Comparative evaluation of Nardostachys jatamansi and Mucuna pruriens as neuroprotective in Parkinson's disease

Abstract

Objective: In the present study, comparative antioxidant and antiparkinsonian effect of hydroalcoholic extract of Nardostachys jatamansiMucuna pruriens (HENJ) and (HEMP) was studied. The Materials and methods: antiparkinsonian activity was evaluated by using haloperidol induced catalepsy, reserpine induced hypolocomotion, tacrine induced vacuous chewing movements, orofacial brusts and tongue protrusion. Antioxidant activity was assessed by using DPPH radical scavenging assay and H O scavenging assay. The results were analyzed by repeated 2 2 measure ANOVA followed by Dunnett's test. Results: Mixture 30 and 100 mg/kg shows extremely significant improvement in haloperidol induced catalepsy, reserpine induced hypolocomotion and tacrine induced vacuous chewing movements, orofacial burst and tongue protrusion as compare with HENJ and HEMP shows significant improvements in dose dependent manner. In DPPH and H O scavenging assay, both the extracts exhibited free radical 2 2

Antiparkinsonian Activity of Hydroalcoholic Extract of Operculina turpethum Roots in Reserpine Induced Parkinsonism in Wistar Rats

“…As compared with the control group 1:1 mixture (30, 100 mg/kg) showed extremely significant changes. The effect was observed due to the presence of levodopa, jatamansone and coumarinis as active chemical constituents present in the extracts along with supportive constituent and their antioxidant properties (21) .…”

“…In the absence of disease modifiers, herbal medication is perfectly the alternative source that has been gradually useful in the various disease including PD due to multifunctionality of phytoconstituents and their remarkable efficacy with lesser adverse effects. Numerous herbal medications have been used in the past to treat neurodegenerative diseases and their phytochemicals might be helpful in disease modifying or to slow down the progression of PD (21) .…”