Do Personality Traits Mediate the Relationship Between Childhood Abuse and Migraine? An Exploration of the Relationships in Young Adults Using the Add Health Dataset

Karmakar, Monita; Elhai, Jon D.; Amialchuk, Aliaksandr; Tietjen, Gretchen E.

doi:10.1111/head.13206

Cited by 16 publications

(7 citation statements)

References 73 publications

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“…There is also evidence of neuroticism as a potential mediator for the relationship between childhood abuse and migraine. These results have been confirmed through direct and indirect statistical analyses [ 87 ]. The relationship between migraine/headaches and childhood abuse has been established in large non-clinic-based samples together with several small case control studies using clinic and non-clinic-based sampling frames [ 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 ].…”

Section: Resultsmentioning

confidence: 57%

“…In fact, it is well-known that personality traits (especially neuroticism) and childhood maltreatment have been independently associated with several negative health outcomes later in life, including migraine [ 87 ]. These results are in line with the previous evidence in which personality traits, especially neuroticism, are mediators for the relationship between childhood maltreatment and several mental health variables (i.e., depression, psychological distress, anxiety, substance abuse, alcohol dependence, etc.)…”

Section: Resultsmentioning

confidence: 99%

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Migraine and Neuroticism: A Scoping Review

Galvez-Sánchez

Montoro

2022

Behavioral Sciences

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Headache is the first cause of consultation in neurology, and one of the most frequent reasons for consultation in general medicine. Migraine is one of the most common, prevalent, and socio-economic and socioeconomically impactful disabling primary headache disorders. Neuroticism can be conceptualized as a disposition to suffer anxiety and emotional disorders in general. Neuroticism has been associated with various mental and physical disorders (e.g., chronic pain, depression). With the aim to explore in depth the relationship between migraine and neuroticism, and contribute to the understanding of this relation in order to provide a better treatment for migraine patients based on a personalized and more comprehensive approach, a scoping review was performed using PubMed, Scopus, and Web of Science. Databases were searched independently by the two researchers, reaching a final set of 18 articles to be included. The search terms were: migraine and neuroticism. Neuroticism seems to be highly prevalent in migraine patients. Findings reveal that migraine patients with comorbid depression and anxiety showed higher levels of neuroticism. Depression has been associated with an increased risk of transformation from episodic to chronic migraine whereas neuroticism might be a mediator factor. Neuroticism also might be a mediator factor between childhood maltreatment and migraine. The revision conducted confirms that: (1) Migraine patients used to have a higher level of neuroticism and vulnerability to negative affect, compared to non-migraineurs and tension-type headache patients. (2) Neuroticism is associated with migraine. Nonetheless, more research is needed to clarify potential moderators of this relationship and the role of neuroticism itself in this disease. This knowledge might be useful in order to promote a better management of negative emotions as part of intervention programs in migraine.

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Section: Resultsmentioning

confidence: 57%

Section: Resultsmentioning

confidence: 99%

Migraine and Neuroticism: A Scoping Review

Galvez-Sánchez

Montoro

2022

Behavioral Sciences

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“…There was an influence of early life family-level factors on the prospective risk of developing migraine moderated through symptoms of depression and anxiety. Moreover, adverse childhood experiences have been demonstrated to have a stable association with an adult diagnosis of migraine [ 13 – 15 ], and the association seems to be mediated through neuroticism [ 16 ]. Pain as a neonate, defined as prescribed analgesics during stays at the neonatal intensive care unit, has also shown an association with an earlier onset of migraine [ 17 ].…”

Section: Resultsmentioning

confidence: 99%

Is there a causal relationship between stress and migraine? Current evidence and implications for management

et al. 2021

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Background The purpose of this narrative review is to examine the literature investigating a causal relationship between stress and migraine and evaluate its implications for managing migraine. Methods PubMed, PsycINFO and CINAHL were searched from 1988 to August 2021, identifying 2223 records evaluating the relationship between stress and migraine. Records were systematically screened. All potentially relevant records were thematically categorized into six mechanistic groups. Within each group the most recent reports providing new insights were cited. Results First, studies have demonstrated an association of uncertain causality between high stress loads from stressful life events, daily hassles or other sources, and the incidence of new-onset migraine. Second, major stressful life events seem to precede the transformation from episodic to chronic migraine. Third, there is some evidence for changes in levels of stress as a risk factor for migraine attacks. Research also suggests there may be a reversed causality or that stress-trigger patterns are too individually heterogeneous for any generalized causality. Fourth, migraine symptom burden seems to increase in a setting of stress, partially driven by psychiatric comorbidity. Fifth, stress may induce sensitization and altered cortical excitability, partially explaining attack triggering, development of chronic migraine, and increased symptom burden including interictal symptom burden such as allodynia, photophobia or anxiety. Finally, behavioral interventions and forecasting models including stress variables seem to be useful in managing migraine. Conclusion The exact causal relationships in which stress causes incidence, chronification, migraine attacks, or increased burden of migraine remains unclear. Several individuals benefit from stress-oriented therapies, and such therapies should be offered as an adjuvant to conventional treatment and to those with a preference. Further understanding the relationship between stress, migraine and effective therapeutic options is likely to be improved by characterizing individual patterns of stress and migraine, and may in turn improve therapeutics.

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“…Responses to the four items were summed together to create the PSS, with higher values representing more perceived stress (α= .73). Previous research has established the validity and reliability of this measure in predicting health status [ 61 , 62 ].…”

Section: Methodsmentioning

confidence: 99%

Material hardship, perceived stress, and health in early adulthood

Huang

Heflin

Validova

2021

Annals of Epidemiology

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Objective We examined the associations between material hardship and health outcomes in early adulthood, and the extent to which these associations are mediated by perceived stress. Methods We used Wave I & IV of the National Longitudinal Study of Adolescent Health (Add Health), a nationally representative survey of young adults aged 18 to 34 years old ( N =13,313). Multivariate logistic regression and decomposition methods were used to evaluate the associations between types and depth of material hardship (food, bill-paying and health resource hardship) and health outcomes (self-rated health, depression, sleep problems, and suicidal thoughts) in early adulthood, and the extent to which these associations were mediated by perceived stress. Results The adjusted odds of fair or poor health status, depression, sleep problems, and suicidal thoughts were higher among individuals with material hardship than counterparts without. A considerable proportion of the association between material hardship and health outcomes was attributable to perceived stress. Conclusions Material hardship is associated with adverse health outcomes in early adulthood, and these relationships are robust after accounting for various sociodemographic characteristics and family background. Perceived stress accounted for a sizable portion of the effects of material hardship on health. Public Health Implications Efforts to promote health equity in young adults should focus on material hardship and associated stressful conditions.

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Do Personality Traits Mediate the Relationship Between Childhood Abuse and Migraine? An Exploration of the Relationships in Young Adults Using the Add Health Dataset

Cited by 16 publications

References 73 publications

Migraine and Neuroticism: A Scoping Review

Migraine and Neuroticism: A Scoping Review

Is there a causal relationship between stress and migraine? Current evidence and implications for management

Material hardship, perceived stress, and health in early adulthood

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