Exploring the relationship between vitamin D and mania: correlations between serum vitamin D levels and disease activity

Altunsoy, Neslihan; Yüksel, Rabia Nazik; Yirün, Merve Cingi; Kılıçarslan, Ayşegül; Aydemir, Çiğdem

doi:10.1080/08039488.2018.1424238

Cited by 28 publications

(22 citation statements)

References 26 publications

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“…Next control laboratory tests performed one month after the initial hospitalization showed a re-increase of these indicators, which could be attributed to the continuous use of psychoactive substances. Additionally, the patient was confirmed with significant hypovitaminosis D (9.99 ng / ml), which, according to the literature, may be associated with mood disorders, depression and bipolar disorder [ 21 , 22 ]. In addition, low vitamin D3 levels are a predictor of suicide attempts.…”

Section: Discussionmentioning

confidence: 98%

Diagnostic difficulties in the diagnosis of high acute-phase proteins levels in a teenage drug addicted female patient

et al. 2022

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Background Youth drug addiction is a significant social and health problem. Symptoms of the disease include a number of neurological, gastrointestinal and cardiovascular disorders. Possible hormonal disorders and dysregulation of the immune system could also occur. Case presentation We describe a case of a teenage patient with multiple diseases such as esophagitis, allergic disease, and numerous behavioral disorders leading to: self-injury of the body, suicide attempts by drugs overdosing, and experimentation with various psychoactive substances (morphine, amphetamine, methamphetamine, codeine). She was also diagnosed with bipolar disorder. A few hours before the admission to the ward, the patient had an intravenous injection of drugs. Toxicological tests confirmed the presence of amphetamine, ecstasy and opioids in the blood and urine. Laboratory tests revealed extremely increased inflammatory parameters, leucopenia, increased levels of IgG, IgA and IgE (total) immunoglobulins, low concentration of vitamin D. Bacteriological examinations were negative. General condition of the patient got better very quickly, antibiotic therapy was abandoned on the 4th day. It was concluded that the cause of the elevated concentration of acute-phase proteins was most likely caused by intoxication with psychoactive drugs. Conclusions The discussed case shows the difficulties of differential diagnosis in a teenage patient struggling with many diseases, who has been abusing drugs for several years. Increased inflammatory parameters in the form of an raised PCT, CRP, NLR, PLR values may be caused by many factors. In adolescents who frequently experiment with psychoactive substances, such cause of these disturbances should also be taken into account.

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Section: Discussionmentioning

confidence: 98%

Diagnostic difficulties in the diagnosis of high acute-phase proteins levels in a teenage drug addicted female patient

et al. 2022

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“…Cependant, Altunsoy et al ont souligné que la dose neuroprotectrice de vitamine D n'était pas encore connue, et ce d'autant plus que le SNC serait capable de convertir la 25OHD en calcitriol et que le taux sérique de 25OHD pourrait retentir sur la synthèse de vitamine D active au niveau du cerveau. 39 Ceci soulève la question de l'étendue des effets positifs de la 25OHD sur le SNC.…”

Section: Discussionunclassified

Vulnérabilité au Trouble Bipolaire: La Piste de la Vitamine D

et al. 2019

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Objectifs : L’étiopathogénie du trouble bipolaire (TB) demeure non encore bien élucidée. Récemment, il a été prouvé que la 25-hydroxy-vitamine D(25OHD) a un rôle anti-inflammatoire et neuroprotecteur. Nos objectifs étaient de mesurer les concentrations plasmatiques de la 25OHD chez des patients atteints de TB en décompensation aigue et de les comparer à celles de patients souffrant de schizophrénie (SCZ) ou de trouble schizo-affectif (TSA) et à celles de témoins sains Méthodes : Il s’agissait d’une étude transversale de type cas-témoins qui a inclus des patients de sexe masculin hospitalisés pour une décompensation de leur maladie et chez qui les diagnostics de TB, SCZ, ou de TSA ont été retenus selon les critères du (DSM-5). Le groupe témoin a été constitué de sujets sains non apparentés, appariés selon l’age et le sexe. Résultats : La concentration de la 25OHD était significativement plus élevée uniquement chez les patients atteints de TB par rapport aux témoins. la 25OHD était aussi corrélée positivement à l’échelle PANSS (r = 0.282, p < 0.001) et aux différents scores de l’échelle MOCA (r = 0.326, p = 0.006) ainsi qu’aux dimensions concernant la capacité d’abstraction, d’attention et la mémoire . A l’analyse multivariée, la décompensation aigue du TB était liée de manière indépendante à l’élévation de la 25OHD plasmatique (p = 0.012; OR = 1.157, [1.032 -1.297]). Conclusion : Notre étude a montré que la décompensation aigue des TB était associée à une élévation de la synthèse de la 25OHD plasmatique. Toutefois, la pertinence du dosage de la vitamine D comme biomarqueur de cette maladie mérite d’être vérifiée par d’autres études.

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“…Altunsoy et al [ 25 ], reported the serum levels of 25 (OH) vitamin D in healthy adults with a mean age of 37.58 years (23 male, 17 female) as 22.31 ± 8.8 ng/ml. Another study found that the median value of 25 (OH) vitamin D in 50 healthy adults with a mean age of 53.44 ± 8.4 22 years as 22 (6–40) ng/ml [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D levels in patients with recurrent aphthous stomatitis

Öztekin

2018

BMC Oral Health

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BackgroundLower serum vitamin D levels, a major public health problem worldwide, has been found to be associated with various infectious diseases, cancers, autoimmune and dermatological diseases. The serum levels of vitamin D in patients with recurrent aphthous stomatitis are not clear. We investigated the vitamin D levels in patients with recurrent aphthous stomatitis.MethodsForty patients with recurrent aphthous stomatitis (Group I) and 70 healthy controls (Group II) included in the study. The characteristics of aphthous lesions (duration of disease and remission, frequency, diameter and number of the lesions) and demographics of the participants were recorded. Serum 25-hydroxycholecalciferol levels were measured using electrochemiluminescence binding method.ResultsThere was no statistically significant difference between the groups in terms of age (p = 0.06) and sex (p = 0.4). Other baseline characteristics were not significantly different between the groups (p > 0.05 for all). The mean diameter of aphthous lesions was 0.5 (0.4–0.6) cm and the mean number of lesions was 2.2 ± 1.5. Serum vitamin D levels were 11 ± 7.04 ng/ml in Group I and 16.4 ± 10.19 ng/ml in Group II. Serum vitamin D levels were significantly lower in patients with recurrent aphthous stomatitis (p = 0.004).ConclusionsThe present study showed lower vitamin D levels in patients with recurrent aphthous stomatitis compared to healthy controls.

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Exploring the relationship between vitamin D and mania: correlations between serum vitamin D levels and disease activity

Cited by 28 publications

References 26 publications

Diagnostic difficulties in the diagnosis of high acute-phase proteins levels in a teenage drug addicted female patient

Diagnostic difficulties in the diagnosis of high acute-phase proteins levels in a teenage drug addicted female patient

Vulnérabilité au Trouble Bipolaire: La Piste de la Vitamine D

Vitamin D levels in patients with recurrent aphthous stomatitis

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