Exploring the Pharmacological Mechanism of Quercetin-Resveratrol Combination for Polycystic Ovary Syndrome: A Systematic Pharmacological Strategy-Based Research

Abstract

Resveratrol and quercetin have effects on polycystic ovary syndrome (PCOS). Hence, resveratrol combined with quercetin may have better effects on it. However, because of the limitations in animal and human experiments, the pharmacological and molecular mechanism of quercetin-resveratrol combination (QRC) remains to be clarified. In this research, a systematic pharmacological approach comprising multiple compound target collection, multiple potential target prediction, and network analysis was used for comparing the characteristic of resveratrol, quercetin and QRC, and exploring the mechanism of QRC. After that, four networks were constructed and analyzed: (1) compound-compound target network; (2) compound-potential target network; (3) QRC-PCOS PPI network; (4) QRC-PCOS-other human proteins (protein-protein interaction) PPI network. Through GO and pathway enrichment analysis, it can be found that three compounds focus on different biological processes and pathways; and it seems that QRC combines the characteristics of resveratrol and quercetin. The in-depth study of QRC further showed more PCOS-related biological processes and pathways. Hence, this research not only offers clues to the researcher who is interested in comparing the differences among resveratrol, quercetin and QRC, but also provides hints for the researcher who wants to explore QRC’s various synergies and its pharmacological and molecular mechanism.

The Effect of Hedysarum multijugum Maxim.-Chuanxiong rhizoma Compound on Ischemic Stroke: A Research Based on Network and Experimental Pharmacology

“…, Chuanxiong rhizoma , Pheretima , and Bombyx batryticatus . Oral bioavailability (OB), drug-likeness (DL), and Caco-2 permeability were utilized to identify the potential bioactive compounds of HCC [ 17 , 18 , 23 – 26 ]. The compounds that meet the standards of OB ≥ 30%, Caco‐2 > −0.4, and DL ≥ 0.18 were regarded as oral absorbable compounds with biologically active [ 17 , 18 , 23 – 26 ].…”

“…The result is saved in TSV format. The node 1, node 2, and combined score information in the file is retained and imported into Cytoscape software to draw the interaction network [ 17 , 18 , 34 ].…”

“…These different clusters represent different biological modules, and it is possible to treat diseases by intervening in these modules. The plugin of Cytoscape, MCODE, was utilized to detect clusters in PPI network [ 17 , 18 ].…”

“…The integration strategy of network biology and multidirectional pharmacology is conducive to expanding the available drug target space and is expected to become one of the new strategies for drug discovery, especially in the field of research and development of Chinese medicine formulae [ 14 – 18 ]. Our previous research successfully analyzed the molecular mechanisms and pharmacodynamic components of traditional Chinese medicine in the fields of cardiovascular and cerebrovascular diseases, tumors, and complex endocrine diseases through the chemical informatics and complex pharmacology methodological strategies [ 17 , 18 ]. Therefore, in this research, we hope to explore the biological mechanism of endoplasmic reticulum stress after HCC intervention in IS by systematic pharmacology.…”

Integrating systematic biological and proteomics strategies to explore the pharmacological mechanism of danshen yin modified on atherosclerosis

“…29 The compounds with OB ≥ 30%, Caco-2> −0.4 and DL ≥ 0.18 were considered to be orally absorbable and pharmacologically active (namely, potential compounds). [19][20][21][22][23][24][25][26][27]29 Due to the limitation of predicting potential components based on pharmacokinetic parameters only, 30 in order to avoid omission of components, we searched a large number of literatures to supplement orally absorbable compounds with bioactive. Finally, after searching, a total of 34 components were added from the reference.…”