Exploring the interaction between childhood maltreatment and temperamental traits on the severity of borderline personality disorder

Martín-Blanco, Ana; Soler, Joaquim; Villalta, Laia; Feliu‐Soler, Albert; Elices, Matilde; Pérez, Ví­ctor; Arranz, Maria; Ferraz, Liliana; Álvarez, Enrique; Pascual, Juan Carlos

doi:10.1016/j.comppsych.2013.08.026

Cited by 56 publications

(45 citation statements)

References 46 publications

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“…Neuroticism is a common predictor of many psychological disorders, including alcohol misuse, Alzheimer's disease, depression, schizophrenia, and substance abuse disorder . Our finding that the relationship between childhood abuse and migraine is mediated by neurotic personality traits is consistent with other studies that have found similar mediating effect of neuroticism on the relationship between childhood abuse and other health problems . It has been proposed that the long‐term negative health implications of childhood maltreatment may be a result of the proximal impact of maltreatment on personality development during the formative years .…”

Section: Discussionsupporting

confidence: 90%

“…There is empirical evidence that childhood maltreatment increases the risk for developing maladaptive personality traits . Furthermore, personality traits, especially neuroticism, have been shown to mediate the relationship between childhood maltreatment and several mental health variables (eg, depression, psychological distress, anxiety, substance abuse, and alcohol dependence) . Our primary hypothesis is that the effect of childhood abuse on migraine is mediated through neuroticism.…”

Section: Introductionmentioning

confidence: 99%

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Do Personality Traits Mediate the Relationship Between Childhood Abuse and Migraine? An Exploration of the Relationships in Young Adults Using the Add Health Dataset

et al. 2017

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Do Personality Traits Mediate the Relationship Between Childhood Abuse and Migraine? An Exploration of the Relationships in Young Adults Using the Add Health Dataset

et al. 2017

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“…Prospective studies with large cohorts of abused/neglected children support this assumption [4][5][6]. Furthermore, an association between childhood traumas and BPD severity in adulthood has been observed [7].…”

Section: Introductionmentioning

confidence: 91%

The role of hypothalamus–pituitary–adrenal genes and childhood trauma in borderline personality disorder

Martín-Blanco

Ferrer

Soler

et al. 2015

Eur Arch Psychiatry Clin Neurosci

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Current knowledge suggests that borderline personality disorder (BPD) results from the interaction between genetic and environmental factors. Research has mainly focused on monoaminergic genetic variants and their modulation by traumatic events, especially those occurring during childhood. However, to the best of our knowledge, there are no studies on the genetics of hypothalamus-pituitary-adrenal (HPA) axis, despite its vulnerability to early stress and its involvement in BPD pathogenesis. The aim of this study was to investigate the contribution of genetic variants in the HPA axis and to explore the modulating effect of childhood trauma in a large sample of BPD patients and controls. DNA was obtained from a sample of 481 subjects with BPD and 442 controls. Case-control differences in allelic frequencies of 47 polymorphisms in 10 HPA axis genes were analysed. Modulation of genetic associations by the presence of childhood trauma was also investigated by dividing the sample into three groups: BPD with trauma, BPD without trauma and controls. Two FKBP5 polymorphisms (rs4713902-C and rs9470079-A) showed significant associations with BPD. There were also associations between BPD and haplotype combinations of the genes FKBP5 and CRHR1. Two FKBP5 alleles (rs3798347-T and rs10947563-A) were more frequent in BPD subjects with history of physical abuse and emotional neglect and two CRHR2 variants (rs4722999-C and rs12701020-C) in BPD subjects with sexual and physical abuse. Our findings suggest a contribution of HPA axis genetic variants to BPD pathogenesis and reinforce the hypothesis of the modulating effect of childhood trauma in the development of this disorder.

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“…In a recent study, Martin-Blanco and collaborators [10] have hypothesized that the interaction of childhood trauma and temperamental traits could be associated with the severity of BPD. In this regard, they have evaluated the self-reported history of trauma, the psychobiological temperamental traits and the severity of the BPD symptoms in a cohort of 130 BPD patients.…”

Section: Introductionmentioning

confidence: 99%

Borderline personality disorder and childhood trauma: exploring the affected biological systems and mechanisms

et al. 2017

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BackgroundAccording to several studies, the onset of the Borderline Personality Disorder (BPD) depends on the combination between genetic and environmental factors (GxE), in particular between biological vulnerabilities and the exposure to traumatic experiences during childhood. We have searched for studies reporting possible alterations in several biological processes and brain morphological features in relation to childhood trauma experiences and to BPD. We have also looked for epigenetic mechanisms as they could be mediators of the effects of childhood trauma in BPD vulnerability.DiscussionWe prove the role of alterations in Hypothalamic-Pituitary-Adrenal (HPA) axis, in neurotrasmission, in the endogenous opioid system and in neuroplasticity in the childhood trauma-associated vulnerability to develop BPD; we also confirm the presence of morphological changes in several BPD brain areas and in particular in those involved in stress response.SummaryNot so many studies are available on epigenetic changes in BPD patients, although these mechanisms are widely investigated in relation to stress-related disorders. A better comprehension of the biological and epigenetic mechanisms, affected by childhood trauma and altered in BPD patients, could allow to identify “at high risk” subjects and to prevent or minimize the development of the disease later in life.

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Exploring the interaction between childhood maltreatment and temperamental traits on the severity of borderline personality disorder

Cited by 56 publications

References 46 publications

Do Personality Traits Mediate the Relationship Between Childhood Abuse and Migraine? An Exploration of the Relationships in Young Adults Using the Add Health Dataset

Do Personality Traits Mediate the Relationship Between Childhood Abuse and Migraine? An Exploration of the Relationships in Young Adults Using the Add Health Dataset

The role of hypothalamus–pituitary–adrenal genes and childhood trauma in borderline personality disorder

Borderline personality disorder and childhood trauma: exploring the affected biological systems and mechanisms

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