Is there a causal relationship between stress and migraine? Current evidence and implications for management

Stubberud, Anker; Buse, Dawn C.; Kristoffersen, Espen Saxhaug; Linde, Mattias; Tronvik, Erling

doi:10.1186/s10194-021-01369-6

Cited by 39 publications

(34 citation statements)

References 90 publications

(91 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A study conducted by Kelman showed that stressful life events were a risk factor for the development of chronic headaches. Further, stress is also the commonest trigger for acute episodes of chronic headaches as reported by patients (Kelman, 2007;Stubberud et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…Among these, emotional strain is the most widely spread factor which trouble individuals regardless of age (Nicholson et al, 2007). According to the World Health Organization, stress is the "health epidemic of the 21 st century" and is one of the commonest triggers for migraine and tension type headaches (Stubberud et al, 2021). Similarly, young adults are mostly affected by emotional strain as they undergo busy and stressful lives more than the other age groups (Matos et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effectiveness of Acupuncture for Chronic Headache due to Perceived Stress

Hemasinghe¹,

Samaranada²,

Ranasinghe³

et al. 2022

IJKIU

View full text Add to dashboard Cite

The global prevalence of active headache disorders is estimated to be around 52%. The International Headache Society (IHS) defines chronic daily headache as, having 15 or more headache episodes per month consecutively for at least 3 months. Acupuncture is one of the most common alternative medicines used to treat chronic pain in patients. In Sri Lanka, there are no documented reports to evaluate the prevalence of headaches caused by perceived stress. Therefore, the current study aimed to assess the efficacy of acupuncture for chronic headaches caused by perceived stress in patients who visited the acupuncture clinic at KIU. Forty patients were selected using a convenient sampling method, and their stress levels were assessed using the Perceived Stress Scale (PSS). The Numeric Pain Rating Scale (NPRS) was used to assess the intensity of the headache prior to treatment. Following six weeks of acupuncture treatment, post-intervention PSS and NPRS were assessed. A strong positive correlation (r2=0.929, p=0.001) was determined between the levels of stress and the severity of headache. Furthermore, a statistically significant (p=0.001) decrease in means scores of stress and pain was found following acupuncture treatments. Therefore, it was concluded that acupuncture is an effective treatment method for chronic headache due to perceived stress.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effectiveness of Acupuncture for Chronic Headache due to Perceived Stress

Hemasinghe¹,

Samaranada²,

Ranasinghe³

et al. 2022

IJKIU

View full text Add to dashboard Cite

show abstract

“…Avona and others also demonstrated that stress induction in mice elicits migraine-like behaviors, causing a sensitization in all the studied animals ( Avona et al, 2020a ). On the other hand, it is known in the literature that stress does not induce a migraine attack in all patients, and, in non-migraineurs, stress does not produce migraine ( Stubberud et al, 2021 ). However, other animal models of headache and migraine developed in mice and rats also induced nociception in all the animals, as demonstrated by prior surveys ( Dina et al, 2011 ; Avona et al, 2020b ; Eller et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Unpredictable Sound Stress Model Causes Migraine-Like Behaviors in Mice With Sexual Dimorphism

et al. 2022

View full text Add to dashboard Cite

Migraine represents one of the major causes of disability worldwide and is more prevalent in women; it is also related to anxiety symptoms. Stress, such as sound stress, is a frequently reported trigger in migraine patients, but the underlying mechanisms are not fully understood. However, it is known that patients with migraine have higher levels of plasma inflammatory cytokines and calcitonin gene-related peptide (CGRP). Stress mediated by unpredictable sound is already used as a model of painful sensitization, but migraine-like behaviors and sexual dimorphism have not yet been evaluated. This study characterized nociception and anxiety-related symptoms after the induction of sound stress in mice. C57BL/6 mice (20–30 g) were exposed to unpredictable sound stress for 3 days, nonconsecutive days. We observed enhanced plasma corticosterone levels on day 1 after stress induction. First, 7 days after the last stress session, mice developed hind paw and periorbital mechanical allodynia, grimacing pain behavior, anxiety-like symptoms, and reduced exploratory behavior. The nociceptive and behavioral alterations detected in this model were mostly shown in female stressed mice at day 7 post-stress. In addition, on day 7 post-stress nociception, these behaviors were consistently abolished by the CGRP receptor antagonist olcegepant (BIBN4096BS, 100 mg/kg by intraperitoneal route) in female and male stressed mice. We also demonstrated an increase in interleukine-6 (IL-6), tumor necrosis factor (TNF-α), and CGRP levels in stressed mice plasma, with female mice showing higher levels compared to male mice. This stress paradigm allows further preclinical investigation of mechanisms contributing to migraine-inducing pain.

show abstract

“…Women with children may have more parenting stress than nulliparous women, which can aggravate migraine 24,25 . However, our study did not investigate the relationship between stress factors and migraine risk.…”

Section: Parity and Migrainementioning

confidence: 99%

The influence of reproductive factors on migraine in premenopausal women: A nationwide population-based study in South Korea

Kim

Lee

Hong

et al. 2022

Preprint

View full text Add to dashboard Cite

Sex hormones significantly impact the risk and pattern of migraine in women. Women experience various hormonal changes associated with pregnancy, childbirth, breastfeeding, and contraception. This study investigated the influence of reproductive factors on migraine in women. We used the linked Korean National Health Insurance Service (KNHIS) and Korean Health Examination (KHE) databases. Reproductive factors were defined as parity, breastfeeding, and oral contraceptive use. This study enrolled 1,059,579 premenopausal women. The study population was divided into two groups depending on whether the patient was newly diagnosed with migraines during the follow-up period (2009–2018). The risk of migraine tended to increase in the primiparous (HR: 1.175; 95% CI: 1.136–1.215) and multiparous groups (HR: 1.197; 95% CI: 1.161–1.235) compared to the nulliparous group. Breastfeeding (6–12 months, HR: 1.047; 95% CI: 1.029–1.066, and ≥ 12 months, HR: 1.104; 95% CI: 1.085–1.123) significantly increased migraine risk compared with not breastfeeding. All women in the oral contraceptive groups (< 1 year, HR: 1.048; 95% CI: 1.028–1.069 and ≥ 1 year, HR: 1.102; 95% CI: 1.069–1.136) showed a higher risk compared with the non-oral contraceptive group. Our study suggests that the experience of childbirth, longer breastfeeding, and oral contraceptive use may be associated with higher migraine risk in premenopausal women.

show abstract

Is there a causal relationship between stress and migraine? Current evidence and implications for management

Cited by 39 publications

References 90 publications

Effectiveness of Acupuncture for Chronic Headache due to Perceived Stress

Effectiveness of Acupuncture for Chronic Headache due to Perceived Stress

Unpredictable Sound Stress Model Causes Migraine-Like Behaviors in Mice With Sexual Dimorphism

The influence of reproductive factors on migraine in premenopausal women: A nationwide population-based study in South Korea

Contact Info

Product

Resources

About