Exploring the molecular basis for the metal-mediated assembly of alginate gels

Stewart, Matthew B.; Gray, Stephen; Vasiljevic, Todor; Orbell, John D.

doi:10.1016/j.carbpol.2013.11.034

Cited by 45 publications

(49 citation statements)

References 20 publications

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“…This result reflects our current understanding that the minimum length of a stable junction zone is 8 guluronic acids, capable of complexing 4 Ca 2+ ions (Stokke et al, 1993) and so we identify the strong interaction observed for the 4-site oligoG as the eggbox junction zone. Candidates for the identity of the weaker interaction may be the 'tilted eggbox', formed at low ratios of Ca 2+ to G in alginates (Borgogna, Skjåk-Braek, Paoletti, & Donati, 2013) or the perpendicular junction involving 3 Ca 2+ ions identified by Stewart et al (Stewart, Gray, Vasiljevic, & Orbell, 2014) from molecular dynamics simulations. The hypothesis that junction zones longer than 8 monomers take longer than 20 ms to form was tested for the 2-, 4-and 10-site oligoGs by increasing the dwell time of the AFM probe at the surface to from 0 to 50, 200 and 500 ms (giving total times that the probe and sample are within 20nm of each other of 20, 70, 220 and 520 ms).…”

Section: Distinguishing Single and Multiple Bond Rupture Eventsmentioning

confidence: 99%

Single molecule investigation of the onset and minimum size of the calcium-mediated junction zone in alginate

Bowman

Aarstad

Nakamura

et al. 2016

Carbohydrate Polymers

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Section: Distinguishing Single and Multiple Bond Rupture Eventsmentioning

confidence: 99%

Single molecule investigation of the onset and minimum size of the calcium-mediated junction zone in alginate

Bowman

Aarstad

Nakamura

et al. 2016

Carbohydrate Polymers

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“…The use of sodium alginate (SA), a natural polymer extracted from brown seaweed, has found numerous applications . The reasons for this success are its biocompatibility, renewability, low cost, and the ability to create gel in the presence of bivalent ions . This property is directly correlated to its composition.…”

Section: Introductionmentioning

confidence: 99%

Alginate and alginate/hyaluronic acid membranes generated by electrospinning in wet conditions: Relationship between solution viscosity and spinnability

Vicini¹,

Mauri²,

Vita³

et al. 2018

J of Applied Polymer Sci

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The methodology to create alginate and alginate/hyaluronic acid membranes, which involves wet conditions electrospinning, is presented in this paper. The wet conditions allow simultaneously to work in water solutions avoiding the toxic solvents and to obtain crosslinked alginate. An accurate rheological characterization of all solutions examined is performed. By optimizing the electrospinning parameters, it is possible to obtain alginate membranes with homogeneous nanofibers and a narrow diameter distribution (i.e., around 100 nm) as well as alginate/hyaluronic acid membranes characterized by a network of bimodal distribution of the dimensions, namely nanofibers with a diameter comparable to the ones of the alginate membrane, in which are blocked microfibers with a ribbon like appearance, as observed in the SEM images. In order to facilitate the electrospinning process, poly(ethylene oxide) is added to the solutions and then removed after membranes preparation, as demonstrated by the differential scanning calorimetry results, obtaining membranes made up only biopolymers. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46390.

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“…This polymer has shown interesting characteristics in many fields and applications, from pharmaceutical to environmental protection [2,3]. This wide range of applications is due to its ability to form a physical hydrogel, when bivalent cations (Me 21 ) are added to the alginate solution [4]. The polymer chain is made of (1,4)-linked b-D-mannuronic acid (M), and its C-5 epimere, a-Lguluronic acid (G), able to connect to each other in long sequences of M-Blocks, G-Blocks, and MG-Blocks [5,6].…”

Section: Introductionmentioning

confidence: 99%

Alginate gelling process: Use of bivalent ions rich microspheres

Vicini

Mauri

Wichert

et al. 2017

Polymer Engineering & Sci

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A new approach for obtaining a controlled gelling process of sodium alginate, based on the use of bivalent ions rich alginate microbeads added as crosslinkers, is presented. Normally, calcium ions are used in the gelation of alginate solutions. In this article, alginate microspheres, obtained by electrospray, and enriched with different bivalent ions (Ca2+, Ba2+, and Mg2+) are described. Because of the solvent/non‐solvent system, it is possible to use also Mg2+ as a crosslinker for alginate, despite the fact that it had long been regarded as a nongelling bivalent ion. The morphology and the ions content of the microspheres are evaluated. Gels are characterized according to type and amount of the ions added to the alginate solution, using rheological measurements to assess the variation in the storage modulus (G′) and loss modulus (G″). The gel point is then detected using magnesium ions. The new approach guarantees a working system that could be easily applied in different fields. POLYM. ENG. SCI., 57:531–536, 2017. © 2017 Society of Plastics Engineers

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Exploring the molecular basis for the metal-mediated assembly of alginate gels

Abstract: 17The binding of sodium and calcium ions to single and multiple poly-G decamer strands has

Cited by 45 publications

References 20 publications

Single molecule investigation of the onset and minimum size of the calcium-mediated junction zone in alginate

Single molecule investigation of the onset and minimum size of the calcium-mediated junction zone in alginate

Alginate and alginate/hyaluronic acid membranes generated by electrospinning in wet conditions: Relationship between solution viscosity and spinnability

Alginate gelling process: Use of bivalent ions rich microspheres

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