Exploring the potentials of nurture: 2nd and 3rd generation explant human skin equivalents

Danso, Mogbekeloluwa O.; Drongelen, Vincent van; Mulder, Aat A.; Gooris, Gert S.; Smeden, Jeroen van; Ghalbzouri, Abdoelwaheb El; Bouwstra, Joke A.

doi:10.1016/j.jdermsci.2014.12.002

Cited by 6 publications

(3 citation statements)

References 34 publications

(28 reference statements)

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“…Drug absorption via the skin seems to be restricted by the stratum corneum. The kinetics of skin permeation can be analyzed using in-vitro investigations utilizing a freshly excised skin sample affixed to a precisely calibrated skin permeation cell [35].…”

Section: 𝑃 = 𝐾 𝐷 ℎmentioning

confidence: 99%

Design Features, Quality by Design Approach, Characterization, Therapeutic Applications and Clinical Considerations of Transdermal Therapeutic Systems – A Comprehensive Review

Sivadasan

2024

Preprint

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Transdermal drug delivery systems (TDDS) are designed to administer a consistent and effective dose of medication through the patient's skin. These pharmaceutical preparations are self-contained, discrete dosage forms designed to be placed topically on intact skin to release the active component at a controlled rate by penetrating the skin barriers. This medication provides a continuous and prolonged administration of a substance at a consistent rate. TDDS, or transdermal drug delivery system, has gained significant attention as a non-invasive method of administering drugs to vulnerable patient populations, such as pediatric and geriatric patients. This approach is considered easy to administer and helps overcome bioavailability issues associated with conventional drug delivery, which can be hindered by poor absorption and metabolism. TDDS has various advantages compared to conventional methods of drug administration. It is less intrusive, more patient-friendly, and can circumvent first-pass metabolism and the corrosive acidic environment of the stomach that happens when medications are taken orally. Multiple methodologies have been devised to augment the transdermal permeability of diverse pharmaceutical substances. Recent advancements in transdermal drug delivery systems have facilitated the precise delivery of medications to the intended site of action by improving the penetration of drugs through the outermost layer of the skin, known as the stratum corneum, resulting in enhanced drug availability throughout the body. This review seeks to provide a concise overview of the several methods employed in the production of TDDS, as well as their evaluation, therapeutic uses, clinical considerations, and current advancements. These advancements have resulted in the development of intelligent, biodegradable, and highly efficient transdermal drug delivery systems.

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Section: 𝑃 = 𝐾 𝐷 ℎmentioning

confidence: 99%

Design Features, Quality by Design Approach, Characterization, Therapeutic Applications and Clinical Considerations of Transdermal Therapeutic Systems – A Comprehensive Review

Sivadasan

2024

Preprint

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“…It consists of two phases: the short periodicity phase (SPP) and the long periodicity phase (LPP), which have repeat distances of roughly 6 nanometers and 13 nanometers, respectively [3]. [4] Within the lipid lamellae, lipids are predominantly structured in a dense orthorhombic packing, with a small proportion of lipids arranged in a hexagonal packing. The viable epidermis (VE), which lies underneath the stratum corneum, is a cellular, avascular tissue that measures 50-100 microns in thickness [5].…”

Section: Introductionmentioning

confidence: 99%

Microneedles (MNs) - A versatile transdermal drug delivery system: Types, Fabrication Methodology, Release Mechanism, Evaluation Parameters, Biological Application and Clinical Case Studies

Patel¹,

Parikh²,

Patel³

et al. 2021

TJOPAM

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Because of the limitations of the oral drug delivery system, as well as the discomfort associated with the usage of needles in the case of injections, drug delivery research has shifted significantly toward the transdermal route of administration. Topical creams, gels, and transdermal patches are the most often utilised means of transdermal administration of drugs. Since the stratum corneum layer of the skin acts as a barrier to a drug molecule, the effect of the majority of therapeutic agents is limited. As a result, only a small number of molecules are able to reach the site of action. A new type of delivery method, known as microneedles, is being developed to improve the distribution of drugs through this route while also overcoming the various issues associated with existing formulations. Non-invasive and painless feature of microneedles have making them ideal for self-administration. This review describes various type of microneedles and their design, fabrication methodology, various materials used in fabrication of microneedles, drug release mechanism from the microneedles, evaluation parameters, it’s biological application, update about recent clinical studies and in last, challenges and future perspective of microneedles as drug delivery system.

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“…These include the short periodicity phase (SPP) and the long periodicity phase (LPP) with repeat distances of approximately 6 and 13 nm, respectively [ 3 ]. Within the lipid lamellae, the lipids are mainly organized in a dense orthorhombic packing, although a fraction of lipids adopt a hexagonal packing [ 4 ]. Below the stratum corneum is the viable epidermis (VE), which is a cellular, avascular tissue measuring 50–100 μm thick [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Transdermal Delivery of Drugs with Microneedles—Potential and Challenges

2015

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Transdermal drug delivery offers a number of advantages including improved patient compliance, sustained release, avoidance of gastric irritation, as well as elimination of pre-systemic first-pass effect. However, only few medications can be delivered through the transdermal route in therapeutic amounts. Microneedles can be used to enhance transdermal drug delivery. In this review, different types of microneedles are described and their methods of fabrication highlighted. Microneedles can be fabricated in different forms: hollow, solid, and dissolving. There are also hydrogel-forming microneedles. A special attention is paid to hydrogel-forming microneedles. These are innovative microneedles which do not contain drugs but imbibe interstitial fluid to form continuous conduits between dermal microcirculation and an attached patch-type reservoir. Several microneedles approved by regulatory authorities for clinical use are also examined. The last part of this review discusses concerns and challenges regarding microneedle use.

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Exploring the potentials of nurture: 2nd and 3rd generation explant human skin equivalents

Cited by 6 publications

References 34 publications

Design Features, Quality by Design Approach, Characterization, Therapeutic Applications and Clinical Considerations of Transdermal Therapeutic Systems – A Comprehensive Review

Design Features, Quality by Design Approach, Characterization, Therapeutic Applications and Clinical Considerations of Transdermal Therapeutic Systems – A Comprehensive Review

Microneedles (MNs) - A versatile transdermal drug delivery system: Types, Fabrication Methodology, Release Mechanism, Evaluation Parameters, Biological Application and Clinical Case Studies

Transdermal Delivery of Drugs with Microneedles—Potential and Challenges

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