Antioxidant supplementations ameliorate PCOS complications: a review of RCTs and insights into the underlying mechanisms

Efficacy of antioxidant supplementation in improving endocrine, hormonal, inflammatory, and metabolic statuses of PCOS: a meta-analysis and systematic review

“…The inclusion criteria were as follows: (1) studies published in English and peer-reviewed, randomized, and cluster randomized controlled trials (RCTs); (2) PCOS diagnosed according to the Rotterdam criteria; (3) intervention: the treatment group receiving antioxidants and the control group receiving placebo; (4) the primary outcome being a metabolic index and the secondary outcome being a basic index; and (5) the study using biological and chemical organic nutrients as antioxidants, including vitamin D, minerals, polyunsaturated fatty acids, and synbiotic beverages, including vitamin D, vitamin E, carnitine, coenzyme Q10, acetylcysteine, omega-3, folate, selenium, zinc, resveratrol, curcumin, garlic, concentrated pomegranate juice, and complex nutrients. 14…”

“…They have been reported to have a wide range of functions, including improving liver damage induced by alcohol, drugs, and radiation, 10 atherosclerosis, 11 anti-inflammation associated with obesity, and PCOS. 12–14 Related studies have found that pomegranate juice is rich in nutrients, including vitamins and minerals, 15 which can increase serum antioxidant enzyme levels and have an antioxidant effect on polycystic ovaries. 16,17 Curcumin, Melissa officinalis , and resveratrol have also been shown to reduce the levels of HA and IR, as well as inflammation, 18 thus exerting beneficial effects on patients with PCOS.…”

Apoptosis, inflammation, and oxidative stress in infertility: A mini review

“…Oxidative stress is thought to destroy the peritoneal cavity by making it easier for ectopic endometrium cells to stick together [66] . As we've already talked about, endometriosis is an inflammatory disease that causes endometrial tissue to grow on the outside of the uterus.…”

Oxidative stress and antioxidant imbalance in ovulation disorder in patients with polycystic ovary syndrome

“…Based on a large number of studies confirming that PCOS patients do exhibit varying degrees of OS, antioxidant therapy may become an important direction for the treatment of PCOS ( 74 ) ( Table 1 ). At present, there have been clinical studies on the use of antioxidants in patients with PCOS.…”