Exploring the mechanisms of alcohol-related damage in oral mucosa – is oxidative stress associated with the increase in cell proliferation in rat tongue epithelium?

Carrard, Vinícius Coelho; Pires, André Simões; Mendez, Marina; Pasquali, Matheus A.B.; Badauy, Cristiano Macabú; Lauxen, Isabel S.; Moreira, José Cláudio Fonseca; Filho, Manoel Sant’Ana

doi:10.3109/13880209.2012.715171

Cited by 5 publications

(6 citation statements)

References 64 publications

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“…The results of Carrard et al (2013) are contradictory to the above conclusions. These researchers demonstrated that increased cell proliferation with alcohol-related mucosa damage is not directly caused by the oxidative-reductive imbalance in tongue tissue.…”

Section: Ethanol-derived Reactive Oxygen Species and Saliva And Salivary Glandsmentioning

confidence: 59%

“…CAT is an enzyme without an antioxidant response element in its promoter center and it is not subjected to NrF2-mediated transcriptional activation. It is interesting to note that the authors observed a decrease in the concentration of lipid peroxidation products after 14 and 60 days of exposure to ethanol, which, according to them, is evidence of positive modification of cell membranes (Carrard et al, 2009(Carrard et al, , 2013. The keratinized layer of the tongue epithelium is a tissue consisting of extremely flattened and dehydrated cells.…”

Section: Ethanol-derived Reactive Oxygen Species and Saliva And Salivary Glandsmentioning

confidence: 95%

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Ethanol- and Cigarette Smoke-Related Alternations in Oral Redox Homeostasis

2022

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Alcohol abuse as well as smoking cigarettes has been proven to negatively affect the oral environment. The aim of this work was to provide a systematic review of the literature on the influence of ethanol and cigarette smoking on oral redox homeostasis. A search was performed for scientific articles indexed in the PubMed, Medline and Web of Science databases. We identified 32,300 articles, of which 54 were used for the final review, including the results from 2000 to 2021. Among the publications used to write this article, n = 14 were related to the influence of alcohol consumption (clinical studies n = 6, experimental studies n = 8) and n = 40 were related to the influence of smoking (clinical studies n = 33, experimental studies n = 7) on oral redox homeostasis. The reviewed literature indicates that alcohol abusers and smokers are more likely to suffer from salivary gland dysfunction, as well as develop precancerous lesions due to DNA damage. Compared to alcohol abstainers and non-smokers, alcohol drinkers and smokers are also characterized by a deterioration in periodontal health measured by various indicators of periodontal status. In summary, alcohol abuse and smoking are associated with disrupted oral redox homeostasis, which may lead not only to tooth loss, but also contribute to various adverse effects related to mental health, digestive processes and chronic inflammation throughout the human body.

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Section: Ethanol-derived Reactive Oxygen Species and Saliva And Salivary Glandsmentioning

confidence: 59%

Section: Ethanol-derived Reactive Oxygen Species and Saliva And Salivary Glandsmentioning

confidence: 95%

Ethanol- and Cigarette Smoke-Related Alternations in Oral Redox Homeostasis

2022

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“…Moreover, increase in cell proliferation rate has been demonstrated in tongue epithelium of rodents subjected to chronic alcohol consumption. 24,25 Our main finding was an increased frequency of MN in cells exfoliated from the border of the tongue of crack cocaine users when compared with alcoholics and controls. This result reinforces the findings by Lima et al 11 and Almeida et al 23 The former had demonstrated the same alteration, however, with nonsignificant differences in relation to controls.…”

Section: Discussionmentioning

confidence: 91%

“…Moreover, increase in cell proliferation rate has been demonstrated in tongue epithelium of rodents subjected to chronic alcohol consumption. 24,25…”

Section: Discussionmentioning

confidence: 99%

Nuclear changes in oral mucosa of alcoholics and crack cocaine users

et al. 2015

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The effects of drugs of abuse on oral mucosa are only partly understood. The aims of the present study were to: (1) evaluate the frequency of nuclear changes in normal-appearing oral mucosa of alcoholics and crack cocaine users and (2) assess their association with cell proliferation rate. Oral smears were obtained from the border of the tongue and floor of the mouth of 26 crack cocaine users (24 males and 2 females), 29 alcoholics (17 males and 12 females), and 35 controls (17 males and 18 females). Histological slides were submitted to Feulgen staining to assess the frequency of micronuclei (MN), binucleated cells (BN), broken eggs (BE), and karyorrhexis (KR). A significant increase in the frequency of MN was observed in cells exfoliated from the tongue of crack cocaine users ( p = 0.01), and alcoholics showed a higher frequency of KR in cells obtained from the floor of the mouth ( p = 0.01). Our findings suggest that the use of crack cocaine induces clastogenic effects, whereas alcoholism is associated with higher degrees of keratinization in the floor of the mouth.

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“…It has been reported that alcohol acts as an independent risk factor for oral cancer [11][12][13]. Some studies have shown the relationship between the dose and/or duration of alcohol intake [12,14,15], but the mechanism of action remains unknown [11,16,17].…”

Section: Oral Cavitymentioning

confidence: 99%

Damage to Oral Mucosae Induced by Weekend Alcohol Consumption: The Role of Gender and Alcohol Concentration

et al. 2022

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The damage caused by chronic alcohol consumption is frequently reported, but the effects caused by weekend recreational consumption, which is much more frequent than even daily consumption, have not, to our knowledge, been reported. The metabolism of ethanol, once consumed, starts from the mouth, and the biotransformation process follows different routes. In this study, the effect of weekend alcohol consumption on the oral cavity was observed. Methods: Thirty male and female rats were divided into six groups (n = 5), with control groups (male/female) and groups administered with 5% and 40% ethanol solution ad libitum consumption 2 days a week for 3 months. After treatment, the animals were sacrificed, an incisional slice of the cheek and back of the tongue was obtained, and the tissues were processed according to the histological technique and routine staining (hematoxylin-eosin, H&E). Samples were observed using light microscopy. Results: Histological changes were observed in samples of tongue and cheek mucosa including different levels of keratinization of the surface layer. Epithelial dysplasia, acanthosis, and chronic inflammation were also observed. The vascularization level also increased because of the ethanol-induced damage. The results were very similar between female and male groups. Conclusion: Weekend alcohol consumption for a period of 3 months causes oral-cavity tissue alterations that could contribute to tumor growth and the development of cancer in the oral cavity.

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Exploring the mechanisms of alcohol-related damage in oral mucosa – is oxidative stress associated with the increase in cell proliferation in rat tongue epithelium?

Cited by 5 publications

References 64 publications

Ethanol- and Cigarette Smoke-Related Alternations in Oral Redox Homeostasis

Ethanol- and Cigarette Smoke-Related Alternations in Oral Redox Homeostasis

Nuclear changes in oral mucosa of alcoholics and crack cocaine users

Damage to Oral Mucosae Induced by Weekend Alcohol Consumption: The Role of Gender and Alcohol Concentration

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