Exploring the proximate composition, antioxidant, anti-Parkinson's and anti-inflammatory potential of two neglected and underutilized Mucuna species from India

Rane, Manali R.; Suryawanshi, Sachin R.; Patil, Ravishankar; Aware, Chetan; Jadhav, Rahul R.; Gaikwad, Swaroopsingh; Singh, Prem Prakash; Yadav, S. R.; Bapat, Vishwas A.; Gurav, Rajaram V.

doi:10.1016/j.sajb.2019.04.030

Cited by 23 publications

(17 citation statements)

References 34 publications

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“…Mucuna pruriens L. (Family: Fabaceae) (MP) have immense medicinal properties specifically due to high L-DOPA (L-3,4dihydroxyphenylalanine) content and its role in parkinsons disease (Rane et al, 2019). MP belonging to family Fabaceae which preferably found in tropical and subtropical regions of world.…”

Section: Nardostachys Jatamansimentioning

confidence: 99%

Comparative evaluation of Nardostachys jatamansi and Mucuna pruriens as neuroprotective in Parkinson's disease

Giri¹,

Bhalke²,

Prakash³

et al. 2020

Asian J Pharm Pharmacol

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Objective: In the present study, comparative antioxidant and antiparkinsonian effect of hydroalcoholic extract of Nardostachys jatamansiMucuna pruriens (HENJ) and (HEMP) was studied. The Materials and methods: antiparkinsonian activity was evaluated by using haloperidol induced catalepsy, reserpine induced hypolocomotion, tacrine induced vacuous chewing movements, orofacial brusts and tongue protrusion. Antioxidant activity was assessed by using DPPH radical scavenging assay and H O scavenging assay. The results were analyzed by repeated 2 2 measure ANOVA followed by Dunnett's test. Results: Mixture 30 and 100 mg/kg shows extremely significant improvement in haloperidol induced catalepsy, reserpine induced hypolocomotion and tacrine induced vacuous chewing movements, orofacial burst and tongue protrusion as compare with HENJ and HEMP shows significant improvements in dose dependent manner. In DPPH and H O scavenging assay, both the extracts exhibited free radical 2 2

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Section: Nardostachys Jatamansimentioning

confidence: 99%

Comparative evaluation of Nardostachys jatamansi and Mucuna pruriens as neuroprotective in Parkinson's disease

Giri¹,

Bhalke²,

Prakash³

et al. 2020

Asian J Pharm Pharmacol

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“…Seeds of Mucuna are commonly used part of the plant, which are a rich source of nutritional and anti-nutritional compounds like l-dopa (anti-Parkinson's activity), antioxidants, phenolic, flavonoids, tannin, carbohydrates, starch, protein, micronutrients Sopanines and many more [9,12,26]. Antioxidant activities in this plant are mainly due to phenolic and various bioactive compounds present in the seed material [36,37].…”

Section: Bioactive Compounds From Various Parts Of Mucuna Species 21mentioning

confidence: 99%

“…Their application in cost-effective industrially important product formation is helpful for humankind, which upshots effective drug formulations and upsurges the nutritional level of food [47,48]. l-Dopa is a major component in different parts of Mucuna species [9]. This also helps in storing germplasm of endangered species, which in turn leads to regenerate new plantlets at any time.…”

Section: Bioactive Compounds From Callus Of Mucunamentioning

confidence: 99%

“…Ancient reports of Ayurveda suggest that Mucuna seed powder contributes in reducing the risks of certain cardiovascular diseases and neurodegenerative disease and also as a remedy for snake bite. The seeds of Mucuna have gained increasing attention among food scientists, nutrition specialists and pharmaceutical expertise due to their rich source of antioxidant, phenolic, flavonoids, l-dopa, proteins, starch, micronutrients, dietary fiber and bioactive compounds that play a pronounced role in the traditional as well as modern medicine all over the world [9,10]. The existing scenario shows ten reported Mucuna species that were studied recently by Pulikkalpura et al, from the Indian subcontinent [11], whereas Patil et al, also collected fourteen different species of Mucuna from various localities and further studied for their l-dopa content (anti-Parkinson's activity) [6,12].…”

Section: Introductionmentioning

confidence: 99%

“…Thus, it was consumed universally for the treatment of Parkinson's disease. Traditionally, in Ayurvedic science, Mucuna (velvet bean) plant is widely used to treat numerous diseases including parkinsonism [17][18][19][20][21] due to its l-dopa content as one of the principal constituents [9]. All parts of Mucuna have a great medicinal value in the ancient traditional medicinal system, and hence, it has a prodigious demand in the international and the Indian market [7,22].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bioactive Components of Magical Velvet Beans

Suryawanshi¹,

Kamble²,

Bapat³

et al. 2020

Legume Crops [Working Title]

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The plant Mucuna is an annual climbing shrub with long vines that can reach over fifteen meters in length. About 100-150 Mucuna species are found in the tropic and subtropic regions of both hemispheres of the earth. The genus Mucuna belongs to the family Leguminosae. It is commonly known as Kewanch, velvet bean, cowhage and kappikachhu and is found widely in India as a hardy, herbaceous, vigorous, twining annual plant. The size and dimension of the Mucuna seeds, pods, platelets and leaves change from species to species. The hair present on pods is anthelmintic, which causes itching. People are seeking great attention towards Mucuna due to its several medicinal properties, including L-DOPA (L-3, 4-dihydroxyphenylalanine) along with supplementary antioxidants that are used for treating Parkinson's disease and many neurodegenerative diseases. Thus it is being used in about 200 medicinal formulations. The current chapter outlines the work that determines the influence of different nutritional, anti-nutritional and medicinal values and bioactive agents from different parts of the Mucuna species present in India and its importance in medicine.

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