut microbiome: New biomarkers in early screening of colorectal cancer

Gut microbiome: New biomarkers in early screening of colorectal cancer

Intestinal inflammation and the microbiota: Beyond diversity

Crosstalk between mucosal microbiota, host gene expression, and sociomedical factors in the progression of colorectal cancer

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