Transdermal Delivery of Drugs with Microneedles—Potential  and Challenges

Ita, Kevin

doi:10.3390/pharmaceutics7030090

Cited by 371 publications

(231 citation statements)

References 53 publications

(117 reference statements)

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“…First, skin pore closure needs to be additionally investigated after micro-needle patches application as it relates to the risk of infections. Second, it is difficult to control the drug amount in micro-needle patches26. To overcome these challenges, a new drug delivery technique with higher efficacy and safety is required.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Micro-Spicule Containing Epidermal Growth Factor on Periocular Wrinkles

Lim

Han³

et al. 2017

Ann Dermatol

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BackgroundMicro-needle patches have been recently used to increase skin permeability, which improves drug delivery, and for cosmetic purposes. However, these patches may often have limited efficacy due to insufficient skin penetration and reduced compliance caused by discomfort.ObjectiveWe evaluated the efficacy and the safety of soluble micro-spicule containing epidermal growth factor (MS-EGF) for the treatment of periocular wrinkles.MethodsTwenty healthy volunteers aged 33 to 54 years were enrolled in a randomized, controlled, split-face study. For 4 weeks, a periocular wrinkle was treated daily with either a soluble MS-EGF cream or a cream containing EGF alone. All subjects underwent 8 weeks of follow-up. Efficacy was assessed using an ultrasonic measurement of dermal depth and density, digital skin image analysis, 5-point photonumeric scale for periocular wrinkles and subjective satisfaction.ResultsMS-EGF group showed statistically significant increase of dermal depth and density compared to EGF alone group after 4 and 8 weeks. In addition, there was a marked improvement shown in clinical and 3-dimensional skin image in MS-EGF group. The treatments were well-tolerated; no significant side-effect was noted.ConclusionThe MS-EGF formulation may represent an effective and biocompatible advance in the treatment of periocular wrinkles.

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Section: Discussionmentioning

confidence: 99%

The Effect of Micro-Spicule Containing Epidermal Growth Factor on Periocular Wrinkles

Lim

Han³

et al. 2017

Ann Dermatol

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“…Currently, there are approximately 23 active and 39 completed National Institutes of Health (NIH) clinical trials related to MNs for treating a variety of diseases, including type 1 diabetes, psoriatic plaques and topical anesthesia [184]. Most studies utilize commercial available hollow MN infusion systems, and a few cases have investigated the effectiveness of using polymeric MN for protein drug delivery.…”

Section: Discussionmentioning

confidence: 99%

Polymeric microneedles for transdermal protein delivery

Ye¹,

Yu²,

Wen³

et al. 2018

Advanced Drug Delivery Reviews

268

169

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The intrinsic properties of therapeutic proteins generally present a major impediment for transdermal delivery, including their relatively large molecule size and susceptibility to degradation. One solution is to utilize microneedles (MNs), which are capable of painlessly traversing the stratum corneum and directly translocating protein drugs into the systematic circulation. MNs can be designed to incorporate appropriate structural materials as well as therapeutics or formulations with tailored physicochemical properties. This platform technique has been applied to deliver drugs both locally and systemically in applications ranging from vaccination to diabetes and cancer therapy. This review surveys the current design and use of polymeric MNs for transdermal protein delivery. The clinical potential and future translation of MNs are also discussed.

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“…for delivery. Many advances have been made in this area [ 28 ]. Scientists are now studying the possibility of dissolving microneedles.…”

Section: Enhancement Using Physical Methodsmentioning

confidence: 99%